Clinical Case 22yo G2P0010 at 11 weeks 4 days based on LMP 12/15/08 presented for initial prenatal visit 3/6/09. The patient had no complaints. Appeared.

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Presentation transcript:

Clinical Case 22yo G2P0010 at 11 weeks 4 days based on LMP 12/15/08 presented for initial prenatal visit 3/6/09. The patient had no complaints. Appeared happy about her current condition and although this pregnancy was “unplanned” the patient reported that her and her boyfriend (FOB) were actively having sex without contraception. The patient stated that her mom and boyfriend were very concerned about this pregnancy. And during the interview FOB called 2x. Denied contractions, vaginal bleeding, vomiting. + nausea induced by hypersensitivity to strong smells. POBhx -prior 2nd trimester loss 7/07 at 24 weeks. Pt indicated she was told she has a “low uterus” PGYNhx -menarche:? Menstruation: regular, Q28days -no h/o uterine fibroids, ovarian cysts -history of STIs—chlamydia /trichomonas coinfection discovered by screening Oct ‘04and pt was treated at that time. PMhx -asthma, mild interrmittent, 1 ett in 2006 -lactose intolerance

PShx none Meds Albuterol prn PNV Allergies: NKDA Mustard—hives, SOB Social Hx: -Denied tobb, ETOH, Drug use. Separated from husband of 2 yrs. Currently unemployed and living with boyfriend of 1+yrs that works full time as self employed contractor. Family Hx: noncontributory PNL: A+ ab-/HBsag-/syphilis NR/rubella immune/GC-/chlamy- PE: Vitals: Wt 199 (prepreg 180) BP100/60 Abd/Pelvic exam: Gravid uterus palpated above pubic symphisis FHT present Vagina—no lesions, normal musosa Cervix—no CMT, cervical length not assessed.

A/P -Pt already scheduled for ultrasound dating 3/19/09 -Referral to High Risk clinic at CFCC based on history -Regular screening test ordered (GCT) -WIC form completed

Management of Cervical Insufficiency F. Akanki March 2009

Normal Cervix Anatomical Components: -histologically contains Fibrocollagenousstromal tissue -Endocervix -Ectocervix- portion projecting into the vagina. On average, its 3 cm long and 2.5 cm wide, has a convex, elliptical surface and is divided into anterior and posterior lips. -Internal os -External os – its size and shape varies widely with age, hormonal state, and whether the woman has had a vaginal birth. In nonparous women it appears as a small, circular opening. Versus being fish mouthed--meaning wider, more slit-like and gaping in parous women. In pregnancy the normal cervical length measured from internal to external os is 4 +/- 1cm. Up through 3rd trimester cervix should remain L/C/B.

Definition of cervical insufficiency (aka cervical incompetence) A condition in pregnancy where the cervix begins to dilate (and not by initiation of contractions but) due to structural weakness in the cervix itself there is an inability to hold the weight of the pregnancy -- resulting in bulging of the amniotic membranes into the vaginal canalrupturepreterm labor/fetal loss. (Usually occuring in the 2nd trimester)

Risk Factors -Recurrent 2nd trimester losses -History of incompetent cervix with a previous pregnancy -Cervical injury -multiple D&C -Repeated surgical trauma - repeated pregnancy termination, -cone biopsy - cervical cautery (to remove growths or stop bleeding) -Anatomic abnormalities of the cervix -congenital cervical hypoplasia or aplasia -DES (diethylstilbestrol) exposure -Connective tissue disorders (Ehlers-Danlos syndrome)

Incidence -Cervical incompetence affects 1 % of the obstetric population. -15-20 percent of miscarriages that occur between 16 and 24 weeks of pregnancy are believed to stem from this etiology

Diagnosis based on an obstetric history of recurrent second- or early third-trimester fetal loss with the above criteria mentioned (painless cervical dilation). However in the absence of recurrence the term cervical insufficiency is used as a working diagnosis based on a single event with the same clinical history, after exclusion of other causes of preterm delivery. Without a prior history of fetal loss, using this term in connection with a short or traumatized cervix alone is not sufficient. Digital exam is very subjective. And diagnosis by transvaginal ultrasonography is more of a repoducible method of measuring the cervix.

Transvaginal ultrasound -Clinically useful to identify signs of effacement (funnelling) and cervical length. -Assessment of the cervix can be done at rest and with application of transfundal/abdominal pressure. TFP is more effective than standing in eliciting cervical changes.

-Funnelling specifically refers to the separation of the internal os from the two sidewalls of the upper end of the cervical canal. - A normal sagittal view of the cervix shows a “T” shaped endocervical canal vs. deviations such as Y, V, U. Y= initial effacement and subsequent V, U visualized on progressive endocervial change and cervical shortening.

