HORIZON 2020 The EU Framework Programme for Research and Innovation 2014-2020 Presentation to NUI Galway 10 September 2013 Kay Duggan-Walls, Health Research Board National Contact Point for Horizon 2020 Health

Proposal for H2020 Legislative proposal from Commission was announced 30 November 2011 Part of a drive to create new jobs and growth in Europe

What is Horizon 2020? Commission proposal for a €80 billion research and innovation funding programme (2014-2020) A core part of Europe 2020, Innovation Union & European Research Area: Responding to the economic crisis to invest in future jobs and growth Addressing people’s concerns about their livelihoods, safety and environment Strengthening the EU’s global position in research, innovation and technology

Horizon 2020 – What’s New A single programme bringing together three separate programmes/initiatives* Coupling research to innovation – from research to retail, all forms of innovation Focus on societal challenges facing EU society, e.g. health, clean energy and transport Simplified access, for all companies, universities, institutes in all EU countries and beyond *The 7th Research Framework Programme (FP7), innovation aspects of Competitiveness and Innovation Framework Programme (CIP), EU contribution to the European Institute of Innovation and Technology (EIT)

Three Priorities Excellent Science Industrial leadership Societal challenges ERC – frontier research by the best individual teams Future and emerging technologies – Collaborative research to open new fields of innovation Marie Curie actions – Opportunities for training and career development Research infrastructures ensuring access to world class facilities

Priority 1. Excellent science €25bn Why: World class science is the foundation of tomorrow’s technologies, jobs and well-being Europe needs to develop, attract and retain research talent Researchers need access to the best infrastructures European Research Council Frontier research by the best individual teams €13,263 Future and Emerging Technologies Collaborative research to open new fields of innovation €3,100 Marie Curie actions Opportunities for training and career development €5,752 Research infrastructures including e-infrastructures Ensuring access to world class facilities €2,478

Priority 2. Industrial leadership €18bn Why: Strategic investments in key technologies (e.g. advanced manufacturing, micro-electronics) innovation across existing and emerging sectors. Europe needs to attract more private investment in research and innovation Europe needs more innovative SMEs to create growth and jobs Leadership in enabling and industrial technologies (ICT, nanotechnologies, materials, biotechnology, manufacturing space) €13,781 Access to risk finance Leverage private finance and venture capital for research and innovation €3,538 Innovation in SMEs Fostering all forms of innovation in all types of SMEs €619

Priority 3. Societal challenges €32bn Why: Concerns of citizens and society/EU policy objectives (climate, environment, energy, transport etc.) cannot be achieved without innovation Breakthrough solutions come from multi-disciplinary collaborations, including social sciences & humanities Promising solutions need to be tested, demonstrated and scaled up Health, demographic change and wellbeing €8,033 Food security, sustainable agriculture, marine and maritime research & the bio economy €4,152 Secure, clean and efficient energy €5,782 Smart, green and integrated transport €6,802 Climate action, resource efficiency and raw materials €3,160 Inclusive, innovative and secure societies €3,819

Horizon 2020

Horizon 2020 and partnering: an overview Public private partnerships Through Joint Technology Initiatives (JTIs) or other formal structures (Art 187) Through contractual agreements, which provide input for work programmes Only when criteria met, e.g. clear commitment from private partners Public public partnerships: Through ‘ERA-Nets’ for topping up individual calls/actions (replacing current ERA-Net, ERA-Net Plus, Inco-Net, Inno-net) Through participation in joint programmes between Member States (Art. 185) Supporting agendas of Joint Programming Initiatives when in line with Horizon 2020 Only when criteria met, e.g. financial commitments of participating countries European Innovation Partnerships Not funding instruments, but for coordination with broader policies and programmes

FP7 Cooperation themes → HORIZON2020 challenges Health (€6.1b) Food, agriculture, fisheries and biotechnology Information and communication technologies Nanosciences, nanotechnologies, materials and new production technologies Energy Environment (including climate change) Transport (including aeronautics) Socio-economic sciences and the humanities Security Space The Health, Demographic Change and Well-being Challenge (€7bn over 7 yrs) The Food Security and Bio-based Economy Challenge The Secure, Clean and Efficient Energy Challenge The Smart, Green and Integrated Transport challenge The Resource Efficiency and Climate Challenge The Inclusive, Innovative and Secure Societies Challenge

The Health, Demographic Change and Well-being Challenge Basic research through translation of knowledge, to large trials and demonstration actions Broader scope than FP7 More ICT aspects Public procurement for new products, services, scalable solutions (interoperable and supported by defined standards and/or common guidelines) – haven’t had this before in Health

Specific activities proposed 1.1. Understanding health, wellbeing and disease 1.1.1. Understanding the determinants of health, improving health promotion and disease prevention 1.1.2. Understanding disease 1.1.3. Improving surveillance and preparedness 1.2. Preventing disease 1.2.1. Developing effective  prevention and screening programmes and improving the assessment of disease susceptibility 1.2.2. Improving diagnosis and prognosis 1.2.3. Developing better preventive and therapeutic vaccines 1.3. Treating and managing disease 1.3.1. Treating disease, including developing regenerative medicine 1.3.2. Transferring knowledge to clinical practice and scalable innovation actions

