Not to be distributed without permission Using SciFinder Scholar as a Research Tool HBZ Meeting Paul Peters, Manager European Marketing Taken from presentation by Prof. Damon Ridley School of Chemistry University of Sydney NSW 2006 Australia

Not to be distributed without permission Copyrights – SciFinder Scholar screens are reproduced with permission of the Chemical Abstracts Service, a Division of the American Chemical Society – CAPLUS, REGISTRY, and CASREACT data is copyright the American Chemical Society and reproduced with permission – Data from Journal of the American Chemical Society is copyright the American Chemical Society and reproduced with permission – Data from Angewandte Chemie International Edition is copyright John Wiley & Sons Inc. and reproduced with permission

Not to be distributed without permission Searching for information What sources do you currently use? Why have you chosen these sources? How do they compare with other sources? – in content – in ease of use – in search opportunities – in quality! – (in price) What information are you missing? Search skills?

Not to be distributed without permission Searching the literature Is very complicated! The “text book” approach for electronic information retrieval is to – start with general searches – examine initial results – modify search This helps: – overcome some of the difficulties relating to different terminologies (used by authors and database producers) – alert us to new opportunities So, it helps to ….

Not to be distributed without permission …apply Scientific Method to Information Retrieval!

Not to be distributed without permission Databases in SciFinder Scholar Over 23.5M bibliographic records (CAPLUS) – from over 9,000 serials – from over 35 patent issuing organizations – from 1907 – updated daily Over 13.7M bibliographic records (MEDLINE) – from over 4,300 serials – from 1958 – updated 4 times weekly Over 61M substances/sequences from 1907 (REGISTRY)substances/sequences Over 7.5M chemical reactions from “1974*“ (CASREACT) Inventory Information (CHEMLIST) Commercially available substances (CHEMCATS) * some earlier information available and more is being added

Not to be distributed without permission Search opportunities in SciFinder Scholar SciFinder Scholar has over 50 search options including: – Topics – Authors – Companies – Substances by name by formula by structure by substructure – Citations – Reactions SciFinder Scholar has an unique interface, and the key to its use as a research tool is to understand the Analyze/Refine and Get Related options!

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Not to be distributed without permission SciFinder Scholar “This is a magic tool”

Not to be distributed without permission (Database Content:) Original Article....

Not to be distributed without permission Bibliographic Database Record The record we search consists of author terms... The Chemical Abstracts Service bibliographic database DatabaseContentDatabaseContent

Not to be distributed without permission Bibliographic Database Record...and terms added by the indexers... this is how substances are indexed! these are the ‘roles’ for substances Indexing is very important! DatabaseContentDatabaseContent CA Section Title

Not to be distributed without permission Original article ReactionSearchReactionSearch

Not to be distributed without permission CAPLUS Record Abstract written by Indexer! ReactionSearchReactionSearch Information on reactions in title and abstract

Not to be distributed without permission CAPLUS Record ReactionSearchReactionSearch Information on reactions in indexing … all in CAPLUS!

Not to be distributed without permission CASREACT Record All the atoms, bonds, functional groups in starting material and products are included in the database record ReactionSearchReactionSearch

Not to be distributed without permission Searching Bibliographic Databases We are searching entries written by authors and by indexers. It helps if we try to think how they may have written about the topic of interest to us. (It helps if authors remember that most people will find articles through electronic databases, so write your titles and abstracts with this in mind!) SciFinder Scholar automatically helps us in many ways, but we still need to “apply Scientific Method in information retrieval”. DatabaseContentDatabaseContent

Not to be distributed without permission Substance Database Record There are many issues relating to the indexing of substances, and we shall learn some of them soon The Chemical Abstracts Service substance database DatabaseContentDatabaseContent

Not to be distributed without permission Reaction Database Record There are many issues relating to building reaction databases, and we shall learn some of them soon The Chemical Abstracts Service reaction database DatabaseContentDatabaseContent

Not to be distributed without permission Topic Search The topic we are going to discuss may not interest you - but please consider the process and then try to think how to use the functionality to facilitate your research We shall see how to work through the problem - using Scientific Method! TopicSearchTopicSearch The topic: – how to analyze for benzaldehydes in sake

Not to be distributed without permission Initial Search: Selection of Candidates TopicSearchTopicSearch Use prepositions Identifies concepts Finds synonyms Attempts truncation 

Not to be distributed without permission Research Topic: 1,590 references TopicSearchTopicSearch   

Not to be distributed without permission Post-Processing Analyze/Refine – tools to narrow answers – Take them in steps so that we understand what we are retrieving and what we are omitting TopicSearchTopicSearch Get Related – tools to “expand” answers – Get additional information: citations, substances, reactions, Internet

Not to be distributed without permission To narrow answers ….Analyze/Refine Many options Take them in steps so that we understand what we are retrieving and what we are omitting TopicSearchTopicSearch

Not to be distributed without permission Analyze References: CA Section Title 80 Section Titles Very useful for initial filtering of answers TopicSearchTopicSearch

Not to be distributed without permission More precise answers (572) TopicSearchTopicSearch

Not to be distributed without permission Analyze References: Index Term >30,000 Index Terms for Topics >125,000 Index Terms for organisms etc Systematic entries Very useful! TopicSearchTopicSearch

Not to be distributed without permission 494 Answers... TopicSearchTopicSearch

Not to be distributed without permission Where are we? We did a search: “analysis of (benzaldehydes in) sake” We found the algorithm retrieved hits (>1500) with: – Sakhalin – sakuraii... We restricted answers (Analyze References): – to CAPLUS – to Sections of Chemical Abstracts (broad refinement) – to Index Terms (more precise refinement) – 494 answers But…. How do we find the ‘benzaldehydes’? And how do we analyze for them in sake? TopicSearchTopicSearch

Not to be distributed without permission Refine References: Research Topic TopicSearchTopicSearch

Not to be distributed without permission Refine References: Research Topic TopicSearchTopicSearch

Not to be distributed without permission Get Related: Expanding our search! TopicSearchTopicSearch

Not to be distributed without permission Refine Substances: Structure TopicSearchTopicSearch

Not to be distributed without permission The Benzaldehydes indexed in the 494 References Now we have to find references to the analysis of these substances in sake TopicSearchTopicSearch

Not to be distributed without permission Get References: Analytical Study TopicSearchTopicSearch

Not to be distributed without permission Refine by Research Topic TopicSearchTopicSearch

Not to be distributed without permission (Final) Answer Set! 7 answers TopicSearchTopicSearch Including ….

Not to be distributed without permission Abstract and Indexing TopicSearchTopicSearch

Not to be distributed without permission Get Related: Substances Function = > structure The ability to find substances with specific properties/ functions is a key area: – What proteins/sequences have I need? – What monomers/polymers are useful for miniemulsions? – What natural products have been isolated from these organisms? – What phthalocyanines/porphyrins have been used in photodynamic therapy? – What polymers have been used for automobile brakes? – What antidiabetic agents are known? – What drug formulations have been used in gene therapy? – What co-ordination compounds has Dave Garner reported recently? TopicSearchTopicSearch

Not to be distributed without permission Summary SciFinder Scholar applies intelligence at the initial search level – relevance ranked list of candidates - choices! – automatic application of synonyms SciFinder Scholar provides post-processing tools – Narrowing answers Analyze/Refine References - indexing! – Additional information (broadening answers) Get Related – citations – substances – reactions TopicSearchTopicSearch