Lectures on Computational Biology HC Lee Computational Biology Lab Center for Complex Systems & Biophysics National Central University EFSS II National.

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Lectures on Computational Biology HC Lee Computational Biology Lab Center for Complex Systems & Biophysics National Central University EFSS II National DongHua University Hualien, 2002 July 1-5

What is Computational Biology? The use of computational techniques to model biological systems at various levels of complexity - atomic, metabolic, cellular and pathologic.

Central dogma for molecular biology DNA RNA Protein

Yeast alanyl transfer RNA DNA

Standard Genetic Code

Amino acid codes Name, 3-letter and single-letter codes Aspartic Acid Asp D Glutamic Acid Glu E Phenylanine Phe F Glycine Gly G Alanine Ala A Cystine Cys C Histidine His H Isoleucine Ile I Lysine Lys K LeucineLeu L Methionine Met M Asparagine Asn N Proline ProP GlutamineGln Q Arginine Arg R SerineSerS Threonine Thr T Valine Val V Tryptophan Trp W Tyrosine Tyr Y

A protein cartoon Sperm whale myoglobin (1MBN)

The Protein Folding Problem

Central Paradigm Central paradigm for Bioinformatics

Lecture 1 Sequence Alignment

Lecture 2 Hidden Markov Model

Lecture 3 Molecular Evolution and Phylogeny

Lecture 4 Microarray & Analysis

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