Efector functions of CD4 + and CD8 + T-cells

Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Defense- helmints Defense- extracellular bacteria, fungi Organ-specific autoimmune diseases Allergy Autoimmunity and chronic inflammation

Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 IL-4 IL-12 IL-23 T-bet GATA-3 ROR  t IL-4 IL-5 IL-13 Macrofage activation B-cells Eosinophil activation B-cells… Neutrophil activation... IL-17 IL-22 IFN-γ

T H 1 response

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells Macrophage activation at the site of infection

Efector functions of T H 1 cells B-cell activation

Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Defense- helmints Defense- extracellular bacteria, fungi Organ-specific autoimmune diseases Allergy Autoimmunity and chronic inflammation

T H 2 response

Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Defense- helmints Defense- extracellular bacteria, fungi Organ-specific autoimmune diseases Allergy Autoimmunity and chronic inflammation

T H 17 response

Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Defense- helmints Defense- extracellular bacteria, fungi Organ-specific autoimmune diseases Allergy Autoimmunity and chronic inflammation

CTL effector function

Mechanisms of CD8 + T-cell cytotoxicity

Mechanisms of CD8 + T-cell cytotoxicity

Mechanisms of CD8 + T-cell cytotoxicity

Mechanisms of CD8 + T-cell cytotoxicity

CD8 + CTL Target cell Mechanisms of CD8 + T-cell cytotoxicity

CD8 + CTL perforin Target cell Mechanisms of CD8 + T-cell cytotoxicity

granzimi apoptosis CD8 + CTL perforin Target cell Mechanisms of CD8 + T-cell cytotoxicity

FasL CD8 + CTL Target cell Mechanisms of CD8 + T-cell cytotoxicity

Ciljna ćelija FasLFas apoptosis CD8 + CTL Mechanisms of CD8 + T-cell cytotoxicity

Pathogens avoid cellular immunity Inhibition of fusion of phagosome with lysosome

Inhibition of presentation of viral antigens 0

Inhibition of immune response by virokines and viroreceptors

killing virus-infected and tumor cellsj.CTL killing mechanisms are10. perforin, granzymes, Fas-FasL interaction i.CTL effector function is 9. intracellular pathogensh. IL-178. IFN-γ production and macrophage activationg. IL-4 and IL-13 induce also7. mobilises and activates neutrophilsf. T H 2 subpopulation induces6. alternative macrophage activatione. T H 2 cells are important for defense against 5. T H 1, T H 2 i T H 17d.T H 2 effector function is4. helminatsc.T H 1 cells are important for defense against 3. Inflammatory reaction rich in eosinophils b. T H 1 effector function is2. production of IL-4, IL-5, IL-13a.Subpopulations of efektor CD4 + T- cells are 1. 1._____2._____3._____4._____5._____6._____7._____8._____9._____10.____ d.g.h.a.c.b.e.f.j.i.