IL-2 as the adjuvant in FMD vaccine Chunxia su ， ph.D. Ningxia Medical University Yinchuan ， China.

Slides:

Advertisements

Similar presentations

Advertisements

Immunity to Infectious Diseases

Chapter15 B cell mediated immune response. B cells mediated immune response Humoral immunity(HI) or antibody mediated immunity: The total immunological.

Introduction to Immunology BIOS 486A/586A Kenneth J. Goodrum,Ph.D. Department of Biomedical Sciences Ohio University 2005.

Potential prophylactic BCG Prime-booster Gaëlle Noël Kidist Bobosha Subgroup A2 March 16 th, 2011.

Immune System First Line Defenses. Second Line Defense: Inflammatory Response.

How Flow Cytometry can be used in Vaccine Research (Buffalo Presentation, 6/11/2012)

HOW VACCINE PROVIDES PROTECTION STIMULATORY MOLECULE SECRETIONS B CELL MACROPHAGE Step1 Macrophage takes in antigen by phagocytosis Step2 Macrophages display.

Immunity to Infectious Diseases BIOS 486A/586A K.J.Goodrum 2006.

Defenses Against Infection 1. Innate responses (humoral and cellular) 2. Immunity to intracellular pathogens NK cells, control of Th1/Th2 responses 3.

Immune Response against Infectious Diseases

T cells Jan Novák. The immune system Protection against infectious agents Clearance of dying, damaged and dangerous cells Regulation of the immune responses.

Vaccines Polio - close to eradication. In 2001 >1000 cases worldwide; last wild case in Americas in Peru in 1991.

Cytokines Department of Microbiology. Important terms Cytokines: Proteinaceous messenger molecules of low molecular weight (usually of less than 30kDa),

Types of vaccines 1 - First generation vaccines are whole-organism vaccines - either live and weakened, or killed forms. [1] Live, attenuated vaccines,

Novel strategies for prevention and treatment of HIV infection Prasit Faipenkhong Pairoaj Vonghathaipaisarn Rodjana Chunhabundit Zhang Jianjun.

Musketeers Course October The Mucosal Immune System The organization of the mucosal immune systemThe organization of the mucosal immune system The.

Phagocyte. B cells Receptor B Cell Naïve B cell B cells and antibodies daughter cells produce antibodies phagocyte consumes an antibody coated virus.

IMMUNOLOGICAL MEMORY The immune system seems to „remember” previous infections, Which cells do it and how? Why? For how long? How can we use this to fight.

Viral Vaccine Types Viruses are inactivated with chemicals such as formaldehyde. Inactivated (killed) vaccines cannot cause an infection, but they.

Chapter 15 B cell mediated immune response. B Cells Lymphocytes that react directly with antigens Require stimulation from Helper T Cells Offspring become.

Lecture 15 Vaccines. History Turkey- smallpox from sick person into veins of well person Variolation- mortality rate- 1% Edward Jenner received.

Specific Immune System

The Immune System. Function The immune system functions to provide protection from disease causing agents in the one’s environment Pathogens include viruses,

Adaptive immunity – B cell

Lecture #10 Aims Describe T cell maturation and be able to differentiate naïve and effector T cells. Differentiate the development and functions of Th1.

MICR 304 Immunology & Serology Lecture 6 NK Cells, Lymphocytes Chapter 1.4 –1.17; 2.30 – 2.33 Lecture 6 NK Cells, Lymphocytes Chapter 1.4 –1.17; 2.30 –

Immunotherapy By: Ray & Kelly Lewis David Duke Catherine Hanson Richard Hildreth.

VAKSIN. INTRODUCTION AND HISTORY Vaccination can be defined as a deliberate attempt to induce protection against disease with the goal of inducing active.

Vaccines: A Molecular View

___________DEFENSES of the HOST: THE IMMUNE RESPONSE

14. Immunodiagnosis, Immunotherapy & Vaccination 王家鑫， MD College of Veterinary Medicine.

HUMAN IMMUNODEFICIENCY VIRUS AND ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)

Chapter 10. Cell-mediated immunity (CMI) is the type of host defense that is mediated by T lymphocytes, and it serves as a defense mechanism against.

11. B Cell Recognition and Response to Antigens 王家鑫王家鑫.

CATEGORY: VACCINES & THERAPEUTICS HIV-1 Vaccines Shokouh Makvandi-Nejad, University of Oxford, UK HIV-1 Vaccines © The copyright for this work resides.

B Cell Activation Abul K. Abbas UCSF FOCiS.

Viral vaccines .

Vaccine; To be effective  Must stimulate as many of the body's defence mechanisms as possible.  It is not necessary to get 100% uptake of vaccine in.

Acute Radiation Syndromes. Implications for Immunotherapy

Activation of T Lymphocytes

HIV-1 Vaccines Shokouh Makvandi-Nejad, University of Oxford, UK

CATEGORY: CELLS TH17 CELLS

B Cells and Antibodies Abul K. Abbas UCSF FOCiS.

