Non-Conventional Preservation Tim Kapsner Senior Research Scientist Aveda Corporation
“Classic” Preservatives Diazolidinyl Urea Diazolidinyl Urea Quaternium-15 Quaternium-15 Sodium Hydroxymethylglycinate Sodium Hydroxymethylglycinate Kathon Kathon Parabens Parabens DMDM Hydantoin DMDM Hydantoin Chloroxylenol Chloroxylenol
Common “Non-Conventional” Preservatives Organic (Benzoic, Sorbic) Acids and salts Organic (Benzoic, Sorbic) Acids and salts Benzyl Alcohol Benzyl Alcohol Phenoxyethanol Phenoxyethanol
Naturally Derived Antimicrobials
Grapefruit Seed Extract Aka carrier for Triclosan, Benzethonium Chloride, Benzalkonium Chloride
Lonicera (Honeysuckle) Extract Aka carrier for Sodium Hydroxymethylglycinate
Hinokitiol Extracted from Japanese pine tree Extracted from Japanese pine tree $1500/kg synthetic, $2500/kg natural $1500/kg synthetic, $2500/kg natural Effective at 0.01 to 0.05% Effective at 0.01 to 0.05% Broad spectrum Broad spectrum Difficult to dissolve Difficult to dissolve Odor Odor
And Many Others NET-DTB (Barnet) NET-DTB (Barnet) Halogenine (Natural Cl, Br) Halogenine (Natural Cl, Br) GP-150 (Global Preservatives, acid blend) GP-150 (Global Preservatives, acid blend) Polylysine (Ajinomoto) Polylysine (Ajinomoto) Ethanol Ethanol
Essential Oils Lemongrass Oil Lemongrass Oil Lemon Tea Tree Oil Lemon Tea Tree Oil Tea Tree Oil Tea Tree Oil Lippia Sidoides Lippia Sidoides Origanum Oil Origanum Oil
Vendor Blends of Natural Stuff
Vendor Blends Natrulon PCG (Potassium sorbate, cinnamomum cassia leaf oil, alcohol) Natrulon PCG (Potassium sorbate, cinnamomum cassia leaf oil, alcohol) Lema Oil (Tea tree derivative) Lema Oil (Tea tree derivative) Biopein (extract of origanum, thyme, cinnamon, rosemary, lavender, golden seal), Neopein, Suprapein Biopein (extract of origanum, thyme, cinnamon, rosemary, lavender, golden seal), Neopein, Suprapein
Functional Ingredients that are also Antimicrobial
Emulsifiers
Phospholipids Phospholipid P-TC (Cocamidopropyl PG- Dimonium Chloride Phosphate) Phospholipid P-TC (Cocamidopropyl PG- Dimonium Chloride Phosphate) Phospholipid C-DM (Capryl...) – more functional, more irritating Phospholipid C-DM (Capryl...) – more functional, more irritating Phospholipid P-TM (Myristyl...) -- new Phospholipid P-TM (Myristyl...) -- new
Glyceryl Esters Glyceryl Laurate (Lauricidin, Dr. Kabarra) Glyceryl Laurate (Lauricidin, Dr. Kabarra) Glyceryl Caprate (Lexgard GMC, Inolex) Glyceryl Caprate (Lexgard GMC, Inolex) Glyceryl Caprylate (Capmul 708G, Abitec) Glyceryl Caprylate (Capmul 708G, Abitec)
Emollients/Solvents PCA Ethyl Cocoyl Arginate (CAE) PCA Ethyl Cocoyl Arginate (CAE) Ethylhexylglycerin (Sensiva SC-50) Ethylhexylglycerin (Sensiva SC-50) Capryloyl Glycine (Lipacide C8G) Capryloyl Glycine (Lipacide C8G) Capryl Glycol (Lexgard O) Capryl Glycol (Lexgard O) Glycine Glycine Olive Leaf Extract (Eurol BT) Olive Leaf Extract (Eurol BT)
Organic Acids Benzoic (pK 4.19) Benzoic (pK 4.19) Sorbic Sorbic Salicylic (pK 2.97) (OTC active, acne) Salicylic (pK 2.97) (OTC active, acne) Usnic Usnic Tartaric (pK 4.34) Tartaric (pK 4.34) Malic (pK 3.4, 5.11) Malic (pK 3.4, 5.11)
Organic Acids pH restrictions pH restrictions pH drift pH drift Irritation Irritation
Phenoxyethanol vs. Phenethyl Alcohol Rose Ether $3.5/kg Synthetic $5/kg Natural $2000/kg
Plant Extracts Microplate MIC (Minimum Inhibitory Concentration)
Microplate MIC Method E.coli (Germall (0.04%) /Lippia (0.33%) 100 % Growth Blank GermallLippia
Microplate MIC Method E.Coli (Germall (0.04%) /Lippia (0.33%) Colorimetric Dye Resazurin Blank Blank = No Growth (Blue) 100% Growth (Red) GermallLippia
Plant Extract MIC Germall II % Germall II % Plant Extract Fraction 1 – 0.060% Plant Extract Fraction 1 – 0.060% Plant Extract Fraction 2 – 0.084% Plant Extract Fraction 2 – 0.084% Plant Extract Fraction 3 – 0.11% Plant Extract Fraction 3 – 0.11% Plant Extract Fraction 4 – 0.068% Plant Extract Fraction 4 – 0.068%
THANK YOU !