New Faculty Orientation

Office of Research Services (ORS)

Office of Research Services & Research Development Services Helping you navigate your research portfolio 3

Total Dollars Awarded – FY 2008- FY 2012 Millions *2010 includes ARRA awards 5

Office of Research Services (ORS) Research Development Proposal and award processing Pre-award Post award (non financial) Budget review Fit with scope Statutory, fiscal compliance All grant submissions Sponsors: Government, industry, foundations, etc. Modes: Grants.gov, Proposal Central, paper, etc. All grant and contract approvals All negotiations Other agreements Material transfer Professional service agreements Standard information Sponsor policy updates Procedural guidance

Research Development Tools, Resources, and Processes Searchable Databases Limited Competitions Internal Funding Find, apply for, keep your research funding There are both central and departmental level services

Finding Funding Resources to find grants matching your research interests Examples: Pivot-COS Grants.gov Grants Resource Center (GRC) IRIS FedBizOpps 8

Pivot-COS Pivot - Community of Science All disciplines, all sponsor types, international Save multiple, customized funding alerts Track opportunities Matching function Find collaborators http://pivot.cos.com/ 9

(login: uic, pswd: awards) GRC Grants Resource Center Maintains own database and publications that cover all relevant federal grants and many private grants Maintains a library of funded proposals Connect faculty members with program officers www.aascu.org/grc (login: uic, pswd: awards) 10

Limited Competitions Sponsor makes university prescreen and select proposal Peer reviewed – typically evaluated for: Program Compliance Scientific Merit Management Education/Training MUST have prior authorization to submit More sponsors are moving to this method as it lessons the volume of their workload

Limited Competition Process Announcement Letter of Intent White Papers (if necessary) Peer Review ( if necessary) Authorization Feedback (if warranted) This process typically takes from 2 to 4 weeks In general, there will be minimum of ten business days to submit LOI. LOI can be considered a “place holder”, as it is primarily to determine interest. We realize that details can change and that’s fine. IF no one responds by the deadline posted, applicants are approved on a first-come, first-served basis

This is our updated website – the tabs at the top will take you to posted OPPORTUNITIES, an explanation of the PROCESS, POLICIES, AND PROCEEDURES, Template and Instructions for submitting a Letter of Intent, and Instructions for submission of White papers.

Campus Research Board Pilot Grants Up to $20,000 over 1 year Purpose: Foster pilot research Nurture career trajectories of promising early-stage investigators Leverage extramural funding Eligibility: FT tenure or non-tenure track faculty Within 8 years of terminal degree Fall Deadline: LOI: late summer, 2013 Application: Autumn, 2013 http://tigger.uic.edu/depts/ovcr/research/funding/CRB.html#eligibility

Chancellor’s Discovery Fund for Multidisciplinary Research Up to $40,000 over 2 years Purpose: Foster pilot research using the expertise of varied disciplines Nurture career trajectories of promising early-stage investigators Leverage extramural funding Encourage new or support early stage collaborations Eligibility: FT tenure or non-tenure track faculty Minimum of two Principal Investigators At least one PI must be within 8 years of their first faculty appointment FY 13 Deadline: LOI: Fall, 2013 (date TBD) Application: January, 2013 http://tigger.uic.edu/depts/ovcr/research/funding/discovery/

Bridge Funding Program Purpose: short term support to sustain research programs, laboratories, and momentum of productive researchers during funding gaps to give them a chance to regain extramural funding. Eligibility Full time (at least .8 FTE) senior faculty. Preference will be given to Associate Professors Must have been PI on a grant funded at least three consecutive years (the same grant or project) by a national agency with a bona fide scientific peer-review process (e.g. NSF, NIH, AHA) Awards: Vary by Phase 20K for one year or less. Must be matched 1:1   Next deadline: TBD http://tigger.uic.edu/depts/ovcr/research/funding/Seed_Funding/ovcr_bridge.html#awards

Ignite Proposal Development Program Purpose: Spark proposal planning or development process Eligibility Lead PI must be tenured or tenure track faculty and have a full- time (at least .8 FTE) UIC appointment Project must involve 3 or more colleges. Awards: Vary by Phase 20K for a six month term   AY 2013 deadlines: TBD http://tigger.uic.edu/depts/ovcr/research/funding/ignite/

Office of Research Services (ORS) Supports faculty from development to award stage Authorized institutional representative Official institutional endorsements Authorizes all submissions Accepts all awards Negotiates all contracts Government, for profit industry, not for profit foundations Central point of coordination for all sponsored projects for the Chicago, Rockford and Peoria campuses 18

Internal Approvals: Cross your T, Dot your I, CYA The PAF must accompany all applications for external funding. This is not to be used for any internal programs.

