BASI MOLECOLARI DELLAZIONE DEL FARMACO BIOTECNOLOGIE FARMACOLOGICHE LEZIONE 12 In vivo imaging CORSO DI LAUREA SPECIALISTICA IN BIOTECNOLOGIE DEL FARMACO.

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Presentation transcript:

BASI MOLECOLARI DELLAZIONE DEL FARMACO BIOTECNOLOGIE FARMACOLOGICHE LEZIONE 12 In vivo imaging CORSO DI LAUREA SPECIALISTICA IN BIOTECNOLOGIE DEL FARMACO Adriana Maggi

Target identification and validation with reporter mice Maggi and Ciana NRDD, 2005

MOLECULAR IMAGING 2007 THE AVAILABLE TOOLS 2/06

MULTI-MODALITY MOLECULAR IMAGING IN LIVING SMALL ANIMALS Functional Magnetic Nuclear Resonance Optical imaging Bioluminescence Ultrasound MicroPET Positron emission tomography Nuclear imaging Micro SPECT single-photon emission computerized tomography 2/06 Fluorescence

a 2/06 MOLECULAR IMAGING TO REVISIT ANIMAL EXPERIMENTATION IN THE RESPECT OF ANIMAL SUFFERING

PARTICULARLY, IN PHARMACOLOGICAL RESEARCH! ONE PICTURE IS WORTH TEN THOUSAND WORDS (Frederic Barnhard 1927) 2/06

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