picoSpin 45 & 80 Product Overview

Key Learning Fast Facts Front panel Rear panel Specifications Inside the box Capillary cartridge Inside the cartridge Cartridge, magnet, preamplifier Software Website resources

Fast Facts Worlds first miniature NMR spectrometer. The picoSpin 80 has the highest magnetic field strength (2 Tesla) and highest resolution (20 ppb) of all known bench- top NMR spectrometers on the market. picoSpin 45 and 80 are very similar and use common parts. picoSpin software is hosted on the spectrometer. The standard warranty period is 12 months from the date that the installation was accepted and signed off by the customer or 14 months from the date of shipment after the system ships from the factory or whichever comes first. picoSpin is the world first miniature NMR spectrometer. The picoSpin 45 NMR spectrometer is a complete 45 MHz pulsed Fourier-transform liquid-phase proton NMR spectrometer in a shoebox-sized package. To date, the picoSpin 80 has the highest magnetic field strength (2 Tesla) and highest resolution (20 ppb) of all known bench-top NMR spectrometers on the market. It provides an 82MHz resonance frequency for 1H detection and a capillary injection port, obviating the need for dedicated NMR tubes. Deuterated solvents are not required (although can be optionally used to avoid large protic solvent signals); field drift is compensated for automatically in software. Both the picoSpin 45 and 80 includes a capillary cartridge, a permanent magnet with temperature controller and shim system, radiofrequency transmitter and receiver, digital data acquisition and signal processing, a programmable pulse sequencer, and a web browser user interface. The picoSpin software system is hosted on the spectrometer and is ready to be used once the spectrometer is turned on and connected to any computer.

Fast Facts The picoSpin is an NMR (Nuclear Magnetic Resonance) product that was acquired by Thermo Fisher Scientific in 2012. The picoSpin 45 was introduced in 2010 and the picoSpin 80 in 2013. The picoSpin 45 and 80 is simple enough to be installed by customers, but customers can purchase Installation and Training. There is one (non-critical) moving part in the picoSpin 45 and picoSpin 80 NMR spectrometers. Validation service is currently not offered. The picoSpin is an NMR (Nuclear Magnetic Resonance) product that was acquired by Thermo Fisher Scientific in December of 2012. In 2010, picoSpin introduced the picoSpin 45, which offered the capabilities of larger spectrometers in a much more affordable, shoebox-sized unit. Headquartered in Boulder, Colorado, the picoSpin product line is part of the Molecular business unit within the Chemical Analysis Division (CAD). The picoSpin 80 was introduced in 2013. The picoSpin 45 and 80 is simple enough to be installed by customers, but customers can purchase a 2 hour Installation and familiarization package. It is important that customers follow the site-prep guide to install the system at least 4 hours prior to the arrival of the certified Thermo Fisher Scientific field service engineer.

picoSpin 45 and 80 Spectrometer Front Panel LCD Display Sample inlet port Replaceable Cartridge 5

picoSpin 45 and 80 Spectrometer Back Panel Cooling Fan ON/OFF Switch Power Connection +12 V: 110-240 VAC Cat-5 Ethernet Connection RS-232 Accessory Port 6

picoSpin 45 Product Features and Specs 45 MHz Pulsed FT NMR spectrometer Proton NMR of liquids; 19F version Better than 40 ppb typical resolution Single-shot SNR for water > 1000 10.5 lbs total weight; 5” x 8” x 10” Replaceable 400 µm ID capillary cartridge 20 µL sample volume Controlled by any web browser No cryogens, no compressed gas, etc. No special environment All solid-state, no moving parts Optional 12 month license to Mnova

picoSpin 80 Product Features and Specs 82 MHz Pulsed FT NMR spectrometer 1H instrument 20 ppb resolution 43 lbs total weight 17” x 14” x 10” Replaceable 400 µm ID capillary cartridge 40 µL sample volume No cryogens, no compressed gases needed No special environment Solid-state technology, no moving parts Ethernet interface; controlled by web browser Optional 12 month license to Mnova

Inside the Box picoSpin 45 & 80 Embedded web server No field replaceable parts Inside. Depot repair ONLY! Data converters, DSP Pulse sequencer Rx and Tx amplifiers Shim controller RF preamplifiers Permanent magnet Magnet temperature controller Fluid cartridge and sub-panel

Capillary Cartridge, Magnet, Pre-amplifier

Inside the Cartridge Tx/Rx Microcoil 0.4 mm ID quartz capillary PTFE transition Cartridge is customer replaceable

Capillary Cartridge picoSpin 45 & 80 picoSpin 45 picoSpin 80 Flange 20 µL sample volume 400 µm ID capillary 27 CM length 40 µL sample volume 400 µm ID capillary 32 CM length Flange picoSpin 45 Sub-panel picoSpin 80

Software picoSpin software is controlled by any web browser. Firefox browser is recommended.

Website Resources www.picospin.com www.thermoscientific.com PRODUCT SUPPORT WEBSITE (24/7) http://pghcr-pse-01/ (Thermo Scientific Employees) http://madisonsupport.thermofisher.com  (Approved Distributors)

Summary