ORS - Proposal Approval Form (PAF) Internal routing For ALL proposals Tracks and documents clearances and approvals Identifying information Proposal Type Activity and location Budget information Flags UIC contributions Facilities and administrative (F&A) distribution Budget review and approval Intellectual Property Conflict of interest Signatures Authorized Representative Track awards Establish accounts Grants database Internal routing form – required for ALL PROPOSALS – WHTER OR NOT INSTITUTIONAL SIGNATURE IS REQUIRED, ELECTRONIC TOO. PAGE 1 General information (regarding submission like deadline, electronic submission – ORS uses this information when assigning reviewers. Project contact – this can be a program coordinator or business manager – someone familiar with project and readily available to answer questions that ORS may have prior to submission. Principal Investigator – this is the ONE person responsible for the scientific and technical direction of project. Must be UIC employee and must meet eligibility criteria of sponsor and their respective college. List only co-investigators who are UIC faculty or staff. Project title – be descriptive of scope of work – competing, continuing, revised, and supplemental applications should have the title as the currently funded grant. Page 2 Sponsor info is pretty self-explanatory – please include complete information and don’t use acronyms. Proposal categories – NEW is being submitted for the first time. This can include proposals that were officially rejected during a prior submission and are being resubmitted. CONTINUATION is for a multi-year project that requires a new budget, progress report, etc, in order to receive funding in the consecutive years of the grant – this is also referred to as a NONCOMPETITING application. AMENDMENT is a written agreement used to modify terms of a prior contract. RENEWAL is a proposal for a previously funding project in which funding for a new multi-year project is requested. Also referred to as a competing application. SUPPLEMENT is for funds to augment an already awarded grant or contract – important to include PAF number for original parent grant. REVISION is a revision of a previously submitted proposal based upon a request from sponsor. You can only check one. Type of Award – GRANT is a Unilateral award usually given to accomplish a specific public purpose. CONTRACT is a bilateral legal agreement whereby both parties receive benefit. COOPERATIVE AGREEMENT is created by federal government to permit several different federal and state agencies to financially support a project. You can only check one. TYPE OF ACTIVITY – Three sections – Research, Instruction, and Public Service. All proposals will be grouped in one of these areas. Select only one subcategory under the activity type that best describes the project. CAMPUS – where work will be performed. BUDGET – Summary of direct and indirect costs for year 1 or current year – and then total project costs. Indicate F&A % COST SHARING – indicate sources and percentages. If required by sponsor, must attach documentation from guidelines. Typically, 1/3 split between college, department, and OVCR – requires a MOU. DISTRIBUTION OF CREDIT, F & A ALLOCATION – CREDIT means “Intellectual credit”. If these sections are not completed, 100% of Intellectual Credit and F&A will go to home unit of PI. Percentages must equal 100. PAGE 3 Checklist – this reflects the special clearances that must be secured. Some must be in place at the time of application. This section also provides additional project information. Space – This is to be checked if new space is required to perform the project; if so, need to attach department head letter. You also need to indicate if project requires special energy usage. PAGE 4 Approval – Conflict of Interest Certification – Note: Having a conflict of interest is not inherently problematic; it becomes a problem when it is not disclosed. Parts of this section must be completed/signed by the PI and parts by the Co-Ps. PAGE 5 – Proposal Approval – Official signatures of approval – attest to accuracy and accepting responsibility for conduct of research and to provide necessary reports. NOTE:

Tips for completing PAF Page 1: Project Contact should be familiar with proposal Electronic submission vs. hard copy UIN required for PI and all Co-Investigators if applicable Identification of original source of funds (federal flow through) Program name and number Sponsor Information needs to be complete 21

Tips for completing the PAF Page 2: Project information checklist needs to be completed. One selection per category (ie proposal, award, activity, campus) Identification of budget period Budget totals should match proposal budget Identify any related cost share Distribution of College and Dept F & A Compliance Checklist – Check all that apply: Human Subjects – If applicable, provide Institutional Review Board (IRB) number or identify if “pending” Animals – If applicable, requires ACC protocol number Recombinant DNA – If applicable, require IBC number Hospital/Clinics – If applicable, require hospital administration approval. Allow 5 working days 22

Tips for completing the PAF Page 3: Export Controls Approval/Certifications: Conflict of Interest Certification – PI including any Co- Investigator(s) must mark “yes” or “no” and sign Proposal Approvals: PI and all co-investigators Department Head School/College Dean 23

What are Export Controls?

Export Controls Exports are materials, technology, software and information sent from U.S. to foreign destination  Can be verbal, in writing, by access to items, or even by providing information to a foreign person in U.S. Federal approval must be obtained prior to the export of any covered equipment, materials, technology, software or information. Exemptions include: Fundamental research ordinarily published, shared Public domain information Commonly taught scientific principles Disclosure of unclassified technical data in the U.S. by U.S. institutions of higher learning to foreign FTEs US department of commerce, state, and treasurery Applies to projects that do not meet the test of research being in the public domain Either publication restrictions or limitations on access or dissemination of research results removes “fundamental research” exemption Disclosure policy – “dual use items” – potential militatry use (e.g. missle guidance, avionics, gps, etc) Can also apply to solely civil use items – depending on the end use/end user DEEMED export – giving information to a person who could take it to a different country – if they have access it is termed “deemed” – could apply to visiting scholars, students on foreign travel – what is taken, where it is taken – may just need to register with Department of Commerce EAR – export adminstration regulations ITAR – international traffic in arms regulations – Department of state management required to ship technologies out of the country or in some instances allow access to persons who are not UC citizens or permanent residents

