CHIC DNA Repository

MISSION –The CHIC DNA Repository, co-sponsored by the OFA and the AKC CHF, collects and stores canine DNA samples along with corresponding Genealogic and Phenotypic information to facilitate future research

CHIC DNA Repository OBJECTIVES –Facilitate more rapid research progress by expediting the sample collection process –Provide researchers with optimized family groups needed for research –Allow breeders to take advantage of future DNA based disease tests as they become available –Foster a team environment between breeders and the research community improving the likelihood of genetic discovery

CHIC DNA Repository AKC Delegates Meeting, Sept ’05 –Dr. Elaine Ostrander, AKC DNA Consultant, answers questions from the floor…”Besides money, what is the most important thing we can do to assist research efforts…” –Response: “PROVIDE SAMPLES”

CHIC DNA Repository Need for Education re: DNA –AKC DNA Program Imports Field Inspections Multiple Sired Litters Frequently Used Sire Parentage Verification / Stud Book Integrity –Versus DNA for Health Research Purposes

CHIC DNA Repository Blood versus Swab Solution –Blood Higher Yield Better Quality Works with all scientific applications Invasive High Cost Limited Participation –Swabs Low Cost Non Invasive Greater Participation Decreased Yield New Technology requires less quantity

CHIC DNA Repository Dual Solution…Blood or Swab –Blood University of Missouri, Dr. Gary Johnson’s Lab –Swabs University of California – Davis, Veterinary Genetics Lab, contacts: Dr. Mark Neff & Dr. Alison Ruhe

CHIC DNA Repository Pilot Program –6 Months –Golden Retriever Club of America –Sample, Genealogy, Health History collected on nearly 1,000 dogs –Mix of healthy / affected dogs Heart Murmurs, Hemangiosarcoma, Fibrosarcoma, Mast Cell Tumors, Hypothyroid, Cataracts, Hip & Elbow Dysplasia

CHIC DNA Repository 24 Months Later dogs 60 breeds 2 approved application for samples –MBT – Lens Luxation –GR – Mast Cell Tumor 4 clubs have facilitated transfer of samples from existing banks to CHIC (Miniature Bull Terriers, Otterhounds, Field Spaniels, Poodles) National Specialty DNA Clinics

Contact Info: –Eddie Dziuk, OFA, (573) –Erika Werne, AKC CHF, (888) Questions?