Flucoral® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a broad spectrum Systemic Antifungal

Flucoral® Mechanism of action Inhibition of cytochrome P-450→Impairment of Ergosterol synthesis in the fungal cell membrane→Interfers with fungal cell membrane function &growth→stop the fungal growth N.B: Fluconazole is highly selective inhibitor to fungal cytochrome P-450 and doesn't affect on liver cytochrome P-450

Flucoral® Pharmacokinetics The bioavailability of orally administered Fluconazole is over 90% Absorption of fluconazole is unaffected by food or gastric acidity

Flucoral® Pharmacokinetics Peak plasma concentrations (C-max) occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours after oral administration

Flucoral® Pharmacokinetics Fluconazole lipophillicity will achieve tissue levels exceeding the required MICs for all pathognomonic fungi for a complete week.

Flucoral Effective Against Candida Species Infection At Wide Range Of Body Sites And Tissues.

Flucoral

Flucoral

Flucoral® Pharmacokinetics Fluconazole(FLUCORAL) is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.

Excellent Eradication Flucoral® Excellent Eradication Flucoral is well established as a first line management option for the treatment of localized and systemic C.albicans infections. Micheal V. Martin;Journal of Antimicrobial Chemotherapy (1999) 44.429-437

Pityriasis Versicolor

Flucoral® % cure & improvement rates Excellent eradication rates in PityriasisVersicolor Single dose fluconazole Vs Itraconazole % cure & improvement rates

Onychomycosis

%cure &improvement rates Flucoral® Excellent eradication rates in Onychomycosis %cure &improvement rates

Flucoral®

Flucoral®

Flucoral® Flucoral penetrates the nails and persists after twice weekly doses for 6 months in toenails and fingernails Amalia del Palacio et al ,dermatophytosis treatment (2000).Madrid,Spain

Indications: 1: tinea Capitis. 2: Tinea cruris

Tinea Barbe. Tinea Corporis.

Tinea Pedis. Tinea Versicolor.

Onychomycosis. Candidiasis.

Flucoral® Safety Fluconazole is contraindicated in lactating women and category C in pregnant women.

American Family Physician,February 15,2001;Volume 63,Number 4 Flucoral® Monitoring of liver enzymes is not recommended during therapy with fluconazole (FLUCORAL) American Family Physician,February 15,2001;Volume 63,Number 4

Journal of antimicrobial chemotherapy.1999 Flucoral® Itraconazole is not suitable for the routine treatment of infections in patients with raised liver enzymes,history of liver diseases when treatment prolonged (>1 month) liver enzyme monitoring should be undertaken Journal of antimicrobial chemotherapy.1999

Flucoral® Flucoral is available as a box containing 2 capsules each containing Fluconazole 150mg with a price of 14.60 LE.

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