© & Confidential to The Centre for Process Innovation Ltd The Centre for Process Innovation Wilton, Redcar

© & Confidential to The Centre for Process Innovation Ltd The Strategy for Success

© & Confidential to The Centre for Process Innovation Ltd Features of the CPI vision A National Resource –World-class, internationally recognised –Regional and UK Plc agenda –Scope - base, speciality, fine, pharmaceuticals, downstream Collaborative applied research and development –Market/Industry led –Incremental build of skills, knowledge, facilities and capability –Multi-company or one-on-one Manufacturers Catalyst producers Technology developers/suppliers –Universities: regional, national and international

© & Confidential to The Centre for Process Innovation Ltd So ….. We’re here to reduce the barriers to innovation by –sharing risk, providing facilities, resources, and knowledge We’re a company limited by guarantee –we can’t make and distribute a profit We do not provide money…… –We’re not a government grant agency We’re about action…we’re here to do things –With confidentiality assured We want a (small) share of the action –To cover costs and make us self-sustaining We recruit the Best Talent available –Work as a Team

© & Confidential to The Centre for Process Innovation Ltd Strong Industry Involvement

© & Confidential to The Centre for Process Innovation Ltd How CPI works Industry/Market Demand Functional Materials Advanced Processing & Manufacturing Thrusts Platforms Programmes Science Base Universities Supercritical Fluids Company nCompany Electronic Polymers Collaborators Demand Technology Advisory Committee – oversees agenda and advises on relevance and quality Academic links will be stimulated by part-sponsorship of chairs/post-docs/joint programmes

© & Confidential to The Centre for Process Innovation Ltd Fuel Cell Applications Facility Objective: create a fuel cells cluster in the Tees Valley Static applications –Supply security and fuel efficiency main drivers –Demonstrator projects Significant Involvement –DuPont, Huntsman, Johnson Matthey*, BOC, Air Products*, Terra Nitrogen, Norsk Hydro, Black & Decker –Intelligent Energy*, Fuel Cells UK*, DTI, Carbon Trust, Canadian Research Council, US Department of Energy Progress is substantial –3 demonstrators in place, 2 more planned –Targeting €2.8bn European funding ………enabling a supply chain

© & Confidential to The Centre for Process Innovation Ltd Polymer Electronics Collaboration with DuPont Teijin Films –Initial project on the Functional Materials Platform –Objective is to develop luminescent polyester films for displays –“Disruptive Technology” –Development facility at CPI Progress –£xm project –DTF/CPI contract executed Potential consortium members –Xaar, Avecia, ICI, DuPont Teijin, Du Pont Displays, Kodak, Plastic Logic, Cambridge Displays, Philips, University of Durham –UK Plastic Electronics Manufacturing Facility potential ………Building a new industry

© & Confidential to The Centre for Process Innovation Ltd Functional Materials Platform Focused on developing new products –Significant number of opportunities –Challenge is not to get distracted! –Many companies interest in molecular level effects but common agenda needs to be defined Advanced Functional Materials Centre Proposal –£xM application to DTI –£x+M matched by Industry –Links with University of Durham, White Rose Nano-factory and others ………Exploiting material properties

© & Confidential to The Centre for Process Innovation Ltd Business Development Offers leading edge support and Technology Transfer to industry –Facilitating improvement by sharing Best Practice –Pilot plant equipment brokerage –Specialist consultancy services –Direct support to 40+ SMEs Relationships with Universities –Possible sponsorship of chairs Newcastle for Chemical Engineering Durham for Chemistry –Encouraging collaborations between Universities –Interdisciplinary Research Centre in Polymer Science –Support to spin-outs and start-ups ………leveraging knowledge

© & Confidential to The Centre for Process Innovation Ltd Bio-Processing Centre of Excellence in Bio-catalysis, Bio- transformations and Bio-catalytic Manufacturing – CoEBio3 –Focused on high value fine chemicals and pharmaceutical intermediates –Pro-Bio, EPSRC and DTI supported initiative –led by Prof Roberts from University of Manchester –£20m project over 5 years –Core academic research at Manchester plus York & Heriot-Watt –£2.5m capital pre-manufacturing scale up facility at CPI 20 + companies interested including: –AstraZeneca, GSK, Johnson Matthey, Angel Biotech, BASF –15 already signed up as of 01/12/04 ………developing new ways to make things

© & Confidential to The Centre for Process Innovation Ltd Supercritical Fluids Processing A new processing route –Enables highly selective chemistry –Of interest to control particulate formulation –Novel process fluid e.g. water –Can be used to make a wide range of molecules Developing collaborative project with several companies, Nottingham University, Newcastle University and others –Pre-competitive generic development – creating IPR for the partners –Initial programme focusing on water –£xm project –Future one-to-one programmes with other collaborators – catalysis, hydrogenation ………developing new ways to make things

© & Confidential to The Centre for Process Innovation Ltd Batch to Continuous Processing Significant opportunity: –Cost pressures as margins squeezed –Process & Analytical Technology (PAT) Initiative brings whole pharmaceutical industry into play 4 consortia running or being established : –5 companies working together with a university based technology for novel reaction systems –Several companies coming together with CPI to look at heat- exchange reaction systems –Bioreactor consortium is under development –A consortium is under development to look continuous precipitation and crystallisation options ………developing new ways to make things

© & Confidential to The Centre for Process Innovation Ltd Advanced Processing Platform Focused on manufacturing routes –More with less – increase capital intensity and variable cost efficiency –Increasing speed of development of new processes –Only making the molecules you want & reducing by-products –“Green” processing Vision is to systematically create a multi-purpose demonstration capability: –80:20 concept – non-optimised, proof of concept –Multiple feedstock and types –Reaction system options coupled with separation & purification

© & Confidential to The Centre for Process Innovation Ltd Business Intensification by Advanced Processing Feed React Separation+ Product Handling Water SCF Solvent

© & Confidential to The Centre for Process Innovation Ltd Enzyme Frisky Slow, well mixed Generic e.g.Fermentor e.g. Heat exchanger reactor e.g OBR CSTR Business Intensification by Advanced Processing

© & Confidential to The Centre for Process Innovation Ltd D A---->B---->C---->D A B B2C Business Intensification by Advanced Processing

© & Confidential to The Centre for Process Innovation Ltd Speeding the adoption of new technologies Develop and demonstrate putative processes Produce trial quantities of product Demonstrate whole process Assess and mitigate commercial case and risk

© & Confidential to The Centre for Process Innovation Ltd Thank You