Research interests and techniques: Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. Hippocampal function: parvalbuminergic GABAergic interneurons and the control of neuronal oscillations GABAergic interneurons and motor learning Hypothalamic function: the regulation of neurons which make histamine: the tuberomammillary nucleus and sleep regulation Ion channels: GABA A receptors and K2P potassium channels Professor William Wisden

Neuronal type

Combination of methods used directly test circuit-specific functions of parvalbumin- positive interneurons in behaving mice Molecular technique transgenic mice and vector construct Region specific virus injection in vivo Electrophysiological recording Immunoflurescence staining Behavior test

Selective expression of TeLC in parvalbumin- positive interneurons of the hippocampus

Rostra –caudal axis

Blocking parvalbumin-positive cell–mediated inhibition in the hippocampus impairs spatial working but not reference memory parvalbumin-positive basket cells cholecystokinine (CCK)-containing basket cells (Cannabinoid sensitive parvalbumin-positive axo-axonic cells

Blocking parvalbumin-positive cell–mediated inhibition in the hippocampus impairs spatial working but not reference memory

Hippocampal lesion and inactivation disrupt both spatial reference and working memory A population of hippocampal CA1 interneurons selectively supports encoding of spatial working, but not incremental reference memory