CONVENTIONAL CANCER THERAPIES. Halsted’s Radical Mastectomy vs ‘Lumpectomy’

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Presentation transcript:

CONVENTIONAL CANCER THERAPIES

Halsted’s Radical Mastectomy vs ‘Lumpectomy’

3-D structure & schematic of p- glycoprotein

Examples: MethotrexateEg. Doxorubicin Eg. Cyclophosphoramide, Melphalan Eg. Vinblastine, paclitaxel

Newer Approaches to Cancer Therapy Incorporate Predictive Diagnosis Are Mechanism Based Designed for Selectivity

Figure 16.2 The Biology of Cancer (© Garland Science 2007)

Figure 16.4a The Biology of Cancer (© Garland Science 2007)

Figure 16.4b The Biology of Cancer (© Garland Science 2007)

Figure 16.5a The Biology of Cancer (© Garland Science 2007)

Figure 16.5b The Biology of Cancer (© Garland Science 2007)

Figure 16.5c The Biology of Cancer (© Garland Science 2007)

Figure 16.5d The Biology of Cancer (© Garland Science 2007)

Therapies Targeting nonTumor Cells

Table 13.3 The Biology of Cancer (© Garland Science 2007) Targeting the Angiogenic Switch

Tsp-1 Expression Induced by p53 Tsp-1 Expression Inhibited by Ras An Intrinsic Negative Regulator of Endothelial Cell Populations

VEGF-R Inhib. PDGF-R Inhib. Synergistic Inhibition of Angiogenesis by the Combination of a Pericyte Inhibitor and an Endothelial Cell Inhibitor

Figure 13.48a, b The Biology of Cancer (© Garland Science 2007) Radiation Can Have a Greater Effect on Cells of the Microvasculature Than on Tumor Cells Bone marrow origin of microvasculature cells

Figure The Biology of Cancer (© Garland Science 2007)

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