BREAST CANCER PROF.NAZEM SHAMS
IS IT A SERIOUS PROBLEM ??
TYPES OF BREAST CANCER In situ Intraductal (DCIS) Intralobular (LCIS) Invasive Infiltrating ductal carcinoma Tubular carcinoma Medullary carcinoma Mucinous carcinoma
PRESENTATION :
CANCER BREAST Skin manifestations: 1) Skin dimpling, Tethering & Puckering:- 2) Skin fixation, ulceration & fungation 3) Nipple retraction: 4) Paget's disease of nipple 5) Peau d’orange: 6) Cancerous satellite nodules (late sign) 7) Cancer en cuirasse (very late sign) 8) Mastitis carcinomatosa 9) Malignant edema of upper limb (brawny arm) 10) Dilated veins
CYSTSARCOMA PHYLLOIDE TUMORS
dimpling
Nipple retraction
Paget disease
Eczema
Peau d’orange
ulceration & fungation
Mastitis carcinomatosa
satellite nodules
Cancer en cuirasse
edema of upper limb
Winging of the scapula
RISK FACTORS OF BREAST CANCER
BREAST CANCER PATHOLOGY
Tx No evidence of primary tumor Tis Carcinoma in situ T1 Tumor 2cm or < T22 to 5 cm T3T> 5cm T4a extension to chest wall T4b edema (including peau d’orange), ulceration of skin, satellite nodules T4c T4a + T4b T4d Inflammatory carcinoma
N0no regional lymh node met. N1Movable ipsilateral axillary l.nod. N2Fixed ipsilateral axillary lymph n. or İnternal mammary lymh nodes N3-İpsilateral supraclavicular l.n. -Fixed ipsilateral axillary lymph n. and İnternal mammary lymh nodes -İpsilateral infraclavicular l.n.
M0 M1
STAGE 1 Tumor < 2.0 cm in greatest dimension No nodal involvement (N0) No metastases (M0)
STAGE II Tumor > 2.0 < 5 cm or Ipsilateral axillary lymph node (N1) No Metastasis (M0)
STAGE III Tumor > 5 cm (T3) or ipsilateral axillary lymph nodes fixed to each other or other structures (N2) involvement of ipsilateral internal mammary nodes (N3) Inflammatory carcinoma (T4d)
STAGE IV (METASTATIC BREAST CANCER) Any T Any N Metastasis (M1)
INVESTIGATIONS :