MARK BARTLETT, PHD Vice President, Global Research and Development Pharmanex

Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business opportunity through PRODUCT INNOVATION

Science in product development – Discovery process – Development process Scientific assets – Multiple unique tools to discover and develop anti-aging products with meaningful benefits Our anti-aging product strategy is to leverage LEADING EDGE SCIENCE to further understand the aging process.

FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a pre- clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, Les Diablerets Conference Center, Les Diablerets, Switzerland. GENE EXPRESSION IN YOUNG TISSUE GENE EXPRESSION IN OLD TISSUE OLD GENE EXPRESSION AFTER AGELOC Low Expression High Expression Gene Expression Scale AGELOC GENE TECHNOLOGY

Our Science, Your guarantee – Quality – Innovation – Safety – Substantiated claims 6S Quality Process Selection; Sourcing; Standardization; Safety; Structure; Substantiation

TOOLKIT ageLOC science 6S process ANTI-AGING PRODUCT DEVELOPMENT PROCESS

R&D ENGINE - PROVO INNOVATION CENTER 8

9 R&D ENGINE CHINA INNOVATION PARK

NEW ANTI-AGING AGELOC TOOLS LifeGen Patented technologies to study anti-aging interventions through gene expression science Acquired November 2011 NOX Technologies Patented anti-aging technology Incorporated in ageLOC Transformation and Galvanic Gels Acquired November 2012

Nutrition Science Antioxidant Science Healthy Aging Gene Science ???

AGELOC GAMMA: WEIGHT MANAGEMENT SYSTEM AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene expression science ageLOC Gamma helps you look slimmer and healthier in 90 days when used in conjunction with a healthy diet and exercise Simple Eating & Lifestyle Plan Advanced ageLOC Products

AGELOC GAMMA: INFLUENCING WEIGHT Key Tissues – There are key tissues that address critical areas of weight loss through gene expression. ageLOC Gamma will focus on these key tissues

AGELOC GAMMA

AGELOC GAMMA: STUDIES LifeGen (gene expression science) – Gene array analysis to elucidate YGCs Clinical Studies – Open label study (ongoing) – Larger trial (starting in 2013)

GAMMA SYSTEM 18 Incorporating ageLOC science and clinically demonstrated ingredients

AGELOC GAMMA REPRESENTS A MAJOR INNOVATION WITH GENE EXPRESSION SCIENCE

S3: SCANNER UPGRADE COMING SUMMER % smaller Wireless Battery operated

FUTURE PIPELINE INNOVATIVE ageLOC SKIN CARE and NUTRITION

AGELOC INNOVATION PATTERN