College of Pharmacy Research Activities

University of Illinois at Chicago College of Pharmacy UIC University of Illinois at Chicago

University of Illinois at Chicago College of Pharmacy UIC Where are we?

University of Illinois at Chicago College of Pharmacy UIC Medical Campus

University of Illinois at Chicago College of Pharmacy UIC College of Pharmacy Then: Now:

University of Illinois at Chicago College of Pharmacy UIC Research Success UIC ranks in the top five nationally out of 83 colleges of pharmacy Between 1998 and 2002 the College expanded research grants and contracts by an average of 11.6% per year Grants and Contracts Awarded ($ in Millions) Fiscal Year The College of Pharmacy continues to enhance its research base Source: Comparative 2002 Survey, Research-Intensive Colleges of Pharmacy

University of Illinois at Chicago College of Pharmacy UIC Research – Source of Funds – FY 2002 $14.3M total in awards - NCI is $5.3M of $9.6M NIH total NCI is $5.3M of $9.6M NIH total Source: COP external awards database

University of Illinois at Chicago College of Pharmacy UIC COP Research Capabilities Research Disciplines  Drug discovery / natural products  Drug development / natural products  Drug delivery  Molecular target discovery  Pharmacogenomics  Biotechnology / biodefense  Pharmacoeconomics / Patient outcome management Disease States  Cancer  Cardiovascular  Infectious diseases  Neurosciences / neurodegenerative diseases  Immunology / Transplant medicine

University of Illinois at Chicago College of Pharmacy UIC Organization Andrew Donnelly Director Hosp. Pharm Srv. Jerry Bauman Dean Jan Engle Head Pharmacy Practice Nicholas Popovich Head Pharmacy Administration William Beck Head Biopharmaceutical Sciences Judith Bolton Acting Head Medicinal Chemistry and Pharmacognosy Steve Swanson Acting Associate Dean for Research and Graduate Education James Fischer Director Ciln. Res. Lab. Ken Wittee Director Amb. Care Srv. Norman Farnsworth Director PCRPS & Botanical Ctr. Michael Johnson Director Ctr. Pharm. Biotech. Departments & Units Services & Centers Institutes & Centers Scott Franzblau DirectorITR Glen Schumock Director Ctr. Pharmco- economics Res. Mary Moody Director Drug. Info. Ctr.

University of Illinois at Chicago College of Pharmacy UIC Degree Programs Doctor of Pharmacy (Pharm. D.) Joint Programs  Pharm.D./Ph.D.  Pharm.D./M.B.A.  M.D./Ph.D. Doctor of Philosophy  Ph.D. in Pharmacy (Administration)  Ph.D. in Biopharmaceutical Sciences  Ph.D. in Pharmacognosy  Ph.D. in Medicinal Chemistry Master of Science  M.S. in Forensic Science

University of Illinois at Chicago College of Pharmacy UIC Infectious Diseases (e.g., HIV/AIDS) Cardiology Transplantation Renal Ophthalmic Central Nervous System/Epilepsy Pediatrics Pharmacoeconomics and Outcomes Research Clinical Use of Natural Products Oncology Others Pharmacy Practice (No Graduate Program)

University of Illinois at Chicago College of Pharmacy UIC Patient Outcomes Research Health Care Policy Comparative Health Care Systems Consumer Behavior Consumer Medication Use Safety Pharmacoeconomics and Management Pharmacists and Pharmacy Services Professional Educational Research and Instructional Methodologies Ph.D. in Pharmacy Administration

University of Illinois at Chicago College of Pharmacy UIC Drug Delivery (Pharmaceutics) Pharmacokinetics (Drug Disposition) Pharmacodynamics (Drug Action) Molecular target discovery Pharmacogenomics (Genetics of individualized drug response; targeted drug action) Toxicology/Pharmacogenomics Forensic Science (Unique nationally recognized program) Ph.D. in Biopharmaceutical Sciences

University of Illinois at Chicago College of Pharmacy UIC Biopharmaceutical Sciences

University of Illinois at Chicago College of Pharmacy UIC Ph. D. in Medicinal Chemistry or Pharmacognosy Synthetic chemistry (neurodegenerative and oncologic diseases) Computational Approaches to Drug Design Chemical Toxicology and Biological Mechanisms Synthetic Development of Enzyme Inhibitors and Low Molecular Weight Catalysts Natural Product Structure Elucidation Cancer Chemoprevention / Dietary Antioxidants Dietary Supplements for Women’s Health Method Development for Analysis of Botanicals Analytical Support (MS, NMR, etc)

University of Illinois at Chicago College of Pharmacy UIC MDCH-PCOG

University of Illinois at Chicago College of Pharmacy UIC M.S. in Forensic Science Criminalistics Forensic toxicology

University of Illinois at Chicago College of Pharmacy UIC Actively Managed or Marketed Inventions Over 70 active inventions reside in the portfolio in the areas of:  Alzheimer’s Disease  Anti-Infectives  Blood Substitutes  Cancer  Avoiding Drug Confusion Almost half have been exclusively licensed  Drug Delivery  Menopause  Natural Products  Pain  Research Tools (e.g., vectors, cell lines)

University of Illinois at Chicago College of Pharmacy UIC Laboratory Facilities

University of Illinois at Chicago College of Pharmacy UIC Laboratory Facilities (Cont.)