Histological and Molecular Evidence of Synovial Sarcoma of Bone. A Case Report* by HIROAKI HIRAGA, TAKAYUKI NOJIMA, KAZUO ISU, KATSUSHIGE YAMASHIRO, SHINYA.

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Presentation transcript:

Histological and Molecular Evidence of Synovial Sarcoma of Bone. A Case Report* by HIROAKI HIRAGA, TAKAYUKI NOJIMA, KAZUO ISU, KATSUSHIGE YAMASHIRO, SHINYA YAMAWAKI, and KAZUO NAGASHIMA J Bone Joint Surg Am Volume 81(4): April 1, 1999 ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1 Roentgenogram of the right radius, showing a lytic lesion (arrowheads) that extends from the end of the bone with a wide zone of transition, which is indicative of an invasive tumor. HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 2 T1-weighted magnetic resonance image (repetition time, 604 milliseconds; echo time, thirty-three milliseconds). HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Figs. 3-A through 3-D: The pathological features of the tumor. HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-B Photomicrograph of the biopsy specimen. HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-C Higher-power photomicrograph demonstrating the appearance of the nuclei of the tumor cells (x 340). HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3-D Photomicrograph showing positive staining of the scattered tumor cells (arrows) for anti-epithelial membrane antigen (x 170). HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4 Electron microscopic image of the biopsy specimen. HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.

Fig. 5 Agarose gel electrophoresis of reverse transcriptase-polymerase chain-reaction products stained with ethidium bromide, demonstrating chimeric SYT-SSX transcripts. HIROAKI HIRAGA et al. J Bone Joint Surg Am 1999;81: ©1999 by The Journal of Bone and Joint Surgery, Inc.