Documents needed to process proposal Minimum documents required to process a proposal: Completed PAF Abstract/Scope of Work Budget NIH Required Documents: Face Page Abstract/Key Personnel Page Budget Justification Checklist Detailed Budget Modular Budget Page (if applicable) 26

Proposal Approval Process Upon receipt, assigned a PAF/ Institution number Proposal assigned to a research coordinator to review accuracy of information and compliance Reviewer endorses documentation on behalf of the authorized institutional official, Dr. Mitra Dutta ORS staff sends electronic notification to department when proposal is ready to be picked up General turn-around time is 1-2 business days after ORS receives complete proposal package 27

Timelines for PAF Approval Paper Submissions: PAF materials to ORS within 3 days of sponsor deadline. Electronic Submissions: PAF materials to ORS within 7 days of sponsor deadline

Things that can delay timely approvals Incorrect budget calculations Missing institutional signatures Lack of institutional approvals

Reminders for your budget Always consult program guidelines as they explain: What can and cannot be budgeting for If there is a cap on the amount that can be requested What indirect cost rate is allowed 30

Distinguishing between Gifts, Grants and Contracts Gift – Unrestricted Funds Grant – Pledge of support for a specific project area, very little if any sponsor involvement and includes specific reporting requirements Contract – A legal binding agreement whereby a specific project outcome is expected, usually involves some level of sponsor involvement 31

Award is here . . . . Now what? Award notices sent to ORS from sponsor ORS highlights special terms and conditions and compares award to request If award differs from request a revised budget is requested from department Revised budget reviewed and approved by ORS and forwarded to Grants and Contracts for account set-up Award and supporting documents sent to PI, business manager and Grants and Contracts 32

What can slow down your award? No proposal/PAF form ever submitted to ORS Awarded budget does not match the proposed budget and you don’t revise budget in a timely fashion The award notice is errantly sent to PI, Department, or Grants and Contracts and not forwarded to ORS Lack of institutional signatures 33

ORS on the Web Research Development Proposal submission Search engines to find funding opportunities Limited competitions Intramural financial resources www.research.uic.edu/funding Proposal submission Standard Information for applications Facilities and Administrative rates (“F & A”) Sample budgets 34

Contact Us: Office of Research Services Luis R. Vargas, Executive Director, lrvargas@uic.edu, 312-996-6150 Amneh Kiswani, Associate Director, Akiswani@uic.edu, 312-996-9406 Tony Halford, Program Coordinator, ahalford@uic.edu, 312-996-7036 ORS Front Desk: 312-996-2862 35

Questions? 36

Office for the Protection of Research Subjects (OPRS) 37

Goals of the UIC Human Subjects Protection Program To ensure a comprehensive Human Subjects Protections Program (HSPP): Utilizing the highest ethical and professional standards Affording the highest possible protections for our human subjects Minimize risk to subjects; and Maximize benefits of the research

What is research? Differing perspectives

Research a systematic investigation including research development, testing, and evaluation; designed to develop or contribute to generalizable knowledge. 45CFR46.102(d)

Human Subjects living individual(s) about whom an investigator (whether professional or student) conducting research obtains: (1) data through intervention or interaction with the individual, or (2) identifiable private information. 45CFR46.102(f)

Note - Only activities that involve both: Research; and Human Subjects are subject to the UIC Human Subjects Protection Program

So, you will be conducting Human Subjects Research at UIC. Now what?....

Tip #1: Utilize Resources Contact OPRS: 312-996-1711 or uicirb@uic.edu On-line Help: “Getting Started - A Guide for Investigators and Research Staff” Link: www.research.uic.edu/protocolreview/irb/getting_started.sht ml

Getting Started – Includes information about: “Human Subjects Research” “Key Research Personnel” Investigator Training requirements The role of the UIC IRB The types of protocol review, including: Determinations Exemptions Expedited IRB Review Convened (full) IRB review Others: Amendments, CR, Prompt Reports Decision Trees (e.g. medical record review research) Research at the Jesse Brown VAMC Tips for obtaining informed consent Helpful links

Tip #2: Complete Investigator Training ASAP Initial Investigator Training (Investigator 101) On-Line via CITI; or In-Person HIPAA Research Training (if research involves PHI) On-Line via LMS; or Note: UIC cannot accept applications unless PI training has been completed and is current. Link to Education and Training: www.research.uic.edu/protocolreview/irb/education/index.shtml

Tip #3: Sign-up for the OPRS Newsletter Sent electronically every other month News for Investigators Tips for Investigators QIP Corner Continuing Education Opportunities UIC Data Security Policy Information Archived on OPRS Web-site Sign up: Contact OPRS Assistant to the Director, Nora Cortes: nreyes@uic.edu

