- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres in aging Universal STELA – a method to measure telomeres Why do we age so differently? Laila Bendix, MD VELUX FONDEN Funded by:
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres - structure
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres - function Differentiating from DSB Shorten with cell aging Harley et al 1990, Nature End replication problem
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres relate to human aging Kimura et al 2008 Halaschek-Wiener et al 2008
- D A N I S H A G I N G R E S E A R C H C E N T E R - Do telomeres also shorten abruptly Do telomeres also shorten abruptly Signal free ends Graakjaer et al, Aging Cell kb 8 kb 4 kb 1.6 kb 0.6 kb 0.1 kb Very short telomeres Baird et al, Nat Genet 2003
- D A N I S H A G I N G R E S E A R C H C E N T E R - Abrupt shortening - mechanisms Passos et al 2007, NAR Ferenac et al, 2005; J Gerontol A Biol Sci Med Sci
- D A N I S H A G I N G R E S E A R C H C E N T E R - Overskrift Tekst Punkt 1 Punkt 2 Underpunkt 1
- D A N I S H A G I N G R E S E A R C H C E N T E R - Universal STELA – assay principles Universal STELA – assay principles
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres – Project part I Short telomeres in organismal aging Does the number of short telomeres predict mortality even better? Number of short telomeres and DNA repair DNA repair functional studies Mitochondrial function Snp´s
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres and social class What do we think telomere length is an age-related parameter that remains aberrant after many years, and therefore is a suitable marker for social stress during life. What do we know Individuals of lower socio-economic status have shorter telomeres than their peers of a higher socio-economic status. Cherkas et al, 2006 No association between socio-economic status and telomere length. Adams et al, 2007 What do we have CAMB, MONICA and DARC Newer and better (?) methods
- D A N I S H A G I N G R E S E A R C H C E N T E R - Telomeres – Project part II Establish a high throughput method to measure telomeres Measure telomere lengths on samples collected in the CAMB study … and later Examine other aging related molecular biomarkers on same samples Short telomeres and social class