NILOFAR RAHMAN, MD AMIT KUMAR, MD
DEFINITION A SVT with uncoordinated atrial activation with constant deterioration of atrial mechanical function On EKGs it is defined by replacement of consistent P waves with rapid oscillations that vary in size, shape and timing ass. With an irregular RVR when AV conduction is intact.
CLASSIFICATION PAROXYSMAL: Self terminates< 7 days, usu, within 24 hrs. PERSISTENT: > 7 days, terminate spontaneously or by cardioversion PERMANENT : > 1 YR, CV attempted or failed LONE : Without any structural heart disease
HTN: 1.4 fold increase risk CHD: when complicated by acute MI or heart failure CASS trial: RR was 1.98 in 7 yrs VALVULAR HEART DISEASE: MS, MR, TR: 70% RISK MS, MR: 52% ISOLATED MS: 29% HYPERTROPHIC CMP: CONGENITAL HEART DISEASE OTHERS: hyperthyroidism, PE, COPD, lupus myocarditis OSA: reduced reccurence with treatment
CLINICAL MANIFESTATIONS SYMPTOMATIC OR ASX EVEN IN SAME PT. PALPITATION/CP/DYSPNEA/FATIGUE/LIGHTHEADEDNESS/SYNCOPE EMBOLIC COMPLIC. OR HEART FAILURE POLYURIA: ANP ASS. RVR- CMP
H&P: EKG: verify AF CXR: lungs, vasculature and cardiac outline ECHO TTE: size and function of chambers, valvular heart diseases TEE: thrombi in left atrium TSH ADDITIONAL TESTING: EXERCISE TEST HOLTER/EVENT MONITOR
GENERAL PRINCIPLES OF TREATMENT RHYTHM CONTROL CONVERSION TO NSR MAINTAINENCE RATE CONTROL MEDICATION RADIOFREQUENCY ABLATION CHOOSING B/W RATE AND RHYTHM CONTROL PREVENTION OF SYSTEMIC EMBOLIZATION
RATE VS. RHYTHM CONTROL AFFIRM AND RACE TRIALS: 2 CONCLUSIONS- Embolic event occur in equal frequency lower incidence of primary end point with rate control strategy
RATE CONTROL Beta blockers Calcium channel blockers Digoxin GOALS: HR<80 bpm, 24 hr. Holter average <100 bpm, HR < 110 bpm in 6 min. walk Non pharmacologic method: radiofrequency ablation and pacemaker implantation
RHYTHM CONTROL PHARMACOLOGIC DIRECT CURRENT CARDIOVERSION Anticoagulation for 3-4 weeks before CV Anticoag for 1 month after CV usu done in hemodynamically unstable pts. success rate is 75-93%, inversely related to atrial size and duration
Maintenance of NSR: 20-30% maintain NSR > 1 yr. w/o antiarrythmics duration of <1 yr, atrial size < 4 cm. reversible causes Amiodarone is known to be most effective CTAF and AFFIRM trials Flecainide and propefenone in those without heart disease
RISK OF STROKE IS 3-5% WITHOUT ANTICOAGULATION CHADS2 SCORE SCORE OF 0: ASA SCORE 1-2: ASA/WARFARIN SCORE > 2: WARFARIN, INR GOAL 2-3
APPROVED IN 10/10 RE-LY TRIAL EVALUATED SAFETY OF 2 DOSES RESULTS: Rate of stroke was lesser High dose - more effective than warfarin Risk of bleeding was lesser in low dose All-cause mortality was reduced
DISADVANTAGES Twice dosing High cost Lack of an antidote Dose adjustment for those with CKD lack of long term safety data
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