Contact Us West Side Office: Room 203B, AOB, 1737 West Polk Street Phone 312-996-1711 Email: uicirb@uic.edu East Side Satellite Office (M,W 2 – 4 pm) Room 3108A, BSB Phone 312-996-7742 URL: www.research.uic.edu/protocolreview/irb

Questions? 49

Office of Animal Care and Institutional Biosafety (OACIB) 50

Animal Care Committee (ACC) Office for Animal Care and Institutional Biosafety OACIB provides administrative support for the review and approval of research protocols (experiments) involving animals, recombinant DNA and infectious agents, and ensures compliance with regulations related to the use of controlled substances in animal and laboratory research. The goal of the office is to facilitate the protocol writing/review process and navigation of the regulatory issues to ensure compliance with the regulations for the protection and welfare of animals, protection and safety of investigators, and the University. Animal Care Committee (ACC) Animal Care Committee (ACC) Oversight for all use of all live vertebrate animals in Research Testing Teaching OLAW/NIH USDA AAALAC SPONSOR GUIDE ILAR DEA IDPR

Institutional Biosafety Committee (IBC) Office for Animal Care and Institutional Biosafety OACIB provides administrative support for the review and approval of research protocols (experiments) involving animals, recombinant DNA and infectious agents, and ensures compliance with regulations related to the use of controlled substances in animal and laboratory research. The goal of the office is to facilitate the protocol writing/review process and navigation of the regulatory issues to ensure compliance with the regulations for the protection and welfare of animals, protection and safety of investigators, and the University. Institutional Biosafety Committee (IBC) Institutional Biosafety Committee (IBC) Oversight of all research involving rDNA Infectious agents/toxins Select Agents (EHSO) OBA CDC USDA

Office for Animal Care and Institutional Biosafety Who needs a protocol? Responsibilities? Protocol approval is required prior to Prior to initiation of any use of animals JIT or acceptance/transfer of a funding award proposing the use of animals simultaneous with the initiation of some rDNA work (e.g. in vitro BSL 1) prior to the initiation of some rDNA work (e.g., all viral vectors, use in animals, use in humans) prior to the initiation of all infectious agent work Protocols are needed if research involves the use of animals, rDNA, &/or infectious agents and is conducted at UIC, or is conducted by UIC students &/or paid personnel, or is conducted using funds administered by UIC including subcontracts and consortiums.    

Who needs to be on the protocol? Office for Animal Care and Institutional Biosafety Who needs to be on the protocol? Responsibilities? Personnel need to be listed on a protocol if they are: PI PI of a grant supported by the protocol (must be Co-PI on the protocol. PPG, Form G protocol exceptions) Working in any capacity with live animals or with rDNA/IA Research Coordinators who need to receive copies of correspondence from OACIB related to protocol issues. Know what is approved on the protocol- species/strains specific procedures specific experiments specific endpoints or monitoring no migration Have expertise or get appropriate training in techniques/procedures to be performed Get approval for changes prior to initiation    

Office for Animal Care and Institutional Biosafety Facilitating excellence in research at UIC ACC Forms and Training Process and Timing Protocols Form A* Form B Form C Form G Appendix 1a, 1b, 1c Appendix 2 Appendix 3* Modifications Form D Training ACC Project Specific Protocols ~ 6 weeks No expedited Review Vet Subcommittee Full Committee Modifications Administrative - 3-7 days Designated Reviews - 1-6 weeks Full     55

Office for Animal Care and Institutional Biosafety Facilitating excellence in research at UIC IBC Forms and Training Process and Timing Protocols Form A Form B Form D Appendix 1 BSL1 Manual BSL2 Manual Modifications Form C Training BBP DOT/IATA Select Agents Protocols 2 weeks Prereview Expedited Full Modifications - 3-7 days -1-4 weeks    

Office for Animal Care and Institutional Biosafety Facilitating excellence in research at UIC Post-Approval ACC Post-Approval IBC Animal Facility Orientation Occupational Health Card Access Account Creation Animal Orders Approved Unapproved DEA Licenses Modifications Form D Annual Renewal Triennial Review Lab Inspections BSC Certifications Modifications Form C Annual Training Triennial Review    

Office of Animal Care and Institutional Biosafety Web Sites ACC: www.research.uic.edu/protocolreview/acc/index.shtml IBC: www.research.uic.edu/protocolreview/ibc/index.shtml Controlled Substances: www.research.uic.edu/protocolreview/cs/index.shtml Meeting Dates Forms Education/Training Policies/Guidance FAQs Online Resources Contact Information

AAALAC OBA USDA OHSA FDA OLAW OHRP Office of the Vice Chancellor for Research Facilitating excellence in research at UIC AAALAC OBA Chemicals Controlled Substances USDA Humans Toxins Animals OHSA Agents Select FDA Lasers OLAW Radioactivity X-rays Infectious agents rDNA OHRP

Regulations Pertaining to Research Office of Animal Care and Institutional Biosafety Regulations Pertaining to Research Animals rDNA Infectious Agents Toxins- Biological Controlled Substances Select Agents Humans Chemicals Radionucleotides X-rays/Irradiators Lasers Embryonic Stem Cells Conflict of Time/Commitment Conflict of Interest Import/Export Material Transfer

Contact Us Office of Animal Care and Institutional Biosafety Mary Bowman, PhD, Director Room 206 AOB 1737 W. Polk Phone: 312.996.1972 Email: mbb@uic.edu

Questions?