Specific Activities proposed 1.4. Active ageing and self-management of health 1.4.1. Active ageing, independent and assisted living 1.4.2. Individual awareness and empowerment for self-management of health 1.5. Methods and data 1.5.1. Improving health information and better use of health data 1.5.2. Improving scientific tools and methods to support policy making and regulatory needs 1.5.3. Using in-silico medicine for improving disease management and prediction 1.6. Health care provision and integrated care 1.6.1. Promoting integrated care 1.6.2. Optimising the efficiency and effectiveness of healthcare provision and reducing inequalities by evidence based decision making and dissemination of best practice, and innovative technologies and approaches

Proposed Work Programme Cycle 2014 2015 2016 2017 2018 2019 2020   Strategic Programme Work Programme 1 (plus tentative information for 2016) Work Programme 2 (plus tentative information for 2018) Work Programme 3 (plus tentative information for 2020) Work Programme 4 First calls mid-December

Strategic Programme for the 2014-2016 Work Programme

Horizon 2020 Work Programme Horizon 2020 is different Multidisciplinary approach Strong challenge based approach – allowing applicants freedom to come up with innovative solutions Simplified list of possible type of action (research and innovation 100%; innovation actions – 70%) Less prescription, strong emphasis on expected impact Broader topics Cross-cutting issues mainstreamed (e.g. social science, gender)

Personalised Health and Care Choice to focus on personalised health and care – informed by ageing of the European population Increasing communicable and non-communicable disease burden Fall out from economic crisis Aims to create opportunities for real breakthrough research and radical innovation Supporting translational of findings into clinic and other healthcare settings to improve health outcomes, reduce inequalities and promote active and healthy ageing

Rational for 1st Work Programme Demographic changes Chronic diseases Sustainability of health and care systems – cost of inaction Drug development pipeline Infectious disease – in terms of global development, resurgence, pandemic threat Big data

Work programme Topics Structure reflects the challenge based approach Specific Challenge – sets the context, the problem to be addressed, why intervention is necessary Scope – delineates the problem, specifies the focus and the boundaries of the potential action BUT without overtly describing specific approaches Expected Impact – describe the key elements of what is expected to be achieved in relation to the specific challenge

Work Programme Summary Understanding health, ageing and disease – 2 topics Effective health promotion, disease prevention, preparedness and screening – 6 topics Improving diagnostics – 3 topics Innovative treatments and technologies – 6 topics Advancing active and healthy ageing – 3 topics Integrated, sustainable, citizen-centred care – 7 topics Improving health information, data exploitation and providing an evidence-base for health policies and regulation – 5 topics

Work Programme Societal challenge ‘Health demographic change and wellbeing’ 2014 & 2015, 32 topics the ‘personalised health and care’ focus area call 10 topics in the ‘co-ordination activities’ call

Work Programme Topics PCH 1 – 2014 Understanding health, ageing and disease: determinants, risk factors and pathways PCH 2 – 2015 Understanding health, ageing and disease: systems medicine PCH 3 – 2015 Health promotion and disease prevention: improved inter-sector cooperation for environment and health based interventions PHC 4 – 2015 Health promotion and disease prevention: translating ‘omics’ into stratified approaches

Work Programme Topics cont. PHC 5 – 2014 Evaluating existing screening and prevention programmes PHC 6 – 2014 Improving the control of infectious epidemics and foodborne outbreaks through rapid identification of pathogens PHC 7 – 2014 Vaccine development for poverty-related and neglected infectious diseases: Tuberculosis PHC 8 – 2015 Vaccine development for poverty-related and neglected infectious diseases – HIV/AIDS PHC 9 – 2014 Development of new diagnostic tools and technologies: in vitro devices, assays and platforms PHC 10 – 2015 Development of new diagnostic tools and technologies: in vivo medical imaging technologies

Work Programme cont. PHC 11 – 2014 and 2015 Clinical validation of biomarkers PHC 12 – 2014 New therapies for chronic and non-communicable diseases PHC 13 – 2015 New therapies for rare diseases PHC 14 – 2014/15 Clinical research on regenerative medicine PHC 15 – 2015 Tools and technologies for advanced therapies PHC 16 – 2014 Comparing the effectiveness of existing healthcare interventions in the elderly

Work Programme cont. PHC 17 -2015 Establishing effectiveness of health care interventions in the paediatric population PHC 18 – 2014 Advancing active and healthy ageing with ICT: Service robotics within assisted living environments; and ICT solutions for independent living with cognitive impairment PHC 19 – 2015 Advancing active and healthy ageing with ICT: Early risk detection and intervention PHC 20 – 2015 Promoting mental wellbeing: in the ageing population

