EFFECTS OF ULTRAVIOLET RADIATION Henry W. Lim, MD Co-Chair National Council on Skin Cancer Prevention.

Slides:

Advertisements

Similar presentations

UV radiation By Andrew Coventry 10LC.

Advertisements

REGULATING INDOOR TANNING WORLDWIDE Lawrence Green, MD, FAAD Board Certified Dermatologist Rockville, Maryland.

Sunlight, Sun Damage and Protection from Radiation There are five forms of radiation. Ranging from 100-1,000,000 nm in wavelength.

Frederick C. Fehl, III MD Dept of Dermatology SCPMG San Diego

Update on skin cancer and artificial tanning Loraine Marrett May 2007.

This grey area will not appear in your presentation. Skin Cancer Prevention: Indoor Tanning Presentation prepared by: Canadian Cancer Society, Ontario.

Afreen Pappa, MD JAV Ᾱ NI Med Spa. At the conclusion of this presentation, participants will:  Understand the effect of UV rays on skin  Be able to.

FDA Device Panel Meeting Tanning Bed Classification Suraj Venna, MD, FAAD Director, Melanoma Center Washington Cancer Institute Washington, DC March 25,

THE BED IS DEAD LEARN THE FACTS ABOUT UV AND THE HEALTH RISKS OF TANNING.

Etiology Of Cancer &Carcinogenic Agents

Sunscreen UV Ultraviolet Light and SPF. UVA (ultraviolet-A)  Long wave solar rays of nanometer (billionths of a meter).  Although less likely.

 Cancer - information and treatment Cancer - information and treatment.

Are you dying to be dark? The deadly secrets of tanning will be revealed in this presentation. By: Christine M., Adrianne S., Amanda C., & Jordyn B.

What do UV rays do to the skin? By: Meredith Walker.

DNA Week 2 1. DNA Review DNA Cell cycle Proteins Flow of information 2.

DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.

What is skin cancer?What is skin cancer?  “The uncontrolled growth of abnormal skin cells.” (Skin Cancer Foundation)  Occurs when unrepaired DNA damage.

Skin Cancer: What You Should Know Randy R. Weigel University of Wyoming Cooperative Extension Service.

Skin Cancer Prevention Program Presented By: Cheryl Barber Spires OSU Extension, Fulton County, Maumee Valley EERA Prepared by: Dee Jepsen, Sereana Howard.

It’s just a tan. One person dies of melanoma every hour (every 57 minutes) Melanoma is the most common form of cancer for young adults years old.

Ozone Loss and Skin Cancer. Problem Susan Solomon found the correlation between the disappearance of ozone and increased concentration of chloroflurocarbons.

Mary Maloney, MD, FAAD Director of Dermatologic Surgery University of Massachusetts Medical School.

History of UV-C Technology

Integumentary System Skin Disorders and Diseases.

Biomedical Science Skin Cancer:. Skin Cancer Most common cancer in US Fastest increasing cancer in US 1,000,000 people had some form of skin cancer in.

Action spectrum (approximate) for the induction of erythema in human skin, and average intensity at the earth’s surface. The figure also.

Artificial Tanning Joshua Langhorne, MD Janienne Kondrich, MD Community Pediatrics Legislative Advocacy Project.

The Integumentary System The skin (cutaneous membrane) and its accessory structures.

SKIN CANCER Senior Health-Bauberger. SKIN CANCER Skin cancer is the most common form of cancer in the United States The two most common types of skin.

FDA GPSD Advisory Panel Mtg on Sunbed Safety Manny Karos B.S.UMD USC MS. Systems MgtSafety Retired FDA, CSO, Sunlamps Formerly Adjunct Faculty UMD, Systems.

DEATH AT HIGH NOON. ELECTROMAGNETIC SPECTRUM.

SKIN CANCER. How Cancer Occurs  Cancer develops only in cells with damaged genes (mutations).  If the genes that regulate the cell cycle are damaged,

Indoor Tanning and Melanoma: A Direct Link Darrell S. Rigel, MD Clinical Professor, New York University Medical School Past President – American Society.

The Dangers of Skin Cancer Are we educated enough?

Indoor Tanning Beds: A Serious Threat to Public Health William D. James, MD, FAAD President American Academy of Dermatology Association March 25, 2010.

Skin Cancer Sylvie Sabones. Skin Cancer Most common cancer in US Fastest increasing cancer in US 1,000,000 people had some form of skin cancer in 2003.

Skin CancerMelanomaSun & TanningPotpourri

SKIN CANCER PREVENTION & IDENTIFICATION. Why is skin cancer important?  the most common type of cancer in the United States  about 40 to 50 % of Americans.

Effects On Tanning Beds

Sunless Tanning By John Maguire.

Tanning. Avae Marcello.

Excessive Sun Exposure in teenage females Shannon Dembowske Crystal Thayer Erin Scarbrough-Raden.

SUN SAFETY TERMINOLOGY. ABCD RULE  A way to tell the difference between a regular mole and one that may be skin cancer  Asymmetry  Border  Color 

Ultraviolet Waves By Lilli Schussler and Emily Madrigal.