Conflict of Interest (COI) 63 63

Conflict of Interest The Changing Environment Main Points Federal regulations University Policy Main Points COI Defined COI and RNUA Reporting and Managing Conflicts COI Resources

What is financial conflict of interest? “A ‘conflict of interest’ arises when an academic staff member is in a position to influence either directly or indirectly University business, research, or other decisions in ways that could lead to gain for the academic staff member, the staff member's family, or others to the detriment of the University's integrity and its missions of teaching, research, and public service.” “Family" is defined as one's spouse or domestic partner, parents, siblings and children. Conflicts reside in a situation, and do not imply improper behavior.

Conflict of Interest Who is covered by the policy? “All paid academic staff members, whether part time or full time, of the University of Illinois. The academic staff includes the faculty ranks of professor, associate professor, assistant professor (and all of the foregoing whose appointments contain such terms as 'research,' 'adjunct,' 'visiting,' or 'clinical'), instructor, and lecturer, as well as academic professionals and postdoctoral associates.” Any paid, non-0% appointment. Students, including medical residents, are not considered academic staff.

Conflict of Interest Report of Non-University Activities (RNUA) Annual Reporting of Non University Activities is the implementation of conflict of interest policies and regulations for both conflict of interest and conflict of commitment. All academic staff complete the form, even if there are no outside activities to disclose. 24/7 during the contract period. Resolution always begins with RNUA disclosure and sometimes involves a combination of conflict management techniques.

Conflict of Interest PHS FCOI Regulations (2011) These regulations require HHS, PHS, and NIH Investigators and senior/key research personnel to:   Disclose significant financial interests (SFIs) at the time of proposal submission Disclose sponsored or reimbursed travel at the time of proposal submission Update disclosures within 30 days of any newly acquired or discovered SFIs Manage Financial Conflicts of Interest (FCOI) prior to execution of an award or continuing review Complete mandatory University training on Financial Conflicts of Interest (FCOI)

Conflict of Interest How to report and manage COI Annual Disclosure Annual Report of Non-University Activities (RNUA) RNUA-Management Plan (RNUA-MP) for situations that require more management (e.g., faculty involved in start-up companies). HHS/PHS/NIH – Significant Financial Interest – Disclosure and Management Plan: Part I SFI-DMP: Part II when University designated officials determine SFI represent a FCOI Transactional Disclosure PAF – COI Certification IRB protocols applications – COI section

Conflict of Interest How to report and manage COI Unit Executive Officer Holds primary responsibility for working with the academic staff members to manage conflicts. UIC Conflict Review Committee (CRC) Advisory to the Vice Chancellor for Research. Reviews RNUA-management plans and other management plans as needed COI-Human Subject Research (COI-HSR) Committee Expedited review of COI disclosures on IRB protocols Makes recommendations to the IRB.

Conflict of Interest COI Resources Online All RNUA materials (forms, instructions, more) Managing conflicts (templates, instructions, committee info) Policy, rules, regulations FAQs In Person Phone, email help Strategy, guidance, and oversight meetings Educational presentations

Contact US Jacquelyn Jancius, COI Director Phone: 312-996-4070 Email: coi@uic.edu Scott MacEwen COI Coordinator Phone: 312-996-3642 www.research.uic.edu/conflict

Questions? 73 73

Research Integrity 74

Research misconduct at top-tier research institutions raise public concerns about policing scientific integrity 1970s William Summerlin, Memorial Sloan-Kettering Cancer Center the painted mice 1980 Elias Alsabati, six different US research intitutions >80 plagiarized and fraudulent papers Marc Straus, Boston University falsified patient eligibility for clinical trials Vijay Soman, Yale Medical School falsified and fabricated data plagiarized a rival’s paper John Long, Massachusetts General Hospital falsely represented monkey cells as human

Fraud in Biomedical Research March 1981 Congressional Oversight Hearings Al Gore, Jr. , Chair, Investigations and Oversight Committee of the House Science and Technology Committee Philip Handler, President of NAS: “The system succeeds in policing itself” Donald Frederickson, Director of NIH: [no congressional mandate for regulation of research]…is necessary, for the natural sciences contain ultimate correctives for any debasement of the knowledge derived from research.”