Work Programme cont. PHC 21 – 2014 Developing and comparing new models for safe and efficient, prevention orientated, health and care systems PHC 22 – 2015 Piloting personalised medicine in health and care systems PHC 23 – 2015 Advanced ICT systems and services for integrated care PHC 24 – 2014 Self-management of health and disease: citizen engagement and mHealth PHC 25 – 2015 Self-management of health and disease: decisional support systems and patient empowerment supported by ICT PHC 26 – 2015 Public procurement of innovative eHealth services

Work Programme cont. PHC 27 201? eHealth Sectoral Prize PHC 28 – 2015 Digital representation of health data to improve diseases’ diagnosis and treatment PHC 29 – 2014 Foresight for health policy development and regulation PHC 30 – 2014 Advancing bioinformatics to meet biomedical and clinical needs PHC 31 – 2015 New approaches to improve predictive human safety testing PHC 32 – 2014 eHealth interoperability

Co-ordination activities HCO 1 - 2014 Innovative Partnership: Support for the European Innovative Partnership on Active and Health ageing HCO 2 – 2014 Joint Programming: Coordination Action for the Joint Programming Initiative (JPI) ‘More Years, Better Lives – the Challenges and Opportunities of Demographic Change’ HCO 3 – 201? Support for the European Reference Networks: Efficient network modelling and validation HCO 4 – 2014 Support for international infectious disease preparedness research HCO 5 – 201? Global Alliance for Chronic Diseases: Prevention and treatment type 2 diabetes

ERA-NETs HCO 6 – 2014 ERA-NET Establishing synergies between the Joint Programming on Neurodegenerative Disease Research and Horizon 2020 HCO 7 – 2014 ERA-NET: Cancer research programmes and activities HCO 8 – 2014 ERA-NET: Brain related diseases research programmes and activities HCO 9 – 2014 ERA-NET: Systems medicine for clinical needs research programme and activities HCO 10 – 201? ERA-NET: Rare disease research implementing IRDiRC objectives

Budget Horizon 2020 - €70bn over 7 years SC1 (health) - €7bn over 7 years first 2 years – only €1bn across 32 topics 15% of budget ICT topics 1/3 of funding will be provided for ERA-NETs

Horizon 2020 is different Web portal with one entrance for the Programme Counting on MS to explain to researchers – need to look at entirety of the programme not just SC1 ERC – increase in budget to €15.6bn- 20% ~ life sciences – may be first port of call Encouraged to look at other schemes

Timeline Commission published Horizon 2020 package on 30 Nov 2011 Council agreed ‘Partial General approaches’ on Regulation in May; on the Rules in October and the Specific Programme in December 2012 The ITRE Committee of Parliament proposed amendments in November 2012 ‘Adoption of Horizon 2020 legislative acts expected at end 2013 First calls: expected mid-December Structure H2020 programme committees to be agreed Health Advisory Groups to be established Nominations for NCPs have been sought Structure h2020 programme committes to be agreed Health Advisory Groups to be established Nominations for NCPs

Ireland’s Results FP7 Health 490 participations 28 successful coordinators 117 successful partners 15.5% funding ~ 4 clinical trials projects Total funding in FP7 Health - €77.68m Ireland target €600 million ~ €502 million Health target 1.25% - exceeded 1.7%

Ireland’s FP7 Health Participation 2007-2013 €77.68m   FP7 Call 1 2007A FP7 Call 2 2007B FP7 Call 3 2009 FP7 Call 4 2010 FP7 Call 5 2011 FP7 Call 6 2012 FP7 Call 7 2013 Second Stage Number of individual participations - Partners - Coordinators 74 71 3 93 82 11 64 7 62 49 13 58 48 10 44 14 63 Successful coordinators 4 1 10‡ Successful partners¥ 17 15 9 20 21 22 Project Success rate 24% TS*50%$ TS* 80%$ TS* 40.9% Innov1# 42.5%, Innov2& 60% Innov1# 43% Innov2& 0% EU success rate 17% 20% TS*42%$ TS* 41%$ Innov1# 39%, Innov2& 42% Innov1# 35% Innov2& 32% Total Budget available €637m €549m €591m €628m €662m €657.6m €819.3m Total Funding to Ireland €6m €5.88m €4.4m €17.4 €13.6 €18.6 €11.8 ** TS = Two stage , $ at second stage, # Innovation 1 call, & Innovation 2 call (SME focused), ¥ Some projects have multiple Irish Partners, ‡ Highest success rate for coordinators in EU (71.4%)

Health NCPs for Ireland Kay Duggan-Walls Health Research Board kdugganwalls@hrb.ie Ciaran Duffy Enterprise Ireland Ciaran.duffy@enterprise-ireland.com Patricia Clarke (National Delegate) pclarke@hrb.ie Meet regularly – meetings/teleconference/email

For further information contact Kay Duggan-Walls kdugganwalls@hrb.ie tel (01) 2345 187