BIPN 148 Lecture 16. Remembering Jennifer Anniston.

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Presentation transcript:

BIPN 148 Lecture 16

Remembering Jennifer Anniston

Activate Visual and Auditory Neurons

Stimulate Hippocampal Neurons

Visual Somatosensory Olfactory Auditory Perirhinal Cortex Entorhinal Cortex Dentate Gyrus CA3 CA1 Sensory Regions Of Cortex Perirhinal/ Entorhinal Cortex Hippocampal Formation Get info from cortex to hippocampus

Stimulate hippocampal synapses

Activate Spines

Potentiate Synapses

Activate CaMKII

Phosphorylate AMPA receptors

Phosphorylate GluR1on S831

Insert GluR1 at synapses

Unsilence synapses

Use Stargazin to traffic AMPA-R Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.

Induce gene expression

Use CaMKIV to induce gene expression

CRESRE zif268 C/EBP krox20 AMPAR HOMER BDNF NT-3 Arc CBP/CREB CaMKIV + ERK Elk-1 RSK2 Express new genes

New gene products or proteins Signal to nucleus New gene products or proteins Synaptic Potentiation Locally generated tag captures new gene product Synaptic tag NMDAR Send gene products to synapse

Remembering Jennifer Anniston Activate visual & auditory neurons Stimulate hippocampal neurons Change synaptic strength by inserting AMPA receptors Induce gene expression Stabilize change in synaptic strength Recall image with visual cue Don’t confuse with Angelina Jolie

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