Spontaneous Damage to DNA. Examples of DNA Damage Induced by Radiation and Chemicals.

Slides:



Advertisements
Similar presentations
About XP Xeroderma pigmentosum was first described in 1874 by Hebra and Kaposi. In 1882, Kaposi coined the term xeroderma pigmentosum for the condition,
Advertisements

If you haven’t done so already, REGISTER TO VOTE! You live in a free country; make your voice heard! This website will take you through the process to.
DNA Repair Nucleotide Excision Repair XP and CS BiS222 By Jooyoung Chang 장주영 Class #01 / Stu. #
DNA repair. spontaneous vs. induced mutation gametic vs. somatic mutation lethal or conditional mutation Classification of the mutation.
Jordan A. Mays. Key Points: 8 XP family proteins repair DNA damaged by sunlight through Nucleotide Excision Repair. XPF-ERCC1 complex is a structure-specific.
DNA damage & repair.
Xeroderma Pigmentosum(XP) 着色性干皮病. We owe our lives to light from the sun,which provides the energy captured during photosynthesis ( 光合作用 ). But the sun.
Gene Mutation. Mutation Mutation: change in DNA sequence Causes of mutation: Spontaneous Due to naturally- occurring errors in DNA replication Induced.
DNA damage and repair Types of damage Direct reversal of damage Excision repair in prokaryotes and eukaryotes base excision nucleotide excision Nonhomologous.
Genetic Material-DNA 6 November 2003 Reading:The Cell; Chapter 5, pages:
XERODERMA PIGMENTOSUM XPF and Nucleotide Excision Repair Sapna Patel
Xeroderma Pigmentosum, XPF and Nucleotide Excision Repair By Crystal Stanford.
Gene Mutation *Mutation Chromosome mutations/aberrations Classification of Mutations 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation 2.
22 September, 2006 Chapter 9 Mutation and Repair.
DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS.
The Mutability and Repair of DNA
Chapter 20 DNA Replication and Repair. Replication is bidirectional.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Translation  mRNA is translated in codons (three nucleotides)  Translation.
Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis.
1 Mutations Mutations are inheritable changes in the DNA –“Failure to faithfully store genetic information” Changes can be to chromosomes or genes –Current.
Mutations Chapter Twelve. What is a Mutation? Change in DNA’s nucleotide sequence 1.Specific base changes –Molecular level 2.Chromosomal rearrangement.
Control of skin cancer by the circadian rhythm Background presented by Nathalie Javidi-Sharifi Druker Lab.
The Mutability and Repair of DNA
Cancer Cell cycle, oncogenes and tumour suppressors Jake Turner.
Gene Mutations.
GROUP 4.
Mutations in Replication What did you learn in your reading? Who performs mismatch repair? Why does DNA constantly have to be maintained? What.
DNA Repair Uracil-DNA Glycosylase. DNA is continually assaulted by damaging agents (oxygen free radicals, ultraviolet light, toxic chemicals). Fortunately,
William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 15 Gene Mutation, DNA Repair, and Transposition Copyright.
Maintenance of genomes Correcting replication errors Repairing DNA damage.
Michael Cummings David Reisman University of South Carolina Mutation: The Source of Genetic Variation Chapter 11.
Mutations. Learning Objectives By the end of this class you should understand: The pedigree of a spontaneous mutation The concept of mutation rates and.
Mutations. Sickle Cell Anemia Mutations Can be a change in the DNA base sequence or a change in a chromosome Can be a change in the DNA base sequence.
DNA REPAIR.
8.5 DNA Repair At the end of S phase, DNA polymerase has copied both strands of template DNA DNA polymerase does make mistakes -1 mistake every 10,000.
DNA Repair Lehninger, chapters 8 and 25 Blackburn & Gait, Ch. 6 and 8
Copyright © 2009 Pearson Education, Inc. Chapter 15 Lecture Concepts of Genetics Tenth Edition Gene Mutation, DNA Repair, and Transposition.
Various ways in which DNA damage leads to mutations in proteins Insertion.
Gene and Chromosomal Mutations. What is a mutation? Mutations are changes made to an organism’s genetic material. These changes may be due to errors in.
Dr. Asad Vaisi-Rayggani Department of Clinical Biochemistry Kermanshah University of Medical Sciences DNA Repair and.
Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 16.
12.6 DNA Repair. DNA Repair Errors in DNA replication or damage to DNA create mutations Errors in DNA replication or damage to DNA create mutations -
DNA Mutations and Repair Chapter 17. Mutation: is defined as an inherited change in genetic information by cell division or individual organisms. Chernobyl,
GENETICS ESSENTIALS Concepts and Connections SECOND EDITION GENETICS ESSENTIALS Concepts and Connections SECOND EDITION Benjamin A. Pierce © 2013 W. H.
DNA Repair DNA repair is a system used to correct DNA damage caused by either: 1-Errors during DNA replication including incorrect base-pairing (mismatching)
DNA Repair DNA repair is a system used to correct DNA damage caused by either: A- Errors during DNA replication including incorrect base-pairing (mismatching.
Today’s Agenda: 1. A Microarray Primer 2. Guest Speaker: Dr. Michael Schlador 3. Follow-up: the Use of Microarray Analysis in Chemotherapeutics 4. Preview.
Depurination Release of adenine or guanine bases.
Regulation of Bacterial Gene Expression Constitutive enzymes are expressed at a fixed rate. Other enzymes are expressed only as needed. –Repressible enzymes.
11.1DNA Is Reproduced by Semiconservative Replication.
Xeroderma Pigmentosum (XPF) Cara Mitchell. Characteristics of XP  Extreme photosensitivity  Early onset of skin cancers  Blistering of skin from sun.
Dr.Aida Fadhel Biawi 2014 Mechanisms of DNA repair.
Aim :How are the mistakes that occur during DNA replication repaired?
Lecture 3.Mutations and DNA Reparation Myandina Galina Ivanovna professor, Ph.D.,Dr.Sc.
Lecture 18 DNA Repair Rohini. K. Learning Objective 08 Nov 2011Rohini K FoM 2  An overview of the types of DNA damage  DNA repair mechanisms  Defects.
DNA Replication, Repair & Recombination
Xeroderma Pigmentosum, XPF
DNA Replication, Repair & Recombination
DNA Mutations and Repair
DNA Mutations and Repair
DNA Mutations and Repair
DNA Mutations and Repair
DNA Mutations and Repair
M.B.Ch.B, MSC, DCH (UK), MRCPCH
Lesson 3 Thursday, 11/14 AIM: What is a telomere?
 MISMATCH REPAIR: corrects mistakes when DNA is copied
Mutations And Genetic Disorders
Mutations + Recombination = Genetic Variation!!
DNA Repair and Chromosome Structure
Chapter 9 Mutation and Repair 24 September, 2004.
Presentation transcript:

Spontaneous Damage to DNA

Examples of DNA Damage Induced by Radiation and Chemicals

Direct Repair of Thymine Dimers Not in humans

A metiltransferase é gasta nesta reacção

Base-Excision Repair

Nucleotide-Excision Repair of Thymine Dimers

Xeroderma pigmentosum Autosomal recessive mutations in several complementation groups Extreme sensitivity to sunlight Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population)

Nucleotide excision repair - Energéticamente ineficiente

Mismatch Repair in E. coli

Teste de Ames para agentes mutagenicos

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com Inc. All rights reserved.