Sonographic findings -funneling (mneumonic: Trust Your Vaginal Ultrasound ) -cervical length <25mm -protrusion of membranes -presence of fetal parts in cervix or vagina

Symptoms -If a patient presents with significant cervical dilation (2 cm or more) she may have minimal symptoms. (ie. Pelvic pressure, minimal contractions) -When the cervix reaches 4 cm or more, active uterine contractions or rupture of membranes may occur

Management

ACOG recommendations based on limited or inconsistent scientific evidence (Level B): -Serial TVS assessments in low-risk women to screen for CI are of low yield and should not be done routinely. Management should be determined by prior history. -Serial ultrasound exams every 2 weeks should be considered in a patient with historical risk factors and should be initiated between 16 and 20 weeks of gestation or later. If initiated earlier and the patient appears to have a short cervix then the exam needs to be repeated because usually the upper portion of the cervix is not easily distinquished from the lower uterine segment. -An elective cerclage can be considered in a patient with a history of 3 or more unexplained midtrimester pregnancy losses or preterm deliveries. -Women exposed to diethylstilbestrol (DES) in utero may be evaluated for cervical insufficiency using the same clinical criteria as nonexposed individuals

ACOG recommendations… Based on level C evidence (primarily consensus and expert opinion) -The evaluation of a patient with cervical shortening or funneling should include a comprehensive ultrasonographic assessment of the fetus to rule out anomalies, tocometry and lab assessments to rule out labor and chorioamnionitis. –short cervix considered <25mm ( <10th percentile). So if labortocolytics, steroids for fetal lung maturity infection delivery, abx or conservative management limit activity, expectant management -Given the advances in neonatal care and the potential maternal and fetal morbidity associated with cerclage, surgical correction of cervical insufficiency should be limited to pregnancies before fetal viability has been achieved.

Treatments -Bed rest and reduced physical activity--common practice but not medically proven to be effective -Pelvic rest -limit sexual intercourse -cerclage-surgical purse string type suture used to reinforce cervix.

Cerclage Indications for elective cerclage: -congenital or acquired visible defects in the ectocervix classic features of cervical incompetencehistory of 2 or more 2nd trimester losses (excluding those resulting from preterm labor or abruption) history of losing each pregnancy at an earlier gestational age history of painless cervical dilation of up to 4 to 6 cm history of cervical trauma caused by cone biopsy, intrapartum cervical lacerations excessive, forced cervical dilation during pregnancy termination.

Cerclage -indicated for placement at 13-16 weeks GA after fetal viability established on ultrasound -urgent/therapeutic cerclage indicated for patients that have serial ultrasound changes consistent with short cervix or funneling. Management of this group remains speculative because of the limited number of well-designed randomized trials. The decision to proceed with cerclage should be made with caution.

Macdonald cerclage procedure (1963) -Running suture placed in the body of the cervix near the internal os to encircle the cervix . Its tightened to reduce the cervical canal to 5-10mm

Modified Shirodkar procedure (1955) -More complicated and involving an anterior incision, placement and tying of special Mersiline tape with suturing of the cervical mucosa back in place. -reserved for patients that have had failure with the Macdonald procedure .

Contraindications/complications/when to remove Contraindications: bleeding, ruptured membranes, uterine contractions Complications: Suture disruption, rupture of membranes, and chorioamnionitis are the most common assoc with cerclage placement. The correct time for removal is unclear based on the small, nonrandomized studies available but removal should be an appropriate time before labor. Circa 37 weeks.

Management strategy based on risk factors

Sources -Drakeley et al. Midtrimester loss—appraisal of a screening protocol. 2003 Human Reproduction, Vol 13, 1975-1980 Ultrasound in gynecology. By Ilan E. Timor-Tritsch, Steven R. Goldstein Published by Elsevier Health Sciences, 2007 - Ressel . Practice Guidelines: ACOG Releases Bulletin on Managing Cervical Insufficiency. American Family Physician. January 15, 2004 issue ACOG. cervical insufficiency. 2003 nov 9. Acog practice bulletin; no 48 Ahn et al. The short cervix in pregnancy:Which therapy reduces preterm birth?. OBG management. August 2003.p 28-38 Guzman  ER, Forster  JK, Vintzileos  AM , et al.  Pregnancy outcomes in women treated with elective versus ultrasound-indicated cervical cerclage.  Ultrasound Obstet Gynecol.  1998; 12: 323 –327. -Williams Obstetrics: 22nd edition. F. Gary Cunningham, Kenneth L. Leveno, Steven L. Bloom, John C. Hauth, Larry C. Gilstrap III, Katharine D. Wenstrom. Chapt 9: abortion.2005, 2001 by the McGraw-Hill Companies, Inc