Healthy Mind, Healthy Sight.. u Dr. Guy Eakin, BrightFocus Foundation u Dr. Elia Duh, Johns Hopkins University u Dr. Seth Margolis, Johns Hopkins University.

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Presentation transcript:

Healthy Mind, Healthy Sight.

u Dr. Guy Eakin, BrightFocus Foundation u Dr. Elia Duh, Johns Hopkins University u Dr. Seth Margolis, Johns Hopkins University Healthy Mind, Healthy Sight.

BrightFocus Foundation  A Non-Profit Organization  Based in Clarksburg, Maryland  Supporting Research and Education to Save Mind and Sight

One in 16 Americans, age 40 and above, has Alzheimer’s disease, macular degeneration, or glaucoma. The Need for Cures is Great

Support Innovative, Cutting-Edge Research  BrightFocus has awarded more than 1,000 grants totaling $130 million. More than $26 million awarded in last four years. Our Research Mission

Providing the Public with Information:  Risk Factors  Early Detection /Diagnosis  Current Treatments  Coping Strategies for Patients and Caregivers Public Education

Glaucoma and Age-Related Macular Degeneration Elia Duh, M.D. Wilmer Eye Institute Johns Hopkins School of Medicine October 30, 2013

Glaucoma and Age-related Macular Degeneration (AMD) u Two of the most common causes of blindness in the United States u Risk factors: – AGE: especially over the age of 60 – Family history – Race

Glaucoma u Glaucoma: – Fluid builds up in the eye, so that the eye pressure rises – This higher eye pressure can damage the optic nerve over time

u Symptoms u Treatment u Research to improve treatments Glaucoma

Age-Related Macular Degeneration (AMD) u AMD: – Eye condition among people age 50 or older – It gradually damages (and even destroys) the macula u Dry form of AMD u Wet form of AMD

Age-Related Macular Degeneration (AMD) u Symptoms u Treatments u Research to improve treatments for AMD

Alzheimer’s Disease Dr. Seth Margolis Johns Hopkins University Department of Biological Chemistry Johns Hopkins School of Medicine October 30, 2013

Neurons Synapses Molecules Behavior Circuits

(Years) Genetic mutation and Risk factors Misfolding and aggregation of A  and tau followed by plaques and tangles Inflammatory Cell damage Preventative Modifying Symptomatic Cell death Clinical diagnosis Abnormal Normal Amyloid Neuron Injury Memory Dementia Mild

Daniel Colon-Ramos Karl Deisseroth

Spine Abnormalities are a Hallmark of Cognitive Disorders Reviewed in Ramakers et al. 2002, TINS UnaffectedAffected Non-syndromic MR Down’s Syndrome Rett Syndrome Fragile X syndrome Phenylketonuria Angelman Syndrome Alzheimer’s disease

Spine density Age Wenbiao Gan Dendritic Spine Density Changes with Development

anti-N-E5 anti-EphB2 Braak Embryonic

Genetic Cross Between Alzheimer Mice Models and Ephexin5 Knockout Mice X FemaleMale Electrophysiological properties: Dendritic spine morphology: Learning and memory: Alzheimer Mice Ephexin5 - /Ephexin5 - Ephexin5 - /Ephexin5 + Alzheimer’s

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