Effect of 21-day Holistic Therapy at “Our Native Village Eco Resorts” on Diabetes Mellitus as assessed by blood glucose levels and consumption of oral hypoglycemic agents Our Native Village Eco Resorts 110, 1 st Floor 2 nd Cross 4 th Main H.A.L III Stage, Bangalore

Sequence Of Presentation Introduction Study Objectives Study End Points Study Procedure Results Clinical data Medication Usage Conclusion

Human body has the inbuilt capability of healing itself completely of diseases. At Our Native Village, an eco-resort for holistic health, an environment is created that is conducive for the body’s self-healing mechanism to work. The fundamental belief behind the 21 day holistic healing program is that the human system in general and the body in specific, has the capability of healing itself completely of diseases of the body, mind and soul. The 21-day holistic health protocol for diabetes practiced at Our Native Village is a combination of ayurvedic therapies, acupressure, naturopathy, sound healing, meditation, yoga, pranayams, mudras, re-birthing breath work, past life regression, and mind body medicine knowledge. Introduction

Primary Objective : Study the effect of 21 day holistic therapy on reduction in blood glucose level. Secondary Objective : Study the effect of 21 day holistic therapy on lipid levels, HbA1c and the consumption of antidiabetic medications. Study Objectives

Study End Points Primary endpoint: Reduction in fasting blood glucose from baseline to end of the study period (21 days). Reduction in postprandial blood glucose from baseline to end of the study period (21 days). Secondary endpoints: Change in HbA1C from baseline to end of the study period (21 days). Change in the use of antidiabetic medications from baseline to end of the study period (21 days). Change in cholesterol, triglyceride, LDL, VLDL, HDL from baseline to end of the study period (21 days).

21 subjects enrolled in the study Parameters measured (at baseline, day 0 and end of study, day 21) o Fasting Blood Glucose Postprandial Blood Glucose HbA1c (glycosylated hemoglobin) Cholesterol Triglyceride Direct LDL cholesterol Very low density lipoprotein HDL cholesterol Antidiabetic medication usage Study Procedure Lab parameters were compared before and after the administration of holistic therapy.

Results Change in Lab parameters at the end of the 21 day Holistic Therapy Sl. noLab Parameters Reduction (No of Subjects) 1Fasting Blood Glucose12 2Blood Glucose, Post-prandial14 3Cholesterol11 4Triglycerides13 5Direct LDL cholestrol10 6Very low density lipoprotein14 7Glycosylated hemoglobin (HBA1C)20

Results: Fasting Glucose Out of 21 subjects enrolled in the study, 12 subjects showed reduction in fasting glucose levels at the end of 21 day holistic therapy. Mean fasting glucose value reduced from mg/dl to mg/dl.

Results: PP Glucose Out of 21 subjects enrolled in the study, 14 subjects showed reduction in postprandial glucose levels at the end of 21 day holistic therapy. Mean postprandial glucose value reduced from mg/dl to mg/dl - a fall of about 29 units.

Results: HbA1c Out of 21 subjects enrolled in the study, 20 subjects showed reduction in HbA1c levels at the end of 21 day holistic therapy. Mean glycosylated hemoglobin showed a decrease from 8.44% to 7.72%.

Results: Triglycerides Out of 21 subjects enrolled in the study, 13 subjects showed reduction in triglycerides level at the end of 21 day holistic therapy. Mean triglyceride level reduced from mg/dl to mg/dl.

Results: VLDL Out of 21 subjects enrolled in the study, 14 subjects showed reduction in VLDL (very low density lipoprotein) level at the end of 21 day holistic therapy Mean VLDL values showed a reduction from to mg/dl.

Maximum Change seen in Lab parameters at the end of 21- day Holistic Therapy Results: Maximum Change

Medication Usage Sl. noStudy ParameterNo. of subjects 1Total number of subjects in the study*21 2Total number of subjects for whom the antidiabetic medications were completely stopped 6 3Total number of subjects for whom at least 1 antidiabetic medication was stopped 6 4Total number of subjects for whom dosage of at least 1 antidiabetic medication was decreased 4 5Total number of subjects with no change in dosage of antidiabetic medication 7 6Total number of subjects with increase in dosage of at least 1 antidiabetic medication** 1 Antidiabetic Medication Usage at the End of Holistic Therapy *No information on prescreening medication for 1 subject and 1 subject was not on any antidiabetic medication. **No information for 3 antidiabetic medications at the end of study period.

Study Conclusion With 21 day dietary therapy (plant based diet) and other modalities of holistic healing like yoga, meditation, acupressure etc., reduction was seen not only in blood sugar levels (fasting and postprandial blood glucose), HbA1c but also some of the lipid profile parameters like triglycerides and VLDL. The consumption of antidiabetic medication was also reduced at the end of the 21 day period. The results of the study conducted by “Our Native Village Eco Resorts” on the effect of 21-day Holistic Therapy on Diabetes Mellitus indicate that the program supporting lifestyle change can be very effective in diabetes prevention and control.