ACRIN Fall Meeting 2010 BDMC Report and Perspective Constantine Gatsonis, PhD ACRIN Biostatistics and Data Management Center Brown University
ACRIN Fall Meeting Developing and launching new studies: Cancer: 6681, 6685, 6686, 6687, 6688, 6689, 6690, 6691, 6692, 6693, 6694, 6695, 4006 Cardiovascular: 4005, Analyzing data for primary and secondary papers and abstracts: 6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666, 6667, 6668, 6673, 6677, 6683 AHRQ funding for RESCUE 3.Pursuing new research and funding opportunities: AHRQ funding for RESCUE BDMC : Highlights
ACRIN Fall Meeting Deciphering the link of tests to outcomes CT Angiography vs usual care ( 4005 and the RESCUE study) Pre-op MRI for breast cancer (6694, with ACOSOG ) 2.Accuracy in diagnosis and staging DCE-CT vs DCE-MRI for HCC (6690) PET/CT for H&N cancer (6685) 3.Imaging-based biomarkers for predicting response and long term outcomes. Themes of new studies
ACRIN Fall Meeting Methodologic challenges Building the outcomes enterprise: ACRIN in the CER era Dx information Outcomes CER calls for illuminating the complex path: The main pathway goes through therapy
ACRIN Fall Meeting Randomized studies address many of the methodologic difficulties but can be large, lengthy, and costly. ACRIN has unique scientific expertise, practical experience and infrastructure to pursue them Building the outcomes enterprise: ACRIN in the CER era Dx information Outcomes
ACRIN Fall Meeting Observational studies Registries (e.g. NOPR) Linkage of clinical trial data and secondary databases (CMS, EMR) Important opportunities for ACRIN Area for current GO grant (Dartmouth, Brown, NOPR, Tufts EPC), built around ACRIN’s Outcomes Committee and NOPR Building the outcomes enterprise: ACRIN in the CER era Dx information Outcomes
ACRIN Fall Meeting Modeling studies To assess the impact on outcomes using the findings from ACRIN trials ( DMIST, NLST, NCTCC, 6666) To combine information from ACRIN trials with others from the literature (CISNET ) Area for to develop, with leadership from ACRIN’s Outcomes Committee Building the outcomes enterprise: ACRIN in the CER era Dx information Outcomes
ACRIN Fall Meeting 2010 The scope of ACRIN research (if we can ensure appropriate funding !) CER era Dx information Outcomes