2. Immunity to infectious agents

3. Immunity to extracellular bacteria
Disease is caused by two mechanisms:
First ,inflammation
Second,toxins(endotoxins,exotoxins)

4. Innate immunity Complement activation Phagocytosis
Inflammatory response

5. Adaptive immunity to extracellular bacteria
Antibodies
a)Neutralization
b)Opsonisation
c)Complement activation
Protein antigens of ex. Bacteria Activate Ths
activation of macrophages and neutrophils
Local Inflammation
stimulate antibody production

6. Injurious effects of immune response
Inflammation
Septic shock (circulatory collapse and DIC)
Microbial component macrophages
cytokines(TNF,IL-1,IL-6)
Superantigens
Rheumatic fever
Nephritis

7. Immunity to intracellular bacteria
Innate immunity
Phagocytes and NK cells
DC and Macroph IL-12 ,IL-15
Nk cells activation
IFN-
macrophage activation

8. Adaptive immunity
T CD4
T CD8

9. Immunity to viruses
Innate immunity
Adaptive immunity
Antibodies
CTL