T cell differentiation

Scientific Challenges for the Development of an HIV Vaccine

Immune system-Acquired/Adaptive immunity

CELL-MEDIATED IMMUNITY RAHUL KUMAR LOHANA 2K16/MB/50 INSTITUTE OF MICROBIOLOGY UNIVERSITY OF SINDH, JAMSHORO.

Figure 2 Cell-mediated disease mechanisms of lupus nephritis

Heating is a multifunctional adjuvant that affects tumor microenvironment through several intrinsic and extrinsic mechanisms, which could enhance immunotherapy.

Differentiation and Functions of CD8+ Effector T Cells

Nat. Rev. Nephrol. doi: /nrneph

Vaccine Differentiation Group

Interleukin-17 Kick-Starts T Helper 1 Cell Differentiation

Zika Virus: Immunity and Vaccine Development

What is a T-independent antigen?

Humoral and Cell Mediated Immunity

Figure 1 Mucosal immune networks

NKTeeing Up B Cell Responses to Viral Infection

Figure 2 Biologics that target CD4+ T helper (TH)-cell subsets

Figure 1 Sequence of events in the development of autoimmune nephritis

Th1 and Th2 immune responses

IL-7 Knocks the Socs Off Chronic Viral Infection

Lec.10 Immune response كلية المأمون الجامعة\قسم تقنيات التحليلات المرضية مادةالمناعة-النظري/المرحلةالثالثة م.م.رشد اياد عبدالحميد.

Figure 1 The role of macrophages in RA

Keeping STATs on Memory CD8+ T Cells

TSLP and Th2 Cells TSLP TSLP TSLP

General overview of innate and adaptive immune responses to and regulation of black yeasts. General overview of innate and adaptive immune responses to.

Cytokines and cytokine receptors involved in type I immunity in tuberculosis. Cytokines and cytokine receptors involved in type I immunity in tuberculosis.

Presentation transcript:

IL-2 as the adjuvant in FMD vaccine Chunxia su ， ph.D. Ningxia Medical University Yinchuan ， China

Overview of FMD Foot-and-mouth disease (FMD) is a severe, highly contagious and economically devastating viral disease worldwide.

Overview of FMD vaccine Inactivated antigen vaccines have been available since the early 1900s.

Overview of FMD vaccine Shortcomings of traditional vaccines for FMD ： First, there are so many different strains of the FMD virus; Second, traditional vaccines involve live FMD virus; Third, traditional vaccines can not differentiate infected from vaccinated animals.

Overview of FMD vaccine The need for better foot-and-mouth disease (FMD) vaccines is not new. subunit vaccine live vector vaccine Nucleic acid vaccines Novel attenuated vaccine Synthetic peptide vaccine

Overview of FMD vaccine Humoral immune response was considered to be an important defence mechanism in FMD infection. In recent past, there has been an increasing evidence of the importance of T cell mediated immunity in FMD.

Overview of FMD vaccine In recent years, special attention has been paid to cytokines as FMD vaccine adjuvants. IFNα,β,γ;IL-2,IL-6,IL-9,IL-18,IL-15,TNFα,IL-1β

IL-2 is a very popular adjuvant IL-2 is one of the most widely used adjuvants for vaccination to stimulate the proliferation and activation of various immune effector cells such as T cells, NK cells, B cells, and macrophages.

IL-2 is a very popular adjuvant IL-2 enhanced the immunogenicity of the FMD DNA vaccine candidate. H.-T. Wong et al. Vaccine,2002

IL-2 is a very popular adjuvant IL-2 was able to enhance the specific immune response against FMD virus type O, A22 and Asia 1. S. Yadav et al. Vaccine,2005

IL-2 is a very popular adjuvant IL-2 is important in many types of T effector cell differentiation.

T follicular helper cells (Tfh), a new specialized subset of CD4+ helper T cells ， providing help to B cells.

Ma C S et al. J Exp Med 2012;209: © 2012 Ma et al.

Su C,et al. PLoS One ， 2013

PNA+

Su C,et al. PLoS One ， 2013 rAd5VP1 induced the secretion of IL-21 and the expression of Bcl-6 mRNA.

Can IL-2 as an adjuvant for FMD vaccine candidate promote the generation of T follicular helper cells ？

PNA+

summary IL-2 as an adjuvant for an adenovirus-vectored FMD vaccine candidate through the generation of Th1, Th2 as well as T follicular helper cells.

acknowledgement Xiangguo Duan ， Ph.D. Guanxian Xu ， Ph.D. Jie Zheng ， graduate student Feng Wang ， graduate student

Liao et al, Immunity,2013

Thomas R. Malek, Wasif N. Khan. Immunity 2012

Oestreich et al. Nat Immunol ， 2013