Particle Based Drug Delivery Systems References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery.

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Presentation transcript:

Particle Based Drug Delivery Systems References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 2, Week 6

Solvent Casting Method

POLYMER-DCM SOLUTION ADD TO PVA IN WATER & MIX SECONDARY EMULSION (W/O/W) SOLVENT EVAPORATION FILTRATION AND DRYING PRIMARY EMULSION (W/O) ULTRA SONICATION PROTEIN SOLUTION Double Emulsion Method

Inlet temperature Polymer concentration Pump feed rate Aspirator ratio Compressed air flow rate Drug loadings Spray Dried Microspheres

Microsphere surface morphology using different polymer solution concentrations AB D C F.J. Wang and C.H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”, J. Controlled Release, (2002).

Degradation of microspheres PLGA 65:35 1 month PLGA 50:50 1 month PLGA 85:15 3 month PDLA 3 month F.J. Wang, T.K.Y. Lee and C.H. Wang, “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, (2002)..

Modulation of release by PEG small discs (diameter = 5mm, thickness =1mm) large discs (diameter =13mm, thickness = 1mm ) F.J. Wang, T.K.Y. Lee and C.H. Wang, “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, (2002).