Slacker’s Guide to Neurotransmitters Prepared by Mike Ori.

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Presentation transcript:

Slacker’s Guide to Neurotransmitters Prepared by Mike Ori

Disclaimer Slackers please continue but note… – The summary was taken from our class notes and PowerPoint slides. They reflect my understanding and could be wrong. – The faculty has in no way vetted this document. – I’m really uncertain of anything with (?) or in red. – If you see something wrong, let me know. If you’re a gunner, shame on you for looking at this. Do your own work.

Key Decrease A lot Increase A lot A lot is relative. I used it when there were (++) indicators in the text.

PNS CNS ParasympatheticSympathetic ACh Memory Muscarinic Ganglion Skeletal NMJ Effector PTSDAutism Dementia Sleep Myasthenia Gravis* Slow Wave Sleep Awake DeliriumAlzheimer REM Sleep CholineAcetate Choline Acetyltransferase Cholinergic Basal Nucleus ARAS Basal N. Cord/interneurons *Net effect is as if there is a decrease in Ach

PNS CNS ParasympatheticSympathetic Dopamine Well Being Skeletal Movement Parkinson Huntington Tyrosine Hydroxylase (Limiting) Dopaminergic Ventral tegmental Area Substantia Nigra Catecholamine SNCVTA None detailed in class but peripheral effects of PD treatment cause GI upset. Schizophrenia Addiction L-DOPA DOPA Decarboxylase (Carbidopa inhibits) ADHD?

PNS CNS ParasympatheticSympathetic Serotonin Well Being Skeletal Tryptophan Hydroxylase (Limiting) Serotonergic AKA: 5-HT Raphe nuclei Raphe Descending pain modulation by GABA disinhibition of PAG OCD Anxiety Depression Tourette Eating Disorders

PNS CNS ParasympatheticSympathetic Norepinephrine Skeletal Adrenergic Locus Ceruleus Catecholamine LC Descending pain modulation by GABA disinhibition of PAG Memory Depression PTSD Ganglion Effector None described in class Tyrosine Hydroxylase (Limiting) … … Well Being Anxiety Sleep Awake Slow wave sleep REM Sleep ADHD

PNS CNS ParasympatheticSympathetic GABA Skeletal Gabaergic Increase GABA to slow brain activity If its inibited, think GABA Descending pain modulation by GABA disinhibition of PAG. Most likely neurotransmitter in any inhibitory synapse Seizure Glutamate Glutamic acid decarboxylase (Limiting) Well Being Anxiety Thalamic Reticular Cortical Regulation inattentive