CNS Sequence CNS Histology March 9, 2009.

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Presentation transcript:

CNS Sequence CNS Histology March 9, 2009

Spinal cord Dorsal horns: Interneurons Ventral horns: Motor neurons Lateral horns: Sympathetic neurons Parasympathetic (S2-4) neurons DRG: Sensory (pseudounipolar) neurons Autonomic ganglia: Post ganglionic neurons with unmyelinated axons. Sympathetic: paravertebral ganglia Parasympathetic: In organs

66a Thoracic Spinal Cord Dorsal median sulcus Dorsal horn Dorsal nucleus of Clarke Lateral horn Ventral horn Ventral median fissure

(preganglionic sympathetic neurons of intermediolateral cell column) 66a Thoracic Spinal Cord Neurons in Lateral Horn Neurons in Ventral Horn (preganglionic sympathetic neurons of intermediolateral cell column) (motor neurons)

Thoracic cord dorsal horn: spinocerebellar neurons of Clarke’s nucleus (relay proprioceptive input up to cerebellar cortex: e.g. from muscle spindle  DRG  spinocerebellar neuron  cerebellum)

Thoracic cord: dorsal horn neurons (interneurons) short projections to other neurons at same level or nearby spinal level

#65-1N Spinal cord and DRG Dorsal horn Lateral horn Ventral horn Dorsal root ganglion (DRG)

65-1N Motor neurons, glial cells and neuropil

Dorsal root ganglion cells

Motor and Sensory Neurons (Multipolar) (Pseudounipolar)

Brain Cerebrum Cerebellum 3rd ventricle 4th ventricle Pons Sulcus (sulci) Gyrus (gyri) 3rd ventricle Cerebellum 4th ventricle Pons Medulla oblongata

Cerebrum and Cerebellum 77

#77 Cerebellum #76b Cerebrum C: Cortex of gray matter W: White matter C C C W W W

#77 Cerebellum Cortex White matter

#77 Cerebellum ML GL WM Purkinje neurons (cells)

#77a Cerebellar Cotex

#76 Cerebrum White matter Cortex of gray matter

#76 Cerebral cortex Ross and Pawlina, p.311

C C Cerebellum Cerebrum W W C: Cortex of gray matter W: White matter Purkinje cells (neurons) C C Pyramidal cells (neurons) W W

#NP004N Hippocampal region CA: Cornus ammonis ependymal cells of choroid plexus (cuboidal, eosinophilic: produce CSF) choroid plexus CA3 CA2 “typical” ependymal cells (columnar, lining cells) Hippocampus CA4 (hilus) Dentate gyrus CA1

3 layers of Hippocampal region (CA1-CA3) Polymorphic layer (nerve fibers, interneuron cell bodies) Pyramidal cell layer Molecular layer (dendrites of pyramidal cells) Pyramidal cells

3 layers of Dentate gyrus Molecular layer Molecular layer (dendrites of granule cells) Granule cell layer (neurons) Polymorphic layer Polymorphic layer (interneurons)

#74 Sympathetic ganglion cells #75 Parasympathetic ganglion cells Seminal vesicle

Sensory and Autonomic Neurons (DRG) (Parasympatheitc)