Long/Short Pulse Laser Platform Our Solutions Long/Short Pulse Laser Platform Alexandrite 755 nm Long Pulse, up to 16 mm spot size and 2Hz of repetition rate Nd:YAG frequency doubled 532 nm Long Pulse, up to 4 mm spot size and 1Hz of repetition rate Nd:YAG 1064 nm Long Pulse, up to 12 mm spot size and 2Hz of repetition rate Nd:YAG 1064 nm Short Pulse, Up to 8 mm spot size and 7Hz of repetition rate Nd:YAG 1320 nm Long Pulse, Up to 8 mm spot size and 5 Hz of repetition rate IPL source with cut-off filters at 400, 550, 570, 590, 625, 650 nm. Fluence up to 35J/cm2 and 0.5 Hz of repetition rate Combined System, top performances, best return of investment

Vascular lesions removal Pigmented lesions removal Indications Hair Removal Vascular lesions removal Pigmented lesions removal Benign skin solid lesions Scar revision Skin sun damage

SELECTIVE PHOTOTHERMOLYSIS Indications SELECTIVE PHOTOTHERMOLYSIS (RR Anderson, JA Parrish, 1983)

Wavelength Fluence Pulse Width: ≤ TRT Selective Photothermolysis Selective aggression of the target without damage of adjacent tissues Parameters: Wavelength Fluence Pulse Width: ≤ TRT

Selective Photothermolysis Absorption The green 532 nm and the infrared 1064 nm lights are absorbed by the hemoglobin which is the targeted chromophore when treating dermal blood vessels. 532 and 1064 nm are optimal wavelengths for treating superficial micro vessels. 755 nm for hair removal up to Skin Type IV, 1064 nm also for darker skin 1320 nm, due to optimal water absorption is ideal for dermal remodeling The epidermal melanin absorption has to been taken into consideration to avoid side effects.

Approx. wavelenghts penetration in the skin Selective Photothermolysis Approx. wavelenghts penetration in the skin Penetration Longer wavelengths as preferable for deeper or larger vessels, because of their greater penetration into tissue and because The relative low melanin absorption may allow more safe heating of the full thickness of the vessel with less risks of epidermal ipo-pigmentation. For small teleangiectasia - such as those occurring commonly on the face and for PWS, lasers emitting wavelengths at or near 532nm are highly suitable, For leg veins treatments the 1064 nm wavelength of is preferable.

Thermal relaxation time for vessels of various diameters Selective Photothermolysis Laser pulse duration – TRT of targets Exposure times for blood vessels should be shorter than their thermal relaxation times Complete heating is achieved without risks of thermal damage of the surrounding tissues (Selective Photothermolysis). Exposure times range from 1 to 10 milliseconds for port wine stains and about 5 to 70 milliseconds for telangiectasia. The power output of the laser must be high enough to permit adequate energy density for vessel coagulation within this time (Energy = Power x Time). Thermal relaxation time for vessels of various diameters Diameter (µm) 30 50 70 100 150 200 250 300 350 400 TRT (ms) 0.4 1.0 2.0 4.2 9.4 16.7 26.0 37.5 51.0 66.7

“milliseconds laser” effect on blood vessels 700 800

Adjustable pulse duration spares normal capillaries, avoiding purpura. “milliseconds laser” effect on blood vessels Adjustable pulse duration spares normal capillaries, avoiding purpura. Purpura after pulsed dye laser Tx

Some Clinical Results

Facial telangiectasia SYSTEM: LASER 532 nm SKIN TYPE 2 AREA: FACE EV. FLUENCE: 23 J/Cm2 FREQUENCY: 2 Hz SESSIONS: 3 FOLLOW UP: 2 months

Facial telangiectasia SYSTEM: 532 nm LASER SKIN TYPE 2 AREA: FACE EV. FLUENCE: 14 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 2 FOLLOW UP: 6 months

Spider angioma SYSTEM: 532 nm Laser SKIN TYPE 3 AREA: FACE SPOT SIZE: 2 mm EV. FLUENCE: 23 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 2 FOLLOW UP: 6 months

Spider angioma SYSTEM: Long Pulse 532 nm SKIN TYPE 3 AREA: Lt upper lid EV. FLUENCE: 16 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 1 FOLLOW UP: 4 Weeks

Spider angioma SYSTEM: 532 nm LASER SKIN TYPE 2 AREA: Nose EV. FLUENCE: 15 J/Cm2 FREQUENCY: 2 Hz SESSIONS: 2 FOLLOW UP: 2 months

Angioma - PWS SYSTEM: Long Pulse 532 nm SKIN TYPE 3 AREA: BACK SPOT SIZE: 2 mm EV. FLUENCE: 13 J/Cm2 @ 532 nm FREQUENCY: 1 Hz SESSIONS: 1 (test) FOLLOW UP: 3 weeks

