NATURAL KILLER CELLS WAYNE BORCHERDING MT(ASCP). NATURAL KILLER CELLS u DEVELOPMENT u RECEPTORS u FUNCTION u LABORATORY ANALYSIS.

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Presentation transcript:

NATURAL KILLER CELLS WAYNE BORCHERDING MT(ASCP)

NATURAL KILLER CELLS u DEVELOPMENT u RECEPTORS u FUNCTION u LABORATORY ANALYSIS

NATURAL KILLER CELLS u DEVELOPMENT u SITE

NATURAL KILLER CELLS u DEVELOPMETAL STAGES u COMMITMENT u MATURATION u MIGRATION

NATURAL KILLER CELLS u DEVELOPMENTAL STAGES

NATURAL KILLER CELLS u DEVELOPMENTAL STAGES

NATURAL KILLER CELLS u RECEPTORS u CD56 – CD16 u NK u CYTOKINE u CHEMOKINE u ADHESION

NATURAL KILLER CELLS u RECEPTORS u NK u KIR – HLA-A-B-C u CD94-NKG2 – HLA-G-E u NCR (NKp46,p44,p30) u LIR (ILT-2) u KLR

NATURAL KILLER CELLS u CYTOKINE u IL-2 u IL-15 u IL-1 u IL-10 u IL-12 u IL-18 u CHEMOKINE u CCR7 u CXCR1,2,3 u CX 3 CR1

NATURAL KILLER CELLS u BIOLOGICAL FUNCTION u CANCER u INFECTION u PREGNANCY u TRANSPLANTATION

NATURAL KILLER CELLS u PREGNANCY u MUCOSA AND ARTERIAL FUNCTION u PLACENTAL TROPHOBLAST INVASION

NATURAL KILLER CELLS u TRANSPLANTATION

NATURAL KILLER CELLS u LABORATORY ANALYSIS u CHARACTERIZATION u MORPHOLOGIC u FLOW CYTOMETRY

NATURAL KILLER CELLS u LABORATORY ANALYSIS u FUNCTIONAL ASSAYS u NON-MHC RESTRICTED KILLING u ADCC u LAK

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