LJ-001.  Enveloped and Naked Viruses  Modes of Infection  LJ-001.

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Presentation transcript:

LJ-001

 Enveloped and Naked Viruses  Modes of Infection  LJ-001

Gary E. Kaiser

 Enveloped and Naked Viruses  Modes of Infection  LJ-001

Russell Kightley Media

Naked Naked Lytic cycle Exocytosis Enveloped Dan Stowell Botany Online Visual Resource Library

 Enveloped and Naked Viruses  Modes of Infection  LJ-001

 A small anti-viral molecule effective against enveloped (but not naked) viruses. Wolf et. al.

 Influenza A  Filoviruses  Poxviruses  Arenaviruses  Bunyaviruses  Paramyxoviruses  Flaviviruses  HIV-1  Hepatitis C  Ebola  And others

 Viruses can’t make their own proteins or repair their membrane like a cell can

Russell Kightley Media

Wolf et. al.

 Still very early in development, further testing needed  Shorten Viral Infection Course  Preventative Measure?  Could be put in condoms  New treatment for multiple viruses  Eliminate temporary infections  Fight Chronic ones  LJ001 is effective at very low doses  Potentially Excellent Therapeutic Index

 Russell Kightley Media  Virco Online  Humanitarian Futures Programme  Gary E. Kaiser  HOPES (The Huntinton’s Disease Outreach Project for Education) at Stanford  Molecular Station

 Wolf et. al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A Feb 16;107(7): Epub 2010 Jan 28.  Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol Aug;5(8):  Kudchodkar S., Levine, B. Viruses and Autophagy. Reviews in Medical Virology. 2009; 19:  Melikyan GB. Common principles and intermediates of viral protein- mediated fusion: the HIV-1 paradigm. Retrovirology Dec 10;5:111.

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