Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Christopher D. Lindsay, Christopher Green,

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Presentation transcript:

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Christopher D. Lindsay, Christopher Green, Mike Bird, James T. A. Jones, James R. Riches, Katherine K. McKee, Mark S. Sandford, Debra A. Wakefield, and Christopher M. Timperley R. Soc. Open Sci. Volume 2(1): January 28, 2015 ©2015 by Royal Society

Compounds of interest. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2: ©2015 by Royal Society

Relationship of structure to hTRPA1 activation. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2: ©2015 by Royal Society

hTRPA1 agonist potency correlates with irritancy to humans. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2: ©2015 by Royal Society

CR and CS react reversibly with N-acetyl-l-cysteine methyl ester in CDCl3. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2: ©2015 by Royal Society

Reactivity of BMNs to thiols. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2: ©2015 by Royal Society