Definition of Immunization Immunization Schedule Success of Immunization Assessment of Success Factors Influencing Success The Cold Chain
Non specific specific skin mucous membranes reflexes genetic sp. variation race anomalies acquired natural passive ( transplacental ) active ( disease ) artificial active toxoid live vacc killed vacc passive homologous Abs heterologous Abs Resistance Artificially acquired specific resistance
Vaccine: A suspension of attenuated live or killed microorganisms or antigenic portion of these agent presented to a potential host to induce immunity and prevent disease
Toxoid: A modified bacterial toxin that has been made nontoxic but remains the capacity to stimulate the formation of antitoxin
Antitoxin : An antibody derived from the serum of animals from stimulation with specific antigen used to provide passive immunity
Definitions Immunoglobulin: An antibody-containing solution derived from large pools of human plasma and used for passive immunization.
Attenuated strain of M.bovis. Safe in immunocompetent patient. 50 – 80% Protection against disseminated tuberculosis and tuberculus meningitis 50% protection against pulmonary tuberculosis in children and adults Route: intradermal.
IPV: Inactivated poliovirus, trivalent: type 1,2 & 3 OPV : live attenuated poliovirus trivalent: type 1,2 & 3 Vaccine administration: IPV = IM OPV = PO
Diphtheria and tetanus toxoids combined to a whole-cell pertussis (DPT) DTaP = diphtheria and tetanus toxoids combined to a cellular pertussis vaccine (less systemic and local side effects than DPT for children <7yrs) DT = for children <7yrs with contraindication to pertussis Td = tetanus toxoid with1/3 -1/6 the dose of diphtheria toxoid for individuals >7yrs Three doses in the first year, interval 2mo.
Consist of acapsular polysaccharide antigen conjugated to a carrier (doesn’t protect against the disease) Routine use of these vaccine has lead to a 95% decline in invasive Hib disease in infancy and young children. Vaccine administration :IM Haemophilus influenzae type B (Hib) vaccine
Indications: Routine All infant of HBsAg positive mother All children and adolescents not immunized High risk group: o Health workers. o Haemodialysis, bleeding disorders. o Travellers to endemic areas.
Introduction of pentavalent vaccine DTaP Hepatitis B Hib Route = IM
Live attenuated viruses.. Monovalent measles vaccine, rubella vaccine and measles/rubella MR formulations are available. Vaccine administration: SC MMR
The varicella vaccine is a live (attenuated) virus.live (attenuated) virus Vaccine administration : SC Two doses are always recommended.
Conjugate vaccine. Quadrivalent (Serogroups A, C, W-135 and Y) MCV4 is administered (IM). PCV Conjugate vaccine. Administered (IM). MCV4
Rota V V Live attenuated Given orally in 2 doses
Birth 2 mo 4 mo 6 mo 9 mo 12 mo 18 mo 24 mo School entry BCG DTaP 1 DTaP 2 DTaP 3 Measles 1 (mono) M 2 MR 1 DTaP B1 HepAV 2 DTaP B2 HepBV 1 HibV 1 HibV 2 HibV 3 OPV 4 HibV B OPV B2 IPV 1 IPV 2 IPV/OPV 3 OPV B1 M 4 MR 3 Varicella 2 HepBV 2 HepBV 3 HepBV 4 HepAV 1 PCV 1 PCV 2 PCV 3 PCV B /Td Rota MCV4 Varicella 1 M 3 MR 2 vaccineinformation.org
- Coverage - Seroconversion
- Parents - Staff - Vaccine KAP Proximity Commitment Skill Efficacy Stability ( H.E. ) ( √ ) ( Selection ) ( Training ) ( Choice ) ( Cold Chain )
It is a temperature-controlled supply chain. It is a system of storage, transport and distribution of vaccines at a low temperature from manufacturer to the actual vaccination site. Cold chain
Manufacturer Ground Transport AirportAirplane Airport Terminal Intermediate Stops& Transfers Distributor’s Warehouse Consumer Outlet Consumer Pharma / Biotech Cold Chain Destination
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