2004 ISHLT J Heart Lung Transplant 2004; 23: HEART TRANSPLANTATION Overall

2004 ISHLT J Heart Lung Transplant 2004; 23: NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR

2004 ISHLT J Heart Lung Transplant 2004; 23: AVERAGE CENTER VOLUME Heart Transplants: January 1, June 30, 2003

2004 ISHLT J Heart Lung Transplant 2004; 23: DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUME Heart Transplants: January 1, June 30, 2003

2004 ISHLT J Heart Lung Transplant 2004; 23: HEART TRANSPLANTS: Donor Age by Year of Transplant

2004 ISHLT J Heart Lung Transplant 2004; 23: AGE DISTRIBUTION OF HEART RECIPIENTS (1/1982-6/2003) % of Trnsplants % of Transplants

2004 ISHLT J Heart Lung Transplant 2004; 23: AGE DISTRIBUTION OF HEART TRANSPLANT RECIPIENTS BY ERA

2004 ISHLT J Heart Lung Transplant 2004; 23: HEART TRANSPLANTATION Kaplan-Meier Survival (1/1982-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: HEART TRANSPLANTATION Adult Recipients

2004 ISHLT J Heart Lung Transplant 2004; 23: DIAGNOSIS IN ADULT HEART TRANSPLANTS

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: 1/1982-6/2002) Survival (%)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: 1/1982-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: 1/1996-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Gender (Transplants: 1/1982-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1982-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1996-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by PVR (Transplants: 1/1996-6/2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RE-TRANSPLANTS 1-Year Survival

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Recipient Height

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Center volume

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Ischemia time

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Recipient Bilirubin

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Risk Factors for 1 Year Mortality Recipient creatinine

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Factors Not Significant for 1 Year Mortality Recipient Factors: VAD, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, cardiac output, weight

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/2002) Factors Not Significant for 1 Year Mortality Donor Factors: Clinical infection, history of cancer, history of hypertension, history of diabetes, height, weight, cause of death Transplant Factors: Donor/recipient BMI ratio, donor/recipient weight ratio

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1998) Risk Factors for 5 Year Mortality (N=11,963)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1998) Risk Factors for 5 Year Mortality (N=11,963)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1998) Risk Factors for 5 Year Mortality (N=11,963)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Donor BMI

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Recipient Height

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Center volume

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Ischemia time

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Recipient creatinine

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Factors Not Significant for 5 Year Mortality Recipient Factors: VAD, in hospital, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PVR, history of malignancy, weight, gender, history of malignancy, bilirubin, PCW

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Factors Not Significant for 5 Year Mortality Donor Factors: Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes Transplant Factors: Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, ABO identical/compatible

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year (N=9,182)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Donor BMI

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Recipient creatinine

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year Recipient Factors: VAD, ventilator, in hospital, IV inotropes, balloon, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PCW, PVR, history of malignancy, height, weight, gender, diabetes, PRA, bilirubin

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1995-6/1998) Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year Donor Factors: Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes Transplant Factors: Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, HLA mismatch, center volume, ischemia time Post-transplant Factors: Dialysis, prolonged graft dysfunction, permanent pacemaker

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years (N=5,952)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor BMI

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1/1990-6/1992) Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Center volume

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Functional Status (Follow-ups: January June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Employment Status (Follow-ups: January 1996-June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Rehospitalization Post-transplant (Follow-ups: January June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January 2001 – June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Induction Immunosuppression (Follow-ups: January June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2001 through June 2003 NOTE: Different patients are analyzed in Year 1 and Year 5

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up For follow-ups between January 2001 through June 2003 NOTE: Different patients are analyzed in Year 1 and Year 5

2004 ISHLT J Heart Lung Transplant 2004; 23: PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Type of Induction (Transplants: January 1, June 30, 2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Type of Induction (Transplants: January 1, June 30, 2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Maintenance Immunosuppression (Transplants: January 1, June 30, 2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR Stratified by Maintenance Immunosuppression (Transplants: January 1, June 30, 2002)