Kelley Redbord, MD, FAAD Board Certified Dermatologist Dermatology and Dermatologic Surgery Group of Northern Virginia Vienna, Virginia March 25, 2010.

How is Asian/Chinese Skin different for photodamage?

Human Bio 11. *Ultraviolet radiation has three different wave lengths – UV-A, UV-B, and UV-C. UV-Astarts the tanning process before the skin burns and.

November 13, 2007 Chapter: 31 Title: Noninfectious Diseases and Disabilities Lesson : 2 Title: Skin Cancer Grade Level: High school freshman health class.

SKIN CANCER. How Cancer Occurs  Cancer develops only in cells with damaged genes (mutations).  If the genes that regulate the cell cycle are damaged,

Update sunscreen 2015 Krisada Duangurai M.D..

 Skin Cancer In Young Adults Kerry Phifer Maddie Walsh.

SKIN CANCER PREVENTION May Background Information PART ONE.

Ultraviolet (UV) Radiation, Skin cancer and the Ozone layer A type of electromagnetic radiation.

Melanoma By Liam Hanrahan. What is Melanoma? Melanoma is the fourth most common cancer, usually appearing as a pigmented skin lesion. Australia has the.

Skin Cancer. Skin Cancer: The Facts The most common cancer in the United States – Approximately 2 million people are diagnosed annually The number one.

The Facts About Indoor Tanning. SAM Mission To assist the Richard David Kann Melanoma Foundation to carry out their mission: The early detection and prevention.

The Skin Cancer Problem

Sun induced skin diseases

“The World We Create” NATS 101 Section 6

Case Study Read page 84.

effect of ultraviolet on bacterial cells

Deon Wolpowitz, MD, PhD, Barbara A. Gilchrest, MD

SUNSCREEN AGENTS.

The Facts About Indoor Tanning

Telomere-Mediated Effects on Melanogenesis and Skin Aging

An α-MSH Analog in Erythropoietic Protoporphyria

Jean Cadet, Thierry Douki Journal of Investigative Dermatology

Presentation transcript:

EFFECTS OF ULTRAVIOLET RADIATION Henry W. Lim, MD Co-Chair National Council on Skin Cancer Prevention

PRESENTER Chairman, Department of Dermatology, Henry Ford Hospital, Detroit, MI Photodermatology

DISCLOSURE Consultant : La Roche- Posay/L’Oreal, Orfagen, Dow Pharmaceutical Sciences Investigator: Johnson & Johnson

ELECTROMAGNETIC RADIATION

ULTRAVIOLET RADIATION UV λ (nm)Properties UVC Germicidal UVB Sunburn UVA Pigment darkening, tanning

EFFECTS OF UV DNA damage Erythema Tanning Vitamin D synthesis Immunosuppression Skin cancer

EFFECTS OF UV DNA damage

UV AND DNA DAMAGE UVB: Direct effect Cyclobutane-pyrimidine dimers Bolognia, et al. Dermatology. 2008

UV AND DNA DAMAGE (Agar NS, PNAS 4/04; 101:4954; Budiyanto A, P&P10/02; 76:397) UVA: Indirect mechanism Absorption by skin chromophores → reactive oxygen species → reacts with guanine → oxidative products (8- oxoG, 8-oxo-dG) Mutagenic

EFFECTS OF UV DNA damage Erythema

ERYTHEMA Primarily the effect of UVB Peaks at 24 hrs

EFFECTS OF UV DNA damage Erythema Tanning

MECHANISMS OF TANNING (Hönigsmann H, PPP 4/02; 18:75) UV: activation of tyrosinase UV  DNA damage  nucleotide fragments excised in repair  stimulate melanogenesis

ERYTHEMA & TANNING UVB: Erythema > tanning UVA: Tanning > erythema Tanning is an indication that DNA damage has occurred There is no “safe tan”

EFFECTS OF UV DNA damage Erythema Tanning Vitamin D synthesis – Action spectrum: UVB

EFFECTS OF UV DNA damage Erythema Tanning Vitamin D synthesis Immunosuppression Skin cancer

UV: IMMUNOSUPPRESSION AND SKIN CANCER (International Agency for Research on Cancer Working Group on artificial ultraviolet light and skin cancer. Green A, et al. Int J Cancer 3/07; 120:1116) UV: immunosuppressive Chronic UV exposure: – Photoaging changes – Squamous cell carcinoma – Basal cell carcinoma Tanning bed users: – Melanoma – Squamous cell carcinoma

NATURAL AND ARTIFICIAL UV DNA damage, immunosuppression, skin cancer WHO: UV is carcinogen WHO: UV tanning beds: “carcinogenic to humans.” (El Ghissassi F, Lancet Oncol 7/09; 10: 751)

NCSCP RECOMMENDATIONS To reclassify sunlamps for tanning as Class II devices To impose special controls: user labeling and user registry To prohibit use by consumers younger than 18 years To require license for facilities at which sunlamps may be used To have training and certification of operators