Canadian Study of Health and Aging The Incidence and Progression of Dementia 1996 Follow-Up Study

Canadian Study of Health and Aging Annual Numbers of New Cases of Dementia Canada, All Ages: 60,150 Source: Neurology 2000; 55: 66-73

Canadian Study of Health and Aging Age-Specific Incidence of Dementia in Canada, per thousand (whole population) Women Men Source: Neurology 2000; 55: 66-73

Canadian Study of Health and Aging CSH A Rochester Turku Bordeaux New York Mannheim Rotterdam Kungsholmen Age-Specific Incidence of Dementia, per thousand (whole population) in selected studies

Canadian Study of Health and Aging Estimates of the incidence of Alzheimer’s disease from selected studies Per thousand Age All levels of Severity. Jorm’s Meta analysis CSHA Moderate + severe Jorm’s meta analysis USA estimate Eurodem Gao’s meta analysis

Canadian Study of Health and Aging The Progression of Dementia Primitive reflexes return as dementia progresses; they show a logarithmic association with declining 3MS scores (Hogan & Ebly, 1995)Primitive reflexes return as dementia progresses; they show a logarithmic association with declining 3MS scores (Hogan & Ebly, 1995) Mortality among people with probable AD is 2.5 times higher than among non-demented people (Hogan et al., 1994)Mortality among people with probable AD is 2.5 times higher than among non-demented people (Hogan et al., 1994) There are physiologic changes as dementia progresses; these are similar for AD and vascular dementia (Hogan et al., 1996)There are physiologic changes as dementia progresses; these are similar for AD and vascular dementia (Hogan et al., 1996) The rate of functional decline rises with the severity of dementia (Mitnitski et al., 1999)The rate of functional decline rises with the severity of dementia (Mitnitski et al., 1999)