Neurotransmissions in the Central Nervous System Prof. Alhaider.

Slides:

Advertisements

Similar presentations

What about communication between neurons?.  presynaptic ending – ◦ portion of the axon conveying information to the next neuron.

Advertisements

Neurotransmitters Chemicals that influence the firing of nerve cells Can “excite”-make firing more likely Or “inhibit” make firing less likely.

Neurotransmission and the CNS BY PROF. Azza El-Medany.

Neurotransmitters in the Central Nervous System By Prof. A. Alhaider Dept. of Pharmacology.

“Give One, Get One.” 1. Neurotransmitters 2. Endorphins 3. Hormones.

The Biology of Behavior

Biological Psychology

Receptors What!! There’s More??. Receptors are a very important part of Neurotransmission What we know….(or think we know) –The number of receptors and.

Psychopharmacology.  Complex  1.4 kg in weight  Pre frontal cortex  2% of body weight  20% of oxygen  15% of our cardiac input  10% of all energy.

Homework in – crossword sheet and Q’s on back

General Psychology (PY110)

  Everything psychological is simultaneously _________  Every idea, mood, urge is a biological happening  Love, laugh, and cry with your body  Many.

Neurotransmitters: Catecholamines & Acetylcholine Chapters 5 & 6

Neurotransmitters: Catecholamines & Acetylcholine Chapters 5 & 6 Catecholamines  Dopamine  Norepinephrine  Epinephrine Acetylcholine Serotonin Glutamate.

Drugs and the Nervous System Chapter 3.  The nervous system is an electro-chemical communication system that regulates all physiological systems  Psychotropic.

Amines & Amides Dr. Michael P. Gillespie. Introduction Amines and Amides contain nitrogen. Nitrogen is an important component in the structure of the.

Acetylcholine Muscle action Learning/Memory Decreased levels associated with Alzheimer disease.

Psychopharmacology Inmaculada Ibanez-Casas, PhD

 chemicals released by vesicles in sending neuron  travel across the synapse and bind to receptor sites on receiving neuron 2 TYPES = EXCITATORY = stimulate.

 Neurons don’t actually touch  Separated by a tiny fluid-filled gap called a synapse  Neural impulses must be ferried across the synapse by chemical.

Neurotransmitters and the Endocrine System Chemical Messengers.

 A synapse divides at least 2 (usually more) neurons by ~20nm.  Presynaptic Neurons: carry impulses to the synapse  Postsynaptic Neurons: carry impulses.

Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.

Neurons, Neurotransmitters, and Systems. Structure of a Neuron.

Integrative Approach to Abnormal Behavior Chapter 2.

Neurotransmitters!. What is a neuron? Basic cells in the brain.

The Biological Bases of Behavior: The Neuron What is the nervous system?

Surveying the Chapter: Overview What We Have in Mind  Building blocks of the mind: neurons and how they communicate (neurotransmitters)  Systems that.

Neurotransmitters Information in this presentation taken from UCCP Content.

Neurotransmitters Are Your Friends

Communication between neurons is the foundation for brain function

Chapter 3 pt. A: Biology, Neurons, and Brain Imagery.

Neurotransmissions in the Central Nervous System.

Your Brain: Use it or Lose it – Day 2 Created by: Deb Byrne.

Neurotransmitters. Acetylcholine (ACh) Enables muscle action, REM sleep, and memory Undersupply, as ACh- producing neurons deteriorate, marks Alzheimer’s.

How a Brain Cell Looks and Operates. Diagraming the Brain.

1 Psychology 304: Brain and Behaviour Lecture 15.

Psychology 304: Brain and Behaviour Lecture 15

Pharmacology of central Neurotransmitters Prof. Yieldez.

Neurotransmissions in the Central Nervous System Prof. Alhaider.

NEUROTRANSMITTERS THE MESSENGERS OF NERVE CELLS.

So You Think You Know the Neurotransmitters? a Courtney Evans production GO!

Neurotransmitters.

Starting small: The Neuron

Neurobiological Theories of Mental Disorders

Anatomy of a Neuron Information is carried by biochemical substances called neurotransmitters. The terminal buttons and the dendrites of other neurons.

What is a neurotransmitter?

Pharmacology of central Neurotransmitters Prof. Yieldez Bassiouni

Neurotransmitters Lec 7.

Neurotransmitters Please pick up a chart from the AP Psych tray & get out your neuron diagram from yesterday 

Neurotransmitters.

Biological Psychology

Aim: How Does the Body Communicate Internally?

Neurons and Neurotransmission

What makes us feel, act, and think?

The Nervous System Your body’s communication network & control center

What are the current guidelines for healthy living

How does a Neuron fire? Resting potential

Neurons and Neurotransmission

Chapter 2 Biopsychology.

Problems with Imbalance Substances that Affect

Chapter 2: Biology, Neurons, and Brain Imagery

Pharmacology of central neurotransmitter

Neurotransmitters and the Synapse

Types of Neurotransmitters & Their Effects on the N.S.

The Nervous System Your body’s communication network & control center

BRAIN BIOLOGY Or “What’s inside my head?”

Presentation transcript:

Neurotransmissions in the Central Nervous System Prof. Alhaider

 What is the importance of understanding the type of neurotransmitter in the CNS? - To understand the etiology of diseases. - To suggest the best drug (s) to be used. - To understand the other clinical uses of any particular drug.

Norepinephrine ( NE)

Mode Disorders and Neurotransmissions Mode Disorders and Neurotransmissions Affective Disorders NE NE Mania Depression Mania Depression Rx Drugs that decrease NE Drugs that increase NE What is the evidence to support this theory?. What is the evidence to support this theory?.

 Answer: –Antidepressant drugs act by increasing NE or 5-HT or both while mania could be managed by drugs that decrease central NE –Drugs that deplete or decrease NE or 5-HT (reserpine; Clonidine; Mehtyldopa) lead to depression while drugs that increase NE like amphetamine may give rise to manai

Serotonin ( 5HT)  Although the CNS contains less than 2% of the total serotonin in the body, serotonin plays a very important role in a range of brain functions including :  Mood control  Regulation of sleep  Pain perception

 Diseases that are influenced by derangement of 5-HT: –Affective Disorders –Schizophrenia –Obsessive Compulsive Disorders –Generalized Anxiety –Nausea and Vomiting (Rx by 5-HT3 antagonists)

Dopamine

What are the diseases that influenced by dopamine? Schizophrenia Parkinson Disease Nausea and Vomiting Infertility

Acetylcholine:  Is Acetylcholine an inhibitory or excitatory neurotransmitter?  Does acetylcholine has any role in the CNS?  What are the CNS diseases that linked to ACH derangement?

Role of Acetylcholine in the CNS ACH is thought to be involved in cognitive functions such as : ACH is thought to be involved in cognitive functions such as : memory memory arousal arousal attention. attention.

What are the CNS diseases that linked to ACH derangement ?  Damage to cholinergic receptors (muscarinic) is associated with memory deficits as in Alzheimer, s disease  Increase brain level of ACH predispose to Parkinson, s disease

Glutamic acid Glutamic acid  Glutamic acid is an excitatory neurotransmitter is an excitatory neurotransmitter Increase in its level predispose Increase in its level predispose to epilepsy to epilepsy

GABA  GABA is an inhibitory neurotransmitter is an inhibitory neurotransmitter Decrease in GABA level is Decrease in GABA level is associated with epilepsy. associated with epilepsy.

 Conclusion: –With out understanding the involvement of neurotrasmittors in the etiology of CNS diseases, Doctors could not select the proper drug (s) for any particular disease.