Integrity in Research and Publication Goal promote compliance with the highest scholarly standards Purpose provide impartial fact-finding and fair adjudication of allegations of research misconduct Policy UI Policy and Procedures on Integrity in Research and Publication http://www.vpaa.uillinois.edu/policies/Integrity-Policy.pdf UI Policy incorporates federal regulations and PHS guidelines 42 CFR 93 (rev. 2005) http://www.gpo.gov/fdsys/pkg/CFR-2006-title42-vol1/pdf/CFR-2006- title42-vol1-part93.pdf

1985 Health Research Extension Act (Section 493) HHS regulation requires that institutions establish: process to review allegations research misconduct report investigation of alleged research misconduct to the federal government

Integrity in Research and Publication Research Misconduct includes fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results. Fabrication: making up data or results and recording or reporting them Falsification: manipulating research materials, equipment, or processes, or changing or omitting data or results such that the research is not accurately represented in the research record. Plagiarism: appropriation of another person’s ideas, processes, results or words without giving appropriate credit Does not include honest error or difference of opinion

Integrity in Research and Publication Research Misconduct also includes, but is not limited to, the following: intentionally misleading or deliberately false reporting of credentials and related information abuse of confidentiality with respect to unpublished materials misappropriation of research materials evasion, or intentional failure to comply after notice with research regulations, such as those governing conflict of interest/commitment, human subjects, laboratory animals, new drugs, radioactive materials, genetically altered organisms, and safety any other conduct that constitutes a serious deviation from accepted ethical guidelines and professional standards in scholarship and research

Integrity in Research and Publication Any member of the University community who has information related to potential Research Misconduct has a duty to report such information to the Respondent’s Unit Executive Officer, or to the RIO Members of the University community shall cooperate with the RIO and other institutional officials in the review of allegations and the conduct of inquiries and Investigations. Institutional members, including Respondents, have an obligation to provide evidence relevant to Research Misconduct allegations to the RIO or other institutional officials.

Contact US Mark D. Grabiner, PhD Associate Vice Chancellor for Research and Research Integrity Officer Phone: 312-996-2757 Email: grabiner@uic.edu Website: www.vpaa.uillinois.edu/Policies/integrityresearch/index.cfm

Questions? 83

Research Resources Center (RRC) 84 84

Assures accessibility of shared resources to all researchers in the UIC community Serves >1,000 investigators, $160M 013 grants $8 M operating budget, 35-40% subsidy 60 staff; full-time PhD lab directors in each facility Faculty Academic Directors East and West Campus central facilities

Recent Advancements $12M new capital equipment since 2010 New Imaging Center: 2 of Latest Zeiss Confocals, Prairie Multiphoton Scope, Vectra tissue imaging JEOL ARM-200CF Aberration-corrected STEM: very high resolution EM Small animal imaging: 9.4T MRI, IVIS live animal imager, VEVO Echo 4 new Mass Specs: Orbitrap Velos Pro, Agilent triple quad, AB Sciex 5500, 6500 New Genomics Center: Sequenome; Gene Titan HT Genotyping; Ion Torrent, Proton Next-Gen; digital PCR Drug Discovery Center: High-throughput Screening

Center for Structural Biology Director: Yoshitaki Ishii, Technical Director: Ben Ramirez NMR: 600, 750, 800, 900 Mhz Small molecule and macromolecular XRD, X-ray Crystallography Biacore molecular interaction analysis Analytical Ultracentrifugation, Calorimetry, Fluorescence Production and purification of proteins

Confocal Microscopy Facility Peter Toth, Technical Director, Ke Ma, associate Director The Confocal Microscopy Facility will work to accommodate any biological research that requires light, deconvolution, confocal, TIRF, and/or widefield fluorescent microscopy. State-of-the-art imaging technology for fixed and live cells and tissues. Imaging techniques: live-cell, confocal, FRET, FRAP, FLIP, TIRF, PhotoActivation, and real time recording of micro- injection. Instruments: Confocals: Two new Zeiss LSM710, Zeiss 510Meta Olympus VivaView live-cell long-term imaging system Prairie Systems Multiphoton microscope Zeiss TIRF System: Newly upgraded; total internal reflection fluorescence; high-resolution imaging of signals near biological membranes. AIS2 automatic microinjection system: high injection rates of 1,500 cells per hour. Newly rennovated space: 2500 sq ft, microscopy suites Contact: RRC-imaging@uic.edu

ELECTRON MICROSCOPY SERVICE Director: Robert Klie, Technical Director: Alan Nichols Scanning (SEM), transmission (TEM) and scanning transmission (STEM) electron microscopes as well as Raman spectroscopy and surface analysis (XPS) Two laboratories: E5, Medical Sciences Building - SEM and Life Science TEM Room 116, SES - Materials Science TEM/STEM, Microprobe, Surface Analysis & Raman NEW: JEOL JEM-ARM200CF TEM/STEM with cold field emission source CEOS probe aberration corrector

