HEALTH INFORMATICS ENTREPRENEURSHIP SHARING EXPERIENCE FROM BENCH TO BEDSIDE Eric King, CEO & Cofounder

2 0 EHR in Hospital System GRT Knowledge Discovery Cloud Service:

3 Over 20 million patient claims Over 8 million publicly available medical articles Medical reference content Standardized map of medical concepts from NIH

4 GRT (143 Similar Cases) 24 YO African American female with sickle cell anemia presents with jaundice CC: abdominal discomfort

5 GRT80% GRT30% GRT (143 Similar Cases)

6 Past Medical History Relevance Einstein ED visit 2 months ago: Cholecystitis Cholecystitis linked to Abdominal pain Past Medical History Potentially Relevant to Chief Complaint of Abdominal Pain More info EHR

7 Review the Possibilities Build the Case Explore next steps to narrow the differential

1) CARVING OUT THE UNDERLYING PROBLEM

2) IDENTIFYING HIGHEST YIELD SOLUTIONS

3) VALIDATION THROUGH BACK-TESTING True label Predicted label

4) FIELD TESTING Time 1: Past Medical History Time 2: Imaging Results Residents: Hepatitis Biliary Obstruction Hepatic Sequestrtatio n Cholestasis as complication of Sickle Cell Residents: Obstructive Jaundice

THE FUTURE OF MEDICINE IS NOW "The application of what we know already will have a bigger impact on health and disease than any drug or technology likely to be introduced in the next decade" --Dr. Muir Gray, Director of Clinical Knowledge for the UK’s National Health Service (NHS)