Table 4.1.1: Stock and Flow of Liver Transplantation, Year * ** New transplant patients Deaths Re-transplant Lost to follow up Functioning graft at 31 st December * 1 patient who was alive until 05/12/1997 is recorded died with missing date of death ** 1 patient who had transplanted in 2003 is recorded as death with missing date of death

Figure 4.1.1: Stock and Flow of Liver Transplantation, Number of patients (n) Year New patients Alive at 31st Dec

Table 4.1.2: Distribution of Patients by Place of Transplant, Year TOTAL No. NoNo. Local Overseas TOTAL

Table 4.1.3: Distribution of Patients by Centres for Liver Transplantation, Year TOTAL CentreNo. Subang Jaya Medical Centre Hospital Selayang Australia National University Hospital, Singapore Kings College Hospital, UK Tianjin, China Asian Centre for Liver Disease & Transplantation, Singapore * 4 TOTAL * Data was not reported

Table 4.1.4: Distribution of Transplant Recipients by Follow-up Centres, 2006 CentreNo.% Number of patient with functioning graft at 31 st December Kuala Lumpur Hospital24 SJMC27*54 Selayang Hospital1734 Singapore1*2 UMMC36 *Follow-up data was not reported

Table 4.2.1: Distribution of Patients by Gender, Year TOTAL GenderNo. Male Female TOTAL

Figure 4.2.1: Distribution of Patients by Gender, Number of patients (n) Year Male Female

Table 4.2.2: Distribution of Patients by Ethnic Group, Year TOTAL Ethnic groupNo. Malay Chinese Indian Others TOTAL

Figure 4.2.2: Distribution of Patients by Ethnic Group, Number of patients (n) Year Malay Chinese Indian Others

Table 4.2.3: Distribution of Patients by Age, Year TOTAL Age, yearsNo. < >= TOTAL Mean SD Median Minimum months1114 months11123 months Maximum * Age=date of transplant – date of birth

Table 4.2.4: Primary Diagnosis, (N=88) Year TOTAL Primary DiagnosisNo. Biliary atresia Metabolic liver disease Cholestatic liver disease Primary biliary cirrhosis Primary sclerosing cholangitis Autoimmune hepatitis Chronic hepatitis B Chronic hepatitis C Alcoholic liver disease Malignancies Acute liver failure Idiopathic / Cryptogenic Others *6 patients have more than one primary disease

Table 4.2.5: Indication for Transplantation, (N=88) Year TOTAL Indication for TransplantationNo. Recurrent encephalopathy Uncontrolled bleeding varices Intractable ascites Spontaneous bacterial peritonitis Poor liver function Malignancy Unacceptable quality of life Failure to thrive, growth retardation in paediatric patients Others No data *21 patients had 1 indication for transplantation, 63 had more than 1 indication for transplantation

Table 4.2.6: Recipient Blood Group, (N=88) Year TOTAL Blood groupNo. A B AB O No data TOTAL

Table 4.3.1: Distribution of Patients by Type of Donors, (N=88) Year TOTAL Type of TransplantNo. Cadaveric Living related - Mother Living related - Father Living related - Son Living related - Brother Living related - emotionally Living unrelated TOTAL * 1 patient is Living related - Other

Table 4.3.2: Immunosuppressive Drug Treatment at Transplantation, (N=88) Year TOTAL Immunosuppressive drugsNo. Steroids Azathioprine Cyclosporin A Tacrolimus (FK506) Mycophenolate Mofetil (MMF) Rapamycin Monoclonal / Polyclonal antibody Anti IL2R Antibodies Others No data TOTAL patients * 21 patients had 1 type of drug, 37 patients had 2 types, 17 patients had 3 types

Table 4.4.1: Patient Survival by Year of Transplant, (N=88) Year of Transplant Interval (months)% SurvivalSE% SurvivalSE SE=standard error

Figure 4.4.1: Patient Survival by Year of Transplant,

Table 4.4.2: Patient Survival by Gender, (N=88) GenderMaleFemale Interval (months)% SurvivalSE% SurvivalSE SE=standard error

Figure 4.4.2: Patient Survival by Gender,

Table 4.4.3: Patient Survival by Age Group, (N=88) Age group0-9 years>=10 years Interval (months)% SurvivalSE% SurvivalSE SE=standard error

Figure 4.4.3: Patient Survival by Age Group,

Table 4.4.4: Distribution of Patient by Cause of Death, (N=88) Year TOTAL Causes of deathNo. Graft failure Chronic graft rejection Intra-abdominal Bleeding Peritonitis CMV Pneumonia Decompensated liver cirrhosis Intracranial haemorrhage Malignancy Variceal bleed Pneumonia and respiratory failure Post transplant lymphoproliferative disease Sepsis Unknown TOTAL Note: 2 patients with no date of death