Flow Cytometry Service FCS Balaji Ganesh, Director The Flow Cytometry Service is a full service facility with seven flow cytometers. We provide flow cytometry services for analysis and sorting of cells, as well as training and expert consultation for project/experiment planning. High speed sorters: Beckman MoFlo; new cell sorter soming soon Bio-Rad Bio-Plex for multiplex quantitative assays 5 flow cytometry analyzers: new BD Fortessa, new Beckman Gallios Staff Jewell Graves, Lab Manager Juan Chen, Research Specialist Lakshmy Ganesh, Research Specialist Bio-Rad Bio-Plex Beckman Coulter Cyan ADP Appointments can be made for instrument instruction, sorts, and use of our flow cytometers on the FCS Online scheduler proteomics.rrc.uic.edu/flow. Raw data and analysis files will be sent on line to with the "MY DATA" server. Types of analysis Immunophenotyping, DNA content, cell cycle analysis, DNA ploidy analysis, apoptosis, phagocytosis, intracellular pH, calcium levels, oxidative burst, intracellular antigen measurement, total protein, cytokine detection, intracellular signaling and isolation of rare cell populations including human and animal stem cells. Becton Dickinson Fortessa Beckman Coulter MoFlo

Transgenic Production Service The Transgenic Production Service provides a resource for investigators seeking to generate transgenic and gene-targeted mice for their research activities. DNA Microinjection/Transgenics ES Cell Microinjection/Chimeric mice ES cell expansion Gene Targeting in ES cells Embryo & Sperm Cryopreservation Recovery of Pups from Cryopreserved Embryos Recovery of Pups from Cryopreserved Sperm In Vitro Fertilization (IVF)

Animal Imaging and phenotyping Preclinical MRI Facility: 2,000 sq. ft. animal imaging laboratory equipped with a new Agilent 9.4 Tesla MRI system that is able to image small animals and samples up to 7.5 cm in diameter. The Xenogen IVIS® Spectrum in vivo imaging system uses optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. CCVR: Surgical services: Trans aortic constriction; Coronary artery ligation; Osmotic plant implantation Imaging: VisualSonics Vevo770 ultrasound

Research Histology Core (RHC) Director: Andy Hall COMRB 1120 Services Available Tissues embedded in paraffin and processed for sectioning Training and consultation available for by phone, e-mail or in person. Antibody testing for determination of optimal conditions Immunofluorescence of cultured cells Fluorescent or colorimetric detection of antigens by immunohistochemistry TUNEL staining in fixed sections for apoptosis studies Routine Hematoxylin and Eosin staining of tissue sections Specialized stains, such as the Gomori Trichrome Stain Sample preparation/OCT freezing for cryosectioning Tissue preparation for electron microscopy Imaging: Nikon E400 fluorescent microscope equipped with a SPOT color camera. 3 microtomes: Do your own or we do the work for you Routine histology staining or immuno-histochemical staining Dual staining of Connexin 26 (green) and cytokeratin (red) in the baboon endometrium. Microm Vacutome Cryostat service, or can be reserved to do your own sectioning Immunohistochemical localization of cFOS in the baboon endometrium visualized with DAB. Ha Nikon Eclipse E400 Epi-fluorescence microscope, Contact Andy Hall www.rrc.uic.edu/rhc

Biorepository Institutional resource for processing and storing human tissue samples for research purposes. New LN and -85 freezers house blood, serum, plasma, urine, nucleic acids, & PBMC specimens IRB-approved opt-in protocol Specimens are banked in compliance with IRB- approved protocols and HIPAA standards Investigator protocols; 10 current, others in IRB Staffing: Director 2 Pathologists 2 Path Assistants 2 Techs SERVICES INCLUDE: Separation of whole blood derivatives serum, plasma, PBMCs, urine, and saliva. Nucleic Acid isolation using iPrep™ Opt-in or PI protocol; all samples bar coded and annotated Specimen management database moving from caTissue to OnCore Secure storage of samples/data

BioInformatics Service Director: Ives Lussier, Technical Director: Neil Bahroos For analysis of big datasets from Genomics/Sequencing Resources Integrated with Genomics, computing IT and Biorepository Staff: 4 Bioinformaticians specializing in analysis of genome sequencing, gene expression, genotyping, pathways Computing resources Mixed cluster (GPU/CPU) HPC coming soon UIUC computing resources New 3,000 sq ft facility in CME

Center for Genomic Research Staff: Co-Directors, 8 full time technicians, 4 students Budget: $1.6M/yr Services: Next-Generation Sequencing CE Sequencing Quantitative analyses- QPCR and Digital PCR Automated Nucleic Acid purification and QC Gene expression analysis High Throughput Genotyping, CNV Cytogenomics

Select Capabilities Whole genome sequencing (De novo and re-sequencing) Ion Torrent Proton and PGM (UIC) Illumina HiSeq2000, Roche 454 (UIUC) Target capture (custom/cancer panel/exome) Agilent SureSelect / Haloplex (hybridization capture) Ion Torrent Ampliseq / Qiagen Generead (PCR-based) ChIP-seq: Sample prep with Covaris acoustic shearing Microbiome Analysis: Ribosomal RNA gene sequencing Genotyping: Affymetrix Gene Titan: 96 sample 2.2M microarray Sequenome: 768 sample throughput Transcriptome sequencing Differential gene expression Detection of novel transcripts Illumina HiSeq / Ion Torrent Proton MicroRNA: Ion Torrent Proton; TILDA microfluidic arrays Quantitative mRNA expression analysis Affymetrix Quantigene Plex: 3 to 80-plex; 96-sample throughput Affymetrix micro array Cytoscan Affymetrix cytogenetic profiling

