Core Laboratory of Population Genetic Polymorphisms 族群遺傳核心實驗室負責人：陳為堅于明暉 National Taiwan University Center for Genomic Medicine 台大基因體醫學中心.

Slides:

Advertisements

Similar presentations

Regulation of Consumer Tests in California AAAS Meeting June 1-2, 2009 Beatrice OKeefe Acting Chief, Laboratory Field Services California Department of.

Advertisements

Lecture 2 Strachan and Read Chapter 13

Applications of HGP Genetic testing Forensics. Testing for a pathogenic mutation in a certain gene in an individual that indicate a persons risk of developing.

ISI Foundation G. Matullo, P. Vineis M. Manuguerra, F. Saletta DNA repair genes and cancer Web registry on DNA repair polymorphisms and cancer risk website.

MEMS Thermal & Fluid Control Lab. 國立台灣大學機械工程系微機械熱流控制實驗室 Department of Mechanical Engineering National Taiwan University, Taipei, Taiwan Department of Mechanical.

Which Phenotypes Can be Predicted from a Genome Wide Scan of Single Nucleotide Polymorphisms (SNPs): Ethnicity vs. Breast Cancer Mohsen Hajiloo, Russell.

Genetic research designs in the real world Vishwajit L Nimgaonkar MD, PhD University of Pittsburgh

SNP Applications statwww.epfl.ch/davison/teaching/Microarrays/snp.ppt.

The Veterans Affairs Central Biorepository and MVP Highlights Mary T

Standardization within the consortium Cancer consortia Paolo Boffetta IARC.

Dr. Almut Nebel Dept. of Human Genetics University of the Witwatersrand Johannesburg South Africa Significance of SNPs for human disease.

The Pursuit of Better Medicines through Genetic Research Terri Arledge, DVM US Department Head Drug Development Genetics.

Mini-Talk 2a The Sister Study Genetics, the environment, their interaction and breast cancer risk How will biomonitoring be used in this long-term study.

Positional Cloning LOD Sib pairs Chromosome Region Association Study Genetics Genomics Physical Mapping/ Sequencing Candidate Gene Selection/ Polymorphism.

Human Genetics Overview.

資訊教育吳桂光東海大學物理系助理教授 Tel: 3467 Office: ST223 Office hour: Tue, Fri. (10-11am)

Seminar Assignment HT Seminar assignment Handed out at course start Group work / individual assessment Research based aspects, requires independent.

Introduction to Molecular Epidemiology Jan Dorman, PhD University of Pittsburgh School of Nursing

Paola CASTAGNOLI Maria FOTI Microarrays. Applicazioni nella genomica funzionale e nel genotyping DIPARTIMENTO DI BIOTECNOLOGIE E BIOSCIENZE.

Y. Chaiter 1, Y. Machluf 1, A. Pirogovsky 2, A. Yona 1, A. Navon 1, O. Tal 2, E. Ringler 1, G. Abbebe-Campino 1, Y. Erlich 1, and N. Ash 2 1 Israel Defence.

Selecting TagSNPs in Candidate Genes for Genetic Association Studies Shehnaz K. Hussain, PhD, ScM Assistant Professor Department of Epidemiology, UCLA.

WTCRF Nursing & Clinical Epidemiology & Statistics Image Analysis

Understanding Genetics of Schizophrenia

Host Genomics in WIHS  The WIHS GWAS data set  Concept Sheet  Data use agreement  Data transfer  Analytic support.

Georgia Wiesner, MD CREC June 20, GATACAATGCATCATATG TATCAGATGCAATATATC ATTGTATCATGTATCATG TATCATGTATCATGTATC ATGTATCATGTCTCCAGA TGCTATGGATCTTATGTA.

Standardization of Pedigree Collection. Genetics of Alzheimer’s Disease Alzheimer’s Disease Gene 1 Gene 2 Environmental Factor 1 Environmental Factor.

Strong Heart Family Study Phase VI Genetics Center Aims October 8, 2009.

Searching Microsatellite Markers for Mapping a Disease Gene

Epigenome 1. 2 Background: GWAS Genome-Wide Association Studies 3.

Single Nucleotide Polymorphism

Utilizing Science & Technology and Innovation for Development A Genome Wide Association Study for Type 2 Diabetes Susceptibility Gene and Treatment in.

Introduction of Department of Molecular Biology for Public Health in SCDC Ye Lu Shanghai Municipal Center for Disease Control & Prevention Shanghai Institute.

The Complexities of Data Analysis in Human Genetics Marylyn DeRiggi Ritchie, Ph.D. Center for Human Genetics Research Vanderbilt University Nashville,

POLICY DILEMMAS IN GENOMICS AND INTERNATIONAL HEALTH POLICY Elettra Ronchi, PhD

The medical relevance of genome variability Gabor T. Marth, D.Sc. Department of Biology, Boston College Medical Genomics Course – Debrecen,

©Edited by Mingrui Zhang, CS Department, Winona State University, 2008 Identifying Lung Cancer Risks.

動物模式核心實驗室 Tumorgenesis nude mice model Disease animal model Gene therapy model Drug delivery animal model 研究技術 / 方法.

AUA/OSI Workshop Functional based competencies ASSESSMENT Facilitator: Crape Byron Janev Holcer NatasaShabashov Alexey Sumskas LinasGill Artyom Isjanovska.

Genetic Repositories Australia BACKGROUND GRA supported by an NHMRC Enabling Facility Grant awarded in  GRA supported by an NHMRC Enabling Facility.

Polysubstance Abuse–Vulnerability Genes: Genome Scans for Association, Using 1,004 Subjects and 1,494 Single-Nucleotide Polymorphisms Uhl, Liu, Walther,

11/19/2015 Utah High-Risk Asthma Pedigree Study Lisa Cannon-Albright, PhD Department of Biomedical Informatics University of Utah School of Medicine In.

