Cell injury p.1 SYLLABUS:

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Presentation transcript:

Cell injury p.1 SYLLABUS: Robbins and Cotran, Pathologic Basis of Disease, Chapter: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death excluding: hypertrophy hyperplasia metaplasia necrosis apoptosis cellular aging

Cell injury p.1 15 Lipofuscin storage in myocardial cells 7929/09 Lipomatous (adipose) atrophy of the pancreas 17 Liver steatosis 22 Hyaline degeneration of the fibrous tissue 20 Calcification 3520/10 Gout (gouty tophus)

Lipofuscin storage in myocardial cells cardiomyocytes containing yellowish-brown intracytoplasmatic granules in a perinuclear location (candle flame shape)

Lipofuscin storage in myocardial cells (hematoxylin only)

Lipofuscin storage in myocardial cells

Lipomatous atrophy of the pancreas replacement of the pancreatic acini by adipose tissue large areas of total adipose atrophy isolating islands of Langerhans dilated pancreatic ducts and periductal fibrosis

Lipomatous atrophy of the pancreas

Lipomatous atrophy of the pancreas

Lipomatous atrophy of the pancreas

(frozen tissue sample, Sudan III): Liver steatosis (paraffin block, H&E): -clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing) (frozen tissue sample, Sudan III): -vacuoles with orange-stained substance (fat) (.ppt demonstration only, no slides during the microscopy lab)

Liver steatosis

Liver steatosis

Liver steatosis (paraffin block, H&E): -clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing) (frozen tissue sample, Sudan III): -vacuoles with orange-stained substance (fat)

Liver steatosis (Sudan III)

Liver steatosis (Sudan III)

Hyaline degeneration of the fibrous tissue thick, eosinophilic collagen fibers - few fibroblasts

Hyaline degeneration of the fibrous tissue

Hyaline degeneration of the fibrous tissue

Calcification basophilic calcium deposits within the artery wall

Calcification

Calcification (empty areas within the calcium deposits are artifacts)

Gout (gouty tophus) - clusters of pale-staining monosodium urate crystals surrounded by macrophages, lymphocytes and large foreign body giant cells

Gout (gouty tophus)

Gout (gouty tophus)

Gout (gouty tophus)