Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis Benjamin P. Duckworth, Todd W. Geders, Divya Tiwari, Helena.

Slides:



Advertisements
Similar presentations
Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole- Cell Screening Garth L. Abrahams, Anuradha Kumar, Suzana Savvi, Alvin.
Advertisements

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.
Binocular rivalry Colin W.G. Clifford Current Biology Volume 19, Issue 22, Pages R1022-R1023 (December 2009) DOI: /j.cub Copyright ©
Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,
Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS Kentaro Takahama, Asami Takada, Shota Tada, Mai Shimizu,
The Biosynthesis of Teicoplanin-Type Glycopeptide Antibiotics: Assignment of P450 Mono-Oxygenases to Side Chain Cyclizations of Glycopeptide A47934 Bianka.
Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants Qihua Ling, Paul Jarvis Current Biology.
Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &
Ancient Endo-siRNA Pathways Reveal New Tricks Julie M. Claycomb Current Biology Volume 24, Issue 15, Pages R703-R715 (August 2014) DOI: /j.cub
The Circadian Timekeeping System of Drosophila Paul E. Hardin Current Biology Volume 15, Issue 17, Pages R714-R722 (September 2005) DOI: /j.cub
Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas.
Nitric Oxide-Mediated Histone Hyperacetylation in Oral Cancer: Target for a Water- Soluble HAT Inhibitor, CTK7A Mohammed Arif, Bhusainahalli M. Vedamurthy,
Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics
Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis Tim J. Wigle, Laurel M. Provencher, Jacqueline.
In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.
A Fluorescent Hydrogel-Based Flow Cytometry High-Throughput Screening Platform for Hydrolytic Enzymes Christian Pitzler, Georgette Wirtz, Ljubica Vojcic,
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria Anthony D'Onofrio, Jason M. Crawford, Eric J. Stewart, Kathrin Witt,
Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking Peter Daldrop, Francis E. Reyes, David A. Robinson, Colin M. Hammond, David M. Lilley,
A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.
Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.
Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,
Telomerase Inhibitors Identified by a Forward Chemical Genetics Approach Using a Yeast Strain with Shortened Telomere Length Ryuichiro Nakai, Hiroyuki.
Healthy clocks, healthy body, healthy mind Akhilesh B. Reddy, John S. O’Neill Trends in Cell Biology Volume 20, Issue 1, Pages (January 2010) DOI:
Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.
Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.
Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers Gurushankar Chandramouly, Shane McDevitt, Katherine.
Titration-Based Screening for Evaluation of Natural Product Extracts: Identification of an Aspulvinone Family of Luciferase Inhibitors Patricia G. Cruz,
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA Moriz Mayer, P. Therese Lang, Sabina Gerber, Peter B. Madrid, Irene.
LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions Takayuki Miki, Sho-hei Fujishima, Kazuhiro.
Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene Shilah A. Bonnett,
The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.
Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage John Tam, Greg L. Beilhartz, Anick Auger, Pulkit Gupta, Alex G. Therien,
Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers George P. Tegos, Tatiana N. Demidova, Dennisse Arcila-Lopez, Haeryeon Lee,
The Origins and Evolution of Vertebrate Metamorphosis Vincent Laudet Current Biology Volume 21, Issue 18, Pages R726-R737 (September 2011) DOI: /j.cub
Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.
Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)
Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes Edgar Deu, Melissa J. Leyva,
Nucleosomes and Cisplatin
Volume 22, Issue 5, Pages v-vi (May 2015)
Now Playing: Farnesol in the Biofilm
Enzyme Annotation with Chemical Tools
Tailor-Made Peptide Synthetases
Nucleosomes and Cisplatin
On-Bead Library Screening Made Easier
Antibiotics: A New Hope
Foundations for Directed Alkaloid Biosynthesis
Chemical Proteomics of Host-Pathogen Interaction
Adding Specificity to Artificial Transcription Activators
Finding the Missing Code of RNA Recognition by PUF Proteins
Activity-Based Profiling of 2-Oxoglutarate Oxygenases
Targeting the Undruggable Proteome: The Small Molecules of My Dreams
Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone
No Need To Be Pure: Mix the Cultures!
Activity-Based Profiling for Drug Discovery
Now Playing: Farnesol in the Biofilm
BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons
Making a New Turn In Matrix Metalloprotease Inhibition
Volume 21, Issue 8, Pages v-vi (August 2014)
Volume 18, Issue 11, Pages (November 2011)
Foundations for Directed Alkaloid Biosynthesis
Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets  Andrew T. Krueger, Eric T. Kool  Chemistry.
L-DOPA Ropes in tRNAPhe
Volume 21, Issue 9, Pages (September 2014)
Tools to Tackle Protein Acetylation
Volume 21, Issue 9, Pages (September 2014)
Presentation transcript:

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis Benjamin P. Duckworth, Todd W. Geders, Divya Tiwari, Helena I. Boshoff, Paul A. Sibbald, Clifton E. Barry, Dirk Schnappinger, Barry C. Finzel, Courtney C. Aldrich Chemistry & Biology Volume 18, Issue 11, Pages (November 2011) DOI: /j.chembiol Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Figure 1 Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Figure 2 Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Figure 3 Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Figure 4 Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions Terms and Conditions

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com Inc. All rights reserved.