TUBERCOLOSIS Agis Terzidis, Paediatrician Spyridon Gialamas, Medical Doctor SEMINAR ON TROPICAL AND TRAVEL MEDICINE AT TTCIH IFAKARA 25 JUNE 2009

Estimated TB incidence rates, by country, 2007 Source: WHO

Trends in estimated incidence rates in nine subregions, Source: WHO

Progress towards the 70% case-detection target Source: WHO

Tuberculosis supranational reference laboratory network, 2007 Source: WHO

Countries that had reported at least one case of extensively drug-resistant TB Source: WHO

Global Fund commitments for TB control by region, as of end 2008 Western Pacific Region 20% (US$ 755 million) African Region 29% (US$ 1131 million) Southeast Asia Region 22% (US$ 867 million) European Region 13% (US$ 502 million) Region of the Americas 6% (US$ 229 million) Eastern Mediterranean Region 10% (US$ 382 million) Source: WHO

Objectives for 2006–2015 of the Working Group on New TB Diagnostics: address existing gaps in knowledge that are obstructing development of new diagnostic tools develop and evaluate a portfolio of new diagnostic tools and demonstrate their impact implement new diagnostic tools and ensure access to them Source: WHO

Strategic plan for 2006–2015 of the Working Group on New TB Drugs: Identification and validation of new targets for drugs, and candidate compounds drug development planning and execution of more effective clinical trials, including identification of improved biomarkers and methods of assessing latent disease clear and efficient regulatory guidance Source: WHO

Strategic plan for 2006–2015 of the Working Group on TB Vaccines: maintain and improve BCG vaccination programmes. The next generation of new vaccines introduced as an addition to BCG vaccines expand discovery and translation research on vaccines (“keeping the pipeline filled”) facilitate preclinical development of new vaccines build capacity at vaccine trial sites, providing opportunities for training and capacity strengthening

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