Angioma - PWS SYSTEM: Long Pulse 532 nm SKIN TYPE 5 AREA: cheek and neck SPOT SIZE: 4 mm EV. FLUENCE: 13 J/Cm2 @ 532 nm FREQUENCY: 1 Hz SESSIONS: 5 FOLLOW UP: 3 months

Hemangioma SYSTEM: Nd:YAG LASER 1064 nm SKIN TYPE 2 AREA: cheek and neck SPOT SIZE: 6 mm EV. FLUENCE: 40 J/Cm2 @ 1064 nm (test) FREQUENCY: 1 Hz SESSIONS: 1 FOLLOW UP: 1 month

Leg telangiectasia SYSTEM: 1064 nm LASER SKIN TYPE 3 EV. FLUENCE: 140 J/Cm2 @ 1064 nm FREQUENCY: 1 Hz SESSIONS: 3 FOLLOW UP: 6 months

Leg telangiectasia SYSTEM: Light C 532 and 1064 nm LASER SKIN TYPE 2 SPOT SIZE: 4 mm EV. FLUENCE: 130 J/Cm2 @ 1064 nm FREQUENCY: 1 Hz SESSIONS: 2 FOLLOW UP: 6 months

Scars SYSTEM: LASER 532 nm SKIN TYPE: 4 AREA: FACE EV. FLUENCE: 10 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 3 FOLLOW UP: 4 months

Keratosis SYSTEM: 532 nm Laser SKIN TYPE 3 EV. FLUENCE: 40 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 1 FOLLOW UP: 6 Weeks

Epidermal nevus SYSTEM: 532 nm Laser SKIN TYPE 2 AREA: Neck EV. FLUENCE: 30 J/Cm2 FREQUENCY: 6 Hz SESSIONS: 1 FOLLOW UP: 8 Weeks

Hair removal SYSTEM: Long Pulse 1064 nm SKIN TYPE: 3 AREA: BIKINI LINE SPOT SIZE: 10 mm EV. FLUENCE: 45 J/Cm2 FREQUENCY: 2 Hz SESSIONS: 5 FOLLOW UP: 6 months

Hair removal SYSTEM: Long Pulse 755 nm SKIN TYPE 3 AREA: AXILLA SPOT SIZE: 12 mm EV. FLUENCE: 25 J/Cm2 FREQUENCY: 1 Hz SESSIONS: 4 FOLLOW UP: 6 months

Hair removal SYSTEM: Long Pulse 1064 nm SKIN TYPE 3 AREA: Chest SPOT SIZE: 10 mm EV. FLUENCE: 60 J/Cm2 FREQUENCY: 1.5 Hz SESSIONS: 5 FOLLOW UP: 6 months

Hair removal Female axilla, skin type II Treatment parameters with IPL Handpiece: 625-1200 nm Average Fluence: 20 J/Cm2 Pulse mode: Burst 2 Pulse width: 20 ms Pulse pause: 20 ms N. Of treatments: 4

Skin rejuvenation SYSTEM: Short Pulse 1064 nm SKIN TYPE 5 AREA: FACE SPOT SIZE: 6 mm EV. FLUENCE: 16 J/Cm2 FREQUENCY: 7 Hz SESSIONS: 4 FOLLOW UP: 6 months

Skin rejuvenation SYSTEM: Long Pulse 1320 nm SKIN TYPE 3 AREA: FACE SPOT SIZE: 6 mm EV. FLUENCE: 15 J/Cm2 FREQUENCY: 2 Hz SESSIONS: 5 FOLLOW UP: 3 months

Skin rejuvenation Female facial sundamage, skin type III Treatment parameters with IPL Handpiece: 590-1200 nm Average Fluence: 18 J/Cm2 N. Of treatments: 3

Benign pigmented lesions SYSTEM: IPL 550-950 nm filter SKIN TYPE 2 AREA: forehead SPOT SIZE: 2.5x1.3 cm EV. FLUENCE: 18 J/Cm2 SESSIONS: 2 FOLLOW UP: 6 months

Active acne SYSTEM: IPL 400-1200 nm filter SKIN TYPE 2 AREA: forehead SPOT SIZE: 4.8x1.3 cm EV. FLUENCE: 7 J/Cm2 FREQUENCY: 0.5 Hz SESSIONS: 5 FOLLOW UP: 2 months

Active acne SYSTEM: IPL 400-1200 nm filter SKIN TYPE 2 AREA: forehead SPOT SIZE: 4.8x1.3 cm EV. FLUENCE: 7 J/Cm2 FREQUENCY: 0.5 Hz SESSIONS: 5 FOLLOW UP: 2 months

One System with four different wavelengths The Clinic in a System dermatology platform One System with four different wavelengths Long Pulse Alexandrite 755 nm for HAIR REMOVAL Long pulse Nd:YAG 1320 nm for SKIN REJUVENATION Long Pulse Nd:YAG frequency doubled 1064 + 532 nm for VASCULAR LESIONS and HAIR REMOVAL in dark skin IPL Extension for MAXIMUM FLEXIBILITY of use

Power level at the top of the category Four wavelengths. One solution!

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