1. Biostatistics and Data Management Center 22 January 2016 Report from the Biostatistics and Data Management Center Constantine Gatsonis, PhD ACRIN Biostatistics and Data Management Center Brown University Providence, RI

2. Biostatistics and Data Management Center  Major emphasis on developing and launching new studies:  Cancer: 6681, 6682, 6683, 6684, 6685, 6686, 6687, 6688, 6689, 6690, 6691  Cardiovascular: 4005  Analysis for primary and secondary papers and abstracts in several protocols:  6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666, 6667, 6668, 6673, 6677, 6683 BDMC 2008-2009: Highlights

3. Biostatistics and Data Management Center  Imaging-based biomarkers for predicting response to therapy and long term outcomes.  Majority of new studies  CAD evaluation.  Accuracy in diagnosis and staging.  Diagnostic test impact on outcomes.  Significant methodologic and practical challenges Themes of new studies

4. Biostatistics and Data Management Center  Cu64-ATSM PET for cervical cancer (6682)  FMISO in glioblastoma (6684)  DCE-MRI, DSC-MRI in glioblastoma(6686)  F-Fluoride PET in prostate cancer (6687)  FLT PET in breast cancer (6688)  FLT PET and DCE-MRI in glioblastoma (6689)  Optimal imaging in breast cancer (6691) Predicting response

5. Biostatistics and Data Management Center  CAD for CT Colonography (6681)  CAD for mammography (6683)  PET/CT for head and neck cancer (6685)  CDE-MRI and DCE-CT for HCC in liver transplant candidates (6690) Accuracy: diagnosis and staging

6. Biostatistics and Data Management Center  CT angiography in the emergency room: Randomized comparison to usual care (4005).  Preoperative MRI for women with breast cancer: Randomized study of impact on surgical outcomes, recurrence, quality of life and cost. (in development) Impact on outcomes

7. Biostatistics and Data Management Center  Analysis for primary and secondary papers and abstracts in several protocols:  6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666, 6667, 6668, 6673, 6677, 6683  Solid presence at RSNA.  Abstracts at ASCO and other conferences.  Publications volume needs to increase.  Paper writing needs more attention and energy. Analysis and publications

8. Biostatistics and Data Management Center  Needs identified (from last year’s presentation ): Fully electronic data management Improved data entry capabilities Automated system for tracking data queries.  Progress update : Finally close to making decisions on choice of new system. Transition will be a significant undertaking. Informatics and Data Management

9. Biostatistics and Data Management Center It has been quite a ride!