Mammalian Liver tissue: X.

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Presentation transcript:

Mammalian Liver tissue: X

(note: no ATP required!)

Glycogenin: catalyzes glucose transfer from UDP-glucose (red) to tyr 194 (blue); Mn 2+ (green) required to stabilize UDP leaving group

Rabbit muscle Phosphorylase Kinase γ (catalytic) subunit active fragment complexed with ATP and a heptapeptide (RQMSFRL).

Phosphorylase kinase δ subunit (calmodulin)

As with glycogen phosphorylase: (a) phosphorylase kinase found in two isoforms in both muscle/liver tissues either active or inactive for glycogen breakdown (b) these isoforms differed by phosphorylation

Catalytic (C) subunit of mouse protein kinase A (PKA) complexed with ATP and a peptide inhibitor (Ser→Ala)

Regulatory (R) subunit of bovine protein kinase A (PKA) complexed with 2 cyclic-AMP molecules (activate C*R dissociation)

PEP