Main slide Digitalis leaves: Jaborandi leaves. Medical plant names.

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Main slide Digitalis leaves: Jaborandi leaves. Medical plant names. Plant history. Description of crude drug. Origin and constituents. Pharmacological activity and drugs. Herbal-drug interactions. Jaborandi leaves. Description. Pharmacological effects and therapeutic indications. Drugs.

Rough and hairy leaves Purple flowers Main slide

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Digitalis lanata Main slide

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D.lanata Main slide

Digitalis leaves :Foxglove leaves: Folia Digitalii Digitalis purpurea Digitalis lanata Digitalis dubia Digitalis ferruginea Digitalis grandiflora Family : Scrophulariaceae Main slide

Digitalis is an example of a cardio-active or cardio tonic drug, in other words a steroid which has powerful action on the cardiac muscle in animals, and has been used in the treatment of heart conditions ever since its discovery in 1775. The discovery of digitalis is accredited to the Scottish doctor William Withering . Main slide

Description Biennial herbaceous plant . Odor : distinct. Taste : bitter . D.purpurea : has hairy leaves with purple flowers. D.lanata : has very hairy leaves with whitish pink flowers . Main slide

Origin Southern and Central regions of Europe Chemical constituents Glycosides: cardiac (steroidal) group: Digoxin . Digitoxin. Gitoxin (3 molecule of digitoxose + aglycone part ) Main slide

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Uses: Congestive heart failure. Arrhythmia . Drugs Digoxin – zori : (Teva) Tablets 0.25mg Lanoxin : (Wellcome) Tablets: 0.25mg 0.0125mg,0.00625mg b) Elixir ped. : 0.05mg c) Amp.: o.5mg Main slide

Drug interaction Acetaminophen, aspirin, digoxin    Decreased/delayed drug absorption Main slide

Red flower Oval with entire margin Main slide

Jaborandi leaves: Jaborandi leaflets: Folia Jaborandi Pilocarpus jaborandi Pilocarpus pinnatifolius Family: Rutaceae Main slide

Description: Perennial mild trees (4-5m) height with red flowers . The leaves (leaflets) are oval with entire margin. Odor :characteristic Taste :Bitter ,pungent and aromatic. Main slide

Chemical constituents Origin Brazil and Paraguay. Chemical constituents 1-Alkaloids (0.5%-1%) imidazole group-Pilocarpine. 2- volatile oil 0.5% Main slide

The pharmacological effects and uses of pilocarpine - Parasympathomimetic agent. -Stimulates directly muscarinic receptors in the eyes which causes pupil constriction (myosis). -Increase body secretions . Uses: 1- Antidote in case of poisoning from atropine (parasympatholytic agent). 2- Treatment of Glaucoma. 3- treatment of xerostomia. Main slide

DRUGS Glaucocarpine ® Drops Ophthalmic solution Taro 1%-4% Glaucoma Mi-Pilo ® Ophthalmic solution Fischer + lacrimol 2,4% Control intra ocular pressure Pilocarpine HCl ® Vitamed Timpilo ® MSD +timolol Decrease (IOP) Salagen ® Tab Mega-pharm 5mg Radiatin induced xerostomia Main slide

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