CHANGING WORLDS The Impact of University Research

Microwaves In Medical Therapy Dr. Peter Clegg Prof. Nigel Cronin University of Bath, UK

Introduction to UOB/Microsulis/Acculis Microwave Therapies 1994 Endometrial Ablation – treatment of menorrhagia avoiding hysterectomy Soft Tissue Ablation - the destruction of unwanted tissue, mainly tumours at surgery Start development of smaller diameter devices for percutaneous use in an interventional radiological setting CE mark and FDA 501(k) approval for surgical tissue ablation CE mark and FDA 510(k) approval for interventional radiology soft tissue ablation.

Microwave Endometrial Ablation (MEA) Minimally invasive transcervical procedure that does not require hysteroscopic equipment Closed microwave system incorporating a hand-held microwave applicator that ablates only a thin layer of tissue inside the uterus without heating adjacent organs MEA Applicator

Microwave Tumour Ablation Microwave antenna placed directly into tumour at surgery. Antenna energised to ablate tissue with ultrasound / temperature monitoring. Technique involves optimisation of energy deposition from the radiated field.

MTA Surgical / Laparoscopic Applicators 5.6 mm interstitial applicator FE simulation 5mm applicator SAR5mm applicator ex vivo lesion

MTA Open Surgical Surface Thermal Lesions 20mm applicator SAR 20mm interface applicator FE simulation Applicator in use Lesion cross section

MW Heating Mechanism  Effective and consistent heating in all soft tissue organs.  Faster, bigger, more repeatable ablations than RF. O + E field H H O + H H - + Heating mechanism: coupling to water dipole.

MTA/pMTA Applicator Comparison

Clinical Effect of pMTA CT image – tumour pre-opCT image – ablation post-op

MEA/MTA/pMTA Clinical Usage

Future Research and Development High frequency pMTA – small, precise, spherical ablations in very short times. Target lung, kidney, bone and prostate cancer. NHS HTD grant award to develop bone cancer pain palliation system. Biliary tree tumour ablation using flexible applicators. Varicose vein treatments using long flexible microwave applicators. 12 of 11

Dr. Peter Clegg University of Bath

CHANGING WORLDS The Impact of University Research