2004 ISHLT J Heart Lung Transplant 2004; 23: POST-HEART TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: POST-HEART TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: POST-HEART TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: FREEDOM FROM CAV AND FREEDOM FROM SEVERE RENAL DYSFUNCTION* For Adult Heart Recipients (Follow-ups: January 1996-June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: FREEDOM FROM CAV Stratified by Diagnosis For Adult Heart Recipients (Follow-ups: January 1996-June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTS Cumulative Prevalence in Survivors (Follow-ups: April 1994-June 2003) Malignancy/Type1-Year Survivors 5-Year Survivors 7-Year Survivors No Malignancy15396 (96.8%)4697 (83.1%)1994 (75.9%) Malignancy (all types combined)502 (3.2%)957 (16.9%)633 (24.1%) Malignancy Type Skin Lymph Other Type Not Reported Other includes: prostate (11, 33, 25), adenocarcinoma (7, 4, 2), lung (5, 3, 2), bladder (4, 5, 5), sarcoma (3, 3, 1), breast (2, 8, 6), cervical (2, 4, 1), colon (2, 2, 3), and renal (2, 7, 3). Numbers in parentheses are those reported within 1 year, 5 years and 7 years, respectively.

2004 ISHLT J Heart Lung Transplant 2004; 23: FREEDOM FROM MALIGNANCY For Adult Heart Recipients (Follow-ups: April June 2003)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years (N=5,787)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Recipient BMI

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Center Volume

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1996-6/2000) Risk Factors for Developing CAV within 3 Years Recipient Diastolic PA Pressure

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1996) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year (N=1,414)

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1996) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw Wald Label Chi-Square DF Pr > ChiSq ischtime bilirubin volume recipage donage <.0001 creatinine <.0001 rec_hgt <.0001 bmi_don pcw

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1996) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Recipient Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANTS (1995-6/1997) Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year Donor Age

2004 ISHLT J Heart Lung Transplant 2004; 23: ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January June 2003) CAUSE OF DEATH0-30 Days (N = 2,759 ) 31 Days - 1 Year (N = 2,310 ) >1 Year - 3 Years (N = 1,737 ) >3 Years - 5 Years (N = 1,492 ) >5 Years (N = 4,009 ) CAV 43 (1.6%)111 (4.8%)257 (14.8%)268 (18.0%)651 (16.2%) ACUTE REJECTION 188 (6.8%)288 (12.5%)165 (9.5%)63 (4.2%)43 (1.1%) LYMPHOMA 2 (0.1%)46 (2.0%)77 (4.4%)80 (5.4%)201 (5.0%) MALIGNANCY, OTHER 2 (0.1%)49 (2.1%)181 (10.4%)281 (18.8%)763 (19.0%) CMV 4 (0.1%)29 (1.3%)15 (0.9%)3 (0.2%)4 (0.1%) INFECTION, NON-CMV 370 (13.4%)784 (33.9%)234 (13.5%)145 (9.7%)393 (9.8%) PRIMARY FAILURE 747 (27.1%)186 (8.1%)119 (6.9%)68 (4.6%)200 (5.0%) GRAFT FAILURE 400 (14.5%)245 (10.6%)298 (17.2%)218 (14.6%)567 (14.1%) TECHNICAL 208 (7.5%)28 (1.2%)15 (0.9%)17 (1.1%)43 (1.1%) OTHER 101 (3.7%)122 (5.3%)123 (7.1%)104 (7.0%)240 (6.0%) MULTIPLE ORGAN FAILURE 382 (13.8%)228 (9.9%)86 (5.0%)83 (5.6%)335 (8.4%) RENAL FAILURE 17 (0.6%)19 (0.8%)31 (1.8%)51 (3.4%)238 (5.9%) PULMONARY 116 (4.2%)77 (3.3%)77 (4.4%)60 (4.0%)163 (4.1%) CEREBROVASCULAR 179 (6.5%)98 (4.2%)59 (3.4%)51 (3.4%)168 (4.2%)