Mass Spectrometry, Metabolomics and Proteomics Richard van Breemen, Academic Director; Alex Schilling, Technical Director Primary Staff: Rod Davis, Jerry White Other Instrumentation New Triple Quad ABSciex 5500 Shimazdu IT-TOF MSn JOEL GC-MATE MS Thermo TSQ Quantum QQQ MS-MS Agilent HPLC Chip Cube Interface Agilent 1946C MSD MS Thermo LCQDeca MSn Waters SCF-MS Shimazdu LCMS 8030 QQQ MS-MS Agilent Off-gel Thermo LTQ MSn Services Provided Accurate Mass Measurement LC-MS and LC-MS-MS MALDI MS and MS-MS Quantitative Analysis Structure Elucidation Protein Identification Metabolite Identification Thermo LTQ-FT LC/MS/MS Informatics Tools Mascot & SEQUEST search engines Scaffold report generation: easier to interpret, interact with your results Self-serve informatics workstations BioWorks and file conversion tools X!Tandem searches Specialized tools, customized databases 2 Agilent 6410 Triple quads ChipCube system Waters Synapt QTOF MS; ion mobility Thermo Velos Orbitrap Pro funded by NCRR Fitted with Chip Cube

Scientific Instrumentation Shop Director: Eric Schmidt The Scientific Instrument Shop (SIS) is staffed by Instrument Makers, Senior Laboratory Mechanics, and Biomedical Electronics Engineers who construct and repair all types of mechanical and electronic/electrical equipment for the research, teaching and clinical requirements of faculty, staff and students. Machine Shop Skilled Instrument Makers will assist designing and/or fabricating items utilizing the latest CAD/CAM software; full 3-axis and 3-D contour milling. Materials: stainless and alloy steels, titanium, lead, platinum, brass, aluminum, copper, sheet metal plastics: acrylic, acetate, acetal, polypropylene, polystyrene, nylon, PVC, teflon, polycarbonates, polyethylene, engineered plastics wood, wood composites and machinable ceramics. Electronics Shop: complete electronic services including the maintenance and repair of electronic devices. We also design and fabricate customized electronic equipment that may not be commercially available. Staff   Eric Schmidt Director Schmidte @uic.edu Services Tig welding of most metals Brazing silver solder Sandblasting Thermocouples Repair and rebuilding Fabrication of parts- most plastics machining, plastic welding/gluing, bending and polishing Capabilities: Turning in lathe up to 15" Manual milling 2 axes and 3 axes CNC milling Surface grinding Precision thread cutting Sheetmetal bending Forming, shearing and fabrication Hole punching Woodworking — sawing and fabrication Matthew Schuck, Instrument Maker John Grega, Biomedical Engineering Technician

Contact US William Hendrickson Director, RRC Phone: 312-996-5600 Email: whend@uic.edu Website: http://www.rrc.uic.edu/

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Biologic Resources Laboratory (BRL) 103 103

Biologic Resources Laboratory UIC’s Centralized Animal Research Facility Oversight of the institution’s animal care and use program Support research Daily care and husbandry of all laboratory animals Procurement of all animals Ensure animal welfare Ensure compliance with regulatory agencies Ensure the health status of animal colonies Train students, staff, and faculty

Biologic Resources Laboratory UIC’s Animal Care and Use Program has been continually accredited by AAALAC International since 1970. Oldest and most successful training programs for laboratory animal veterinarians Active professional staff Professional organizations Teaching Research Service

Biologic Resources Laboratory Program Scope 137,000 sq. ft. 10 satellite facilities House over 20 species Ave. daily census 32,000 animals Mice 30,000 Primates 175

Biologic Resources Laboratory Program Scope Staff - 64 11 vets – 5 board certified, 6 post-docs 8 veterinary technicians 37 husbandry staff 6 administrative staff 1enrichment specialist 1 machinist

Biologic Resources Laboratory Animal Based Research Scope 275 investigators 700 active research protocols Types of studies Cancer Immunotherapy Radiobiology Infectious disease TransplantationHeart Disease Diabetes Neurologic disease Retinal diseases

Biologic Resources Laboratory Services To gain access to any of the facilities Listed on an approved ACC protocol Orientation with one of the veterinarians Visit employee health and enroll in the occupational health and safety program

Biologic Resources Laboratory Services Centralized surgery Diagnostic laboratory Radiology section Antibody production service Cross foster rederivation program Support Good Laboratory Practice Studies Support bio and chemical hazard work Irradiator Metabolic cages Rodent quarantine Resource

Biologic Resources Laboratory Main phone number 312-996-7040 Website http://www.brl.uic.edu/ Key contacts Fee schedule Animal per diem rate Diagnostic lab services Surgery services Jeffrey Fortman, Director Biologic Resources Lab 312-996-1220 jdf@uic.edu

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