PHC 222 Part(I) Dr. Huda Al Salem Lecture (4). Factors that affect the affinity 3- Stereochemistry of the drug.

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Presentation transcript:

PHC 222 Part(I) Dr. Huda Al Salem Lecture (4)

Factors that affect the affinity 3- Stereochemistry of the drug

Example 1: Acetylcholine

3- Stereochemistry of the drug Conformation is the spatial arrangement of atoms in a molecule that comes from free rotation of atoms around a single chemical bond. Requirement: It occurs without breaking bonds.. Configuration is the spatial arrangement of bonds in a molecule in a permanent geometry. Requirement: can be changed only by breaking bonds

3- Stereochemistry of the drug A B C  C`  A`  C`  A`  B`

Example 2: Norephedrine

Example 3: Labetalol

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