GGAW - Oct, 2001 M-W LIN Searching Microsatellite Markers for Mapping a Disease Gene 林明薇 Ming-Wei Lin, PhD 陽明大學醫學系家庭醫學科台北榮民總醫院教學研究部.

Bioinformatics and Computational Biology

Gene Mapping ROBERT SANTOS ENGLISH 100 ESP NOVEMBER

The International Consortium. The International HapMap Project.

Kathleen Giacomini, Mark J. Ratain, Michiaki Kubo, Naoyuki Kamatani, and Yusuke Nakamura NIH Pharmacogenomics Research Network III & RIKEN Center for Genomic.

Clinical Research and Outcomes Registry Workshop Creating an Informed Consent Form Daniel Ford, MD, MPH Joseph Carrese, MD.

BIOSTATISTICS Lecture 2. The role of Biostatisticians Biostatisticians play essential roles in designing studies, analyzing data and creating methods.

Regulatory Guidance for Genetic Testing. Three Specific Areas Laboratory tests Results of genetic testing – Clinical – Research GenomeWide Association.

The analysis of A Genome-wide Association Study of Autism Reveals a Common Novel Risk Locus at 5p14.1 Rodney Knowlton Kyle Andrews.

Population Data Research Core Holden Comprehensive Cancer Center University of Iowa.

Jan 2002 EDMA The central role of the Medical Laboratory in a World of Managed Health An EDMA presentation of the benefits of in vitro testing as a basis.

Statistical Analysis of Candidate Gene Association Studies (Categorical Traits) of Biallelic Single Nucleotide Polymorphisms Maani Beigy MD-MPH Student.

Different microarray applications Rita Holdhus Introduction to microarrays September 2010 microarray.no Aim of lecture: To get some basic knowledge about.

1 Finding disease genes: A challenge for Medicine, Mathematics and Computer Science Andrew Collins, Professor of Genetic Epidemiology and Bioinformatics.

LCA1 Erman Ayday, Jean Louis Raisaro and Jean-Pierre Hubaux Privacy-Enhancing Technologies for Medical Tests and Personalized Medicine Laboratory for Computer.

Development of an interactive pipeline for Genome wide association analysis Falola Damilare & Adigun Taiwo – Covenant University Bioinformatics research.

Genetic Testing for the Clinician

Introduction to Direct-to-Consumer Genetic Testing

Introduction to bioinformatics lecture 11 SNP by Ms.Shumaila Azam

Content and Labeling of Tests Marketed as Clinical “Whole-Exome Sequencing” Perspectives from a cancer genetics clinician and clinical lab director Allen.

High level GWAS analysis

Epidemiology 101 Epidemiology is the study of the distribution and determinants of health-related states in populations Study design is a key component.

Direct-To-Consumer Genetic Testing

Power to detect QTL Association

Africa Center of Excellence on Neglected Tropical Diseases and Forensic Biotechnology (ACENTDFB) Ahmadu Bello University, Zaria http.//

Pierre Nahon, Jessica Zucman-Rossi Journal of Hepatology

One SNP at a Time: Moving beyond GWAS in Psoriasis

Discovery From Data Repositories H Craig Mak Nature Biotechnology 29, 46–47 (2011) 2013 /06 /10.

Hunting for Celiac Disease Genes

Presentation transcript:

Core Laboratory of Population Genetic Polymorphisms 族群遺傳核心實驗室負責人：陳為堅于明暉 National Taiwan University Center for Genomic Medicine 台大基因體醫學中心

Rationale Population-based epidemiological studies to unravel the genetics of complex diseases Linkage analysis vs. association study Research strategies Either candidate gene approach or genomewide screen Either candidate gene approach or genomewide screen Single nucleotide polymorphism (SNP) Single nucleotide polymorphism (SNP) L arge-scale population-based association studies L arge-scale population-based association studies

Overall Goal To establish a system for recruiting a large number of individuals with DNA and phenotypic data that will be useful for future genetic dissection of complex diseases

Specific Aims 200,000 blood samples and questionnaire data collection DNA bank establishment Specific genetic variants identification Examination of association between various diseases and specific genetic markers

Methodology Subjects recruitment Biospecimen bank Data collection and management Follow-up Data linkage with National Health Insurance Database Data linkage with National Health Insurance Database

Lab Facility Controlled Rate Freezing System and Liquid Nitrogen Storage System ( 微電腦控制自動充填液態氮保存系統 ) Forma Scientific, Bioway 7460 Forma Scientific, Bioway ˚C Freezer Database National Mortality Database National Mortality Database Cancer Registry Database Cancer Registry Database National Health Insurance Database National Health Insurance Database

Interaction with Other Labs Interaction with Laboratory of Bioinformatics Handling of massive data and Extraction of information from the large-scale population database Handling of massive data and Extraction of information from the large-scale population database Interaction with Laboratory of Microarray and Gene Chip DNA subjected to genotyping DNA subjected to genotyping Interaction with Other Laboratory Relevant analyses of genes Relevant analyses of genes

Lab Services Long-term storage and computerized management of DNA In liquid nitrogen tank In liquid nitrogen tank DNA extraction training for research assistants Good quality that lasts long Good quality that lasts long Linkage between large-scale database systems Mortality Database, Cancer Registry Database, National Health Insurance Database Mortality Database, Cancer Registry Database, National Health Insurance Database

Significance of Lab Quantifying the impact of various genetic variants on the risk of disease in terms of attributable risks in different ethnic groups Assessing the validity of new genetic tests in different ethnic groups Evaluating the impact of genetic tests on morbidity, mortality